Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response

Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized. The pathogenesis of CHIKV was addressed in a prospective cohort study of 49 ho...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-05, Vol.184 (10), p.5914-5927
Hauptverfasser:	Hoarau, Jean-Jacques, Jaffar Bandjee, Marie-Christine, Krejbich Trotot, Pascale, Das, Trina, Li-Pat-Yuen, Ghislaine, Dassa, Bérengère, Denizot, Mélanie, Guichard, Elsa, Ribera, Anne, Henni, Tawfiq, Tallet, Frank, Moiton, Marie Pierre, Gauzère, Bernard Alex, Bruniquet, Sandrine, Jaffar Bandjee, Zaïnoul, Morbidelli, Philippe, Martigny, Gérard, Jolivet, Michel, Gay, Frederick, Grandadam, Marc, Tolou, Hugues, Vieillard, Vincent, Debré, Patrice, Autran, Brigitte, Gasque, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Aged Aged, 80 and over Alphavirus Infections - epidemiology Alphavirus Infections - immunology Alphavirus Infections - pathology Arthralgia - diagnosis Arthralgia - immunology Arthralgia - virology Arthritis, Infectious - immunology Arthritis, Infectious - pathology Arthritis, Infectious - virology Chikungunya virus - immunology Chikungunya virus - pathogenicity Chronic Disease Cohort Studies Female Humans Immunity, Active Inflammation - epidemiology Inflammation - immunology Inflammation - virology Life Sciences Male Middle Aged Prospective Studies Reunion - epidemiology Viral Load - immunology Viremia - diagnosis Viremia - immunology Viremia - pathology Young Adult
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