Breath-hold MR measurements of fat fraction, T1, and T2 of water and fat in vertebral bone marrow
Purpose To assess the feasibility of measuring the fat fraction, T1 and T2* relaxation times of water and fat signals in vertebral bone marrow using breath‐hold magnetic resonance imaging (MRI) gradient echo images of the spine. Materials and Methods MRI experiments were performed at 1.5T on eight h...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2016-09, Vol.44 (3), p.549-555 |
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| creator | Le Ster, Caroline Gambarota, Giulio Lasbleiz, Jérémy Guillin, Raphaël Decaux, Olivier Saint-Jalmes, Hervé |
| description | Purpose
To assess the feasibility of measuring the fat fraction, T1 and T2* relaxation times of water and fat signals in vertebral bone marrow using breath‐hold magnetic resonance imaging (MRI) gradient echo images of the spine.
Materials and Methods
MRI experiments were performed at 1.5T on eight healthy volunteers (35.1 ± 15.7 years, five men and three women) using two sagittal four‐echo 3D gradient echo volumetric interpolated breath‐hold examination (VIBE Dixon) sequences acquired at two different flip angles (5° and 15°). The water/fat decomposition was performed in the vertebral bodies of L1 to L5 by fitting the signal to a function that depends on the echo time and the flip angle to calculate the fat fraction (FF) and T1 and T2* relaxation times of water and fat signals. Repeatability was assessed by scanning one volunteer six times.
Results
The mean fat fraction over L1 to L5 was 33 ± 8%. The mean T1 and T2* of water and fat signals were respectively T1w = 701 ± 151 msec, T2*w = 13.7 ± 2.9 msec, T1f = 334 ± 113 msec, and T2*f = 11.4 ± 2.7 msec. When considering each vertebra separately, the fat fraction increased from L1 to L5 and the T1w decreased from L1 to L5. The mean coefficients of variation obtained from the repeatability study were 8% (FF), 11% (T1w), 17% (T1f), 8% (T2*w), and 27% (T2*f).
Conclusion
The method introduced in the current study allows for the measurement of the fat fraction and water and fat relaxation times, with a total acquisition time of less than 40 seconds. J. Magn. Reson. Imaging 2016;44:549–555. |
| doi_str_mv | 10.1002/jmri.25205 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01286302v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1811297073</sourcerecordid><originalsourceid>FETCH-LOGICAL-h3045-d9326ef64bd284a95226bd64de00ac013494ca5b834bc994a812fd4c3e6dd6923</originalsourceid><addsrcrecordid>eNpdkUtv1DAUhS0Eoi82_ABkiQ2VmnL9jLMsFXSKpvShQUVsLCd2NBmSuNhJh_57nJkyC1a-9v3OvTo-CL0lcEoA6MdVF5pTKiiIF2ifCEozKpR8mWoQLCMK8j10EOMKAIqCi9doj8qCKKpgH5lPwZlhmS19a_HVHe6ciWNwneuHiH2NazPgOphqaHx_ghfkBJve4gWdemszuLC5T1TT40cXBlcG0-LS9w53JgS_PkKvatNG9-b5PETfv3xenM-y-fXF5fnZPFsy4CKzBaPS1ZKXlipuimRDllZy6wBMBYTxgldGlIrxsko2jCK0trxiTlorC8oO0fF27tK0-iE0afuT9qbRs7O5nt6AUCUZ0EeS2A9b9iH436OLg-6aWLm2Nb3zY9REEUKLHHKW0Pf_oSs_hj452VDAqZAyUe-eqbHsnN3t__fRCSBbYN207mnXJ6CnCPUUod5EqL9e3V1uqqTJtpomDu7PTmPCLy1zlgt9_-1CL27y2c_b-5n-wf4Ce5uaOQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1811042566</pqid></control><display><type>article</type><title>Breath-hold MR measurements of fat fraction, T1, and T2 of water and fat in vertebral bone marrow</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Le Ster, Caroline ; Gambarota, Giulio ; Lasbleiz, Jérémy ; Guillin, Raphaël ; Decaux, Olivier ; Saint-Jalmes, Hervé</creator><creatorcontrib>Le Ster, Caroline ; Gambarota, Giulio ; Lasbleiz, Jérémy ; Guillin, Raphaël ; Decaux, Olivier ; Saint-Jalmes, Hervé</creatorcontrib><description>Purpose
To assess the feasibility of measuring the fat fraction, T1 and T2* relaxation times of water and fat signals in vertebral bone marrow using breath‐hold magnetic resonance imaging (MRI) gradient echo images of the spine.
Materials and Methods
MRI experiments were performed at 1.5T on eight healthy volunteers (35.1 ± 15.7 years, five men and three women) using two sagittal four‐echo 3D gradient echo volumetric interpolated breath‐hold examination (VIBE Dixon) sequences acquired at two different flip angles (5° and 15°). The water/fat decomposition was performed in the vertebral bodies of L1 to L5 by fitting the signal to a function that depends on the echo time and the flip angle to calculate the fat fraction (FF) and T1 and T2* relaxation times of water and fat signals. Repeatability was assessed by scanning one volunteer six times.
Results
The mean fat fraction over L1 to L5 was 33 ± 8%. The mean T1 and T2* of water and fat signals were respectively T1w = 701 ± 151 msec, T2*w = 13.7 ± 2.9 msec, T1f = 334 ± 113 msec, and T2*f = 11.4 ± 2.7 msec. When considering each vertebra separately, the fat fraction increased from L1 to L5 and the T1w decreased from L1 to L5. The mean coefficients of variation obtained from the repeatability study were 8% (FF), 11% (T1w), 17% (T1f), 8% (T2*w), and 27% (T2*f).
Conclusion
The method introduced in the current study allows for the measurement of the fat fraction and water and fat relaxation times, with a total acquisition time of less than 40 seconds. J. Magn. Reson. Imaging 2016;44:549–555.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.25205</identifier><identifier>PMID: 26918280</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adipose Tissue - diagnostic imaging ; Adipose Tissue - physiology ; Adiposity - physiology ; Adult ; Bioengineering ; Body Water - diagnostic imaging ; Body Water - physiology ; Bone Marrow - diagnostic imaging ; Bone Marrow - physiology ; chemical shift imaging ; Engineering Sciences ; Feasibility Studies ; Female ; Humans ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Imaging ; Life Sciences ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - physiology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; relaxation times ; Reproducibility of Results ; Respiratory Mechanics ; Sensitivity and Specificity ; Signal and Image processing ; vertebral bone marrow ; vertebral fat fraction ; VIBE Dixon ; Young Adult</subject><ispartof>Journal of magnetic resonance imaging, 2016-09, Vol.44 (3), p.549-555</ispartof><rights>2016 International Society for Magnetic Resonance in Medicine</rights><rights>2016 International Society for Magnetic Resonance in Medicine.</rights><rights>2016 Wiley Periodicals, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.25205$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.25205$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26918280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-rennes.hal.science/hal-01286302$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Ster, Caroline</creatorcontrib><creatorcontrib>Gambarota, Giulio</creatorcontrib><creatorcontrib>Lasbleiz, Jérémy</creatorcontrib><creatorcontrib>Guillin, Raphaël</creatorcontrib><creatorcontrib>Decaux, Olivier</creatorcontrib><creatorcontrib>Saint-Jalmes, Hervé</creatorcontrib><title>Breath-hold MR measurements of fat fraction, T1, and T2 of water and fat in vertebral bone marrow</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To assess the feasibility of measuring the fat fraction, T1 and T2* relaxation times of water and fat signals in vertebral bone marrow using breath‐hold magnetic resonance imaging (MRI) gradient echo images of the spine.
Materials and Methods
MRI experiments were performed at 1.5T on eight healthy volunteers (35.1 ± 15.7 years, five men and three women) using two sagittal four‐echo 3D gradient echo volumetric interpolated breath‐hold examination (VIBE Dixon) sequences acquired at two different flip angles (5° and 15°). The water/fat decomposition was performed in the vertebral bodies of L1 to L5 by fitting the signal to a function that depends on the echo time and the flip angle to calculate the fat fraction (FF) and T1 and T2* relaxation times of water and fat signals. Repeatability was assessed by scanning one volunteer six times.
Results
The mean fat fraction over L1 to L5 was 33 ± 8%. The mean T1 and T2* of water and fat signals were respectively T1w = 701 ± 151 msec, T2*w = 13.7 ± 2.9 msec, T1f = 334 ± 113 msec, and T2*f = 11.4 ± 2.7 msec. When considering each vertebra separately, the fat fraction increased from L1 to L5 and the T1w decreased from L1 to L5. The mean coefficients of variation obtained from the repeatability study were 8% (FF), 11% (T1w), 17% (T1f), 8% (T2*w), and 27% (T2*f).
Conclusion
The method introduced in the current study allows for the measurement of the fat fraction and water and fat relaxation times, with a total acquisition time of less than 40 seconds. J. Magn. Reson. Imaging 2016;44:549–555.</description><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adipose Tissue - physiology</subject><subject>Adiposity - physiology</subject><subject>Adult</subject><subject>Bioengineering</subject><subject>Body Water - diagnostic imaging</subject><subject>Body Water - physiology</subject><subject>Bone Marrow - diagnostic imaging</subject><subject>Bone Marrow - physiology</subject><subject>chemical shift imaging</subject><subject>Engineering Sciences</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging</subject><subject>Life Sciences</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - physiology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>relaxation times</subject><subject>Reproducibility of Results</subject><subject>Respiratory Mechanics</subject><subject>Sensitivity and Specificity</subject><subject>Signal and Image processing</subject><subject>vertebral bone marrow</subject><subject>vertebral fat fraction</subject><subject>VIBE Dixon</subject><subject>Young Adult</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtv1DAUhS0Eoi82_ABkiQ2VmnL9jLMsFXSKpvShQUVsLCd2NBmSuNhJh_57nJkyC1a-9v3OvTo-CL0lcEoA6MdVF5pTKiiIF2ifCEozKpR8mWoQLCMK8j10EOMKAIqCi9doj8qCKKpgH5lPwZlhmS19a_HVHe6ciWNwneuHiH2NazPgOphqaHx_ghfkBJve4gWdemszuLC5T1TT40cXBlcG0-LS9w53JgS_PkKvatNG9-b5PETfv3xenM-y-fXF5fnZPFsy4CKzBaPS1ZKXlipuimRDllZy6wBMBYTxgldGlIrxsko2jCK0trxiTlorC8oO0fF27tK0-iE0afuT9qbRs7O5nt6AUCUZ0EeS2A9b9iH436OLg-6aWLm2Nb3zY9REEUKLHHKW0Pf_oSs_hj452VDAqZAyUe-eqbHsnN3t__fRCSBbYN207mnXJ6CnCPUUod5EqL9e3V1uqqTJtpomDu7PTmPCLy1zlgt9_-1CL27y2c_b-5n-wf4Ce5uaOQ</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Le Ster, Caroline</creator><creator>Gambarota, Giulio</creator><creator>Lasbleiz, Jérémy</creator><creator>Guillin, Raphaël</creator><creator>Decaux, Olivier</creator><creator>Saint-Jalmes, Hervé</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>201609</creationdate><title>Breath-hold MR measurements of fat fraction, T1, and T2 of water and fat in vertebral bone marrow</title><author>Le Ster, Caroline ; Gambarota, Giulio ; Lasbleiz, Jérémy ; Guillin, Raphaël ; Decaux, Olivier ; Saint-Jalmes, Hervé</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h3045-d9326ef64bd284a95226bd64de00ac013494ca5b834bc994a812fd4c3e6dd6923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adipose Tissue - physiology</topic><topic>Adiposity - physiology</topic><topic>Adult</topic><topic>Bioengineering</topic><topic>Body Water - diagnostic imaging</topic><topic>Body Water - physiology</topic><topic>Bone Marrow - diagnostic imaging</topic><topic>Bone Marrow - physiology</topic><topic>chemical shift imaging</topic><topic>Engineering Sciences</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Imaging</topic><topic>Life Sciences</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - physiology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>relaxation times</topic><topic>Reproducibility of Results</topic><topic>Respiratory Mechanics</topic><topic>Sensitivity and Specificity</topic><topic>Signal and Image processing</topic><topic>vertebral bone marrow</topic><topic>vertebral fat fraction</topic><topic>VIBE Dixon</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Ster, Caroline</creatorcontrib><creatorcontrib>Gambarota, Giulio</creatorcontrib><creatorcontrib>Lasbleiz, Jérémy</creatorcontrib><creatorcontrib>Guillin, Raphaël</creatorcontrib><creatorcontrib>Decaux, Olivier</creatorcontrib><creatorcontrib>Saint-Jalmes, Hervé</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Ster, Caroline</au><au>Gambarota, Giulio</au><au>Lasbleiz, Jérémy</au><au>Guillin, Raphaël</au><au>Decaux, Olivier</au><au>Saint-Jalmes, Hervé</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breath-hold MR measurements of fat fraction, T1, and T2 of water and fat in vertebral bone marrow</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2016-09</date><risdate>2016</risdate><volume>44</volume><issue>3</issue><spage>549</spage><epage>555</epage><pages>549-555</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To assess the feasibility of measuring the fat fraction, T1 and T2* relaxation times of water and fat signals in vertebral bone marrow using breath‐hold magnetic resonance imaging (MRI) gradient echo images of the spine.
Materials and Methods
MRI experiments were performed at 1.5T on eight healthy volunteers (35.1 ± 15.7 years, five men and three women) using two sagittal four‐echo 3D gradient echo volumetric interpolated breath‐hold examination (VIBE Dixon) sequences acquired at two different flip angles (5° and 15°). The water/fat decomposition was performed in the vertebral bodies of L1 to L5 by fitting the signal to a function that depends on the echo time and the flip angle to calculate the fat fraction (FF) and T1 and T2* relaxation times of water and fat signals. Repeatability was assessed by scanning one volunteer six times.
Results
The mean fat fraction over L1 to L5 was 33 ± 8%. The mean T1 and T2* of water and fat signals were respectively T1w = 701 ± 151 msec, T2*w = 13.7 ± 2.9 msec, T1f = 334 ± 113 msec, and T2*f = 11.4 ± 2.7 msec. When considering each vertebra separately, the fat fraction increased from L1 to L5 and the T1w decreased from L1 to L5. The mean coefficients of variation obtained from the repeatability study were 8% (FF), 11% (T1w), 17% (T1f), 8% (T2*w), and 27% (T2*f).
Conclusion
The method introduced in the current study allows for the measurement of the fat fraction and water and fat relaxation times, with a total acquisition time of less than 40 seconds. J. Magn. Reson. Imaging 2016;44:549–555.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26918280</pmid><doi>10.1002/jmri.25205</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue - diagnostic imaging Adipose Tissue - physiology Adiposity - physiology Adult Bioengineering Body Water - diagnostic imaging Body Water - physiology Bone Marrow - diagnostic imaging Bone Marrow - physiology chemical shift imaging Engineering Sciences Feasibility Studies Female Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Imaging Life Sciences Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - physiology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged relaxation times Reproducibility of Results Respiratory Mechanics Sensitivity and Specificity Signal and Image processing vertebral bone marrow vertebral fat fraction VIBE Dixon Young Adult |
| title | Breath-hold MR measurements of fat fraction, T1, and T2 of water and fat in vertebral bone marrow |
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