Impact of pre- and post-procedural anemia on the incidence of acute kidney injury and 1-year mortality in patients undergoing transcatheter aortic valve implantation (from the French Aortic National CoreValve and Edwards 2 [FRANCE 2] Registry)
Objectives The relationship between anemia, renal insufficiency, and the outcomes of TAVI patients has not been thoroughly studied. We aimed to evaluate the influence of pre‐ and post‐procedural anemia on the incidence of renal insufficiency, especially AKI, and on the outcomes of TAVI. Methods Data...
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| Veröffentlicht in: | Catheterization and cardiovascular interventions 2015-06, Vol.85 (7), p.1231-1239 |
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| creator | Arai, Takahide Morice, Marie-Claude O'Connor, Stephen A. Yamamoto, Masanori Eltchaninoff, Hélène Leguerrier, Alain Leprince, Pascal Laskar, Marc Iung, Bernard Fajadet, Jean Prat, Alain Lièvre, Michel Donzeau-Gouge, Patrick Chevreul, Karine Teiger, Emmanuel Lefèvre, Thierry Gilard, Martine |
| description | Objectives
The relationship between anemia, renal insufficiency, and the outcomes of TAVI patients has not been thoroughly studied. We aimed to evaluate the influence of pre‐ and post‐procedural anemia on the incidence of renal insufficiency, especially AKI, and on the outcomes of TAVI.
Methods
Data from the French national TAVI registry were collected in 3,472 patients who underwent TAVI between January 2010 and December 2012. Of these 2,137 were in the no/mild anemia group, 748 were in the moderate anemia group, and 587 were in the severe anemia group before TAVI. Furthermore, we divided the 3,472 patients into three groups according to post‐procedural anemia, measured as post‐procedural hemoglobin (Hb) drop: |
| doi_str_mv | 10.1002/ccd.25832 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01282355v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3691555821</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5612-265570b26f8a8fa17038cb90bf896b1c524ae3a052be38947649ba97832cb6b63</originalsourceid><addsrcrecordid>eNp1ktFu0zAYhSMEYqNwwQsgS9xsF9lsJ3aSyy6027SqSAMGEkKW4zittyQOttOR5-YFcJuuSEhcRIn8f-cc688JgrcIniEI8bkQ5RkmaYSfBceIYBwmmH57vv9GWUyPglfW3kMIM4qzl8ERJjRGCMHj4Pd103HhgK5AZ2QIeFuCTlsXdkYLWfaG1_5MNooD3QK3lkC1QpWyFXKr4aJ3EjyospWDn9z3ZthZoHCQ3IBGG8dr5bYz0HGnZOss6NtSmpVW7Qo4w1sruPd10gDucSXAhtcbn9N0NW-dF_ngk8roZhc_Nz57DaYjutyN_R1zbeTdTreNn5WP3JQWYPB9fjtd5jOAf4BbuVLWmeH0dfCi4rWVb_bvSfBlPvucX4WLj5fX-XQRCkIRDjElJIEFplXK04qjBEapKDJYVGlGCyQIjrmMOCS4kFGaxQmNs4Jnif8PoqAFjSbB6ei75jXrjGq4GZjmil1NF2x7BhFOcUTIBnn2ZGT93n_20jrWKCtk7VcgdW8ZoilOs4j4ZxK8_we9173xSxipKE58Ff6GC6OtNbI63ABBtm0N861hu9Z49t3esS8aWR7Ip5p44HwEHlUth_87sTz_8GQZjgq_cvnroODmgdEkSgj7urxkd_H85uIiuWGfoj8iCNw8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1682347583</pqid></control><display><type>article</type><title>Impact of pre- and post-procedural anemia on the incidence of acute kidney injury and 1-year mortality in patients undergoing transcatheter aortic valve implantation (from the French Aortic National CoreValve and Edwards 2 [FRANCE 2] Registry)</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Arai, Takahide ; Morice, Marie-Claude ; O'Connor, Stephen A. ; Yamamoto, Masanori ; Eltchaninoff, Hélène ; Leguerrier, Alain ; Leprince, Pascal ; Laskar, Marc ; Iung, Bernard ; Fajadet, Jean ; Prat, Alain ; Lièvre, Michel ; Donzeau-Gouge, Patrick ; Chevreul, Karine ; Teiger, Emmanuel ; Lefèvre, Thierry ; Gilard, Martine</creator><creatorcontrib>Arai, Takahide ; Morice, Marie-Claude ; O'Connor, Stephen A. ; Yamamoto, Masanori ; Eltchaninoff, Hélène ; Leguerrier, Alain ; Leprince, Pascal ; Laskar, Marc ; Iung, Bernard ; Fajadet, Jean ; Prat, Alain ; Lièvre, Michel ; Donzeau-Gouge, Patrick ; Chevreul, Karine ; Teiger, Emmanuel ; Lefèvre, Thierry ; Gilard, Martine ; FRANCE 2 Registry Investigators ; on behalf of FRANCE 2 Registry Investigators</creatorcontrib><description><![CDATA[Objectives
The relationship between anemia, renal insufficiency, and the outcomes of TAVI patients has not been thoroughly studied. We aimed to evaluate the influence of pre‐ and post‐procedural anemia on the incidence of renal insufficiency, especially AKI, and on the outcomes of TAVI.
Methods
Data from the French national TAVI registry were collected in 3,472 patients who underwent TAVI between January 2010 and December 2012. Of these 2,137 were in the no/mild anemia group, 748 were in the moderate anemia group, and 587 were in the severe anemia group before TAVI. Furthermore, we divided the 3,472 patients into three groups according to post‐procedural anemia, measured as post‐procedural hemoglobin (Hb) drop: <2 g/dl (n = 1,633, group 1), 2 to <4 g/dl (n = 1,458, group 2), and >4 g/dl (n = 381, group 3). Procedure and outcome variables were compared.
Results
Increased severity of anemia before TAVI was associated with significantly different rates of 1‐year mortality (15%, 19%, and 24%, P < 0.01), with similar differences in the incidence of AKI (5%, 8%, and 10%, P < 0.01). Increased severity of Hb drop was associated with significantly different rates of 1‐year mortality (16%, 18%, and 23%, P < 0.01), and with similar differences in the incidence of AKI (6%, 7%, and 10%, P = 0.04). Both pre‐ and post‐procedural anemia were predictors of the incidence of AKI (OR 1.82, P < 0.01; OR 1.82, P < 0.01, respectively) and 1‐year mortality (HR 1.44, P < 0.01; HR 1.50, P < 0.01, respectively).
Conclusions
Both pre‐ and post‐procedural anemia were significantly associated AKI and 1‐year mortality. © 2015 Wiley Periodicals, Inc.]]></description><identifier>ISSN: 1522-1946</identifier><identifier>EISSN: 1522-726X</identifier><identifier>DOI: 10.1002/ccd.25832</identifier><identifier>PMID: 25641110</identifier><identifier>CODEN: CARIF2</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>acute kidney injury ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - epidemiology ; Acute Kidney Injury - mortality ; Aged ; Aged, 80 and over ; anemia ; Anemia - blood ; Anemia - diagnosis ; Anemia - epidemiology ; Anemia - mortality ; Aortic Valve - physiopathology ; Aortic Valve Stenosis - diagnosis ; Aortic Valve Stenosis - mortality ; Aortic Valve Stenosis - physiopathology ; Aortic Valve Stenosis - therapy ; Biomarkers - blood ; Cardiac Catheterization - adverse effects ; Cardiac Catheterization - instrumentation ; Cardiac Catheterization - mortality ; Chi-Square Distribution ; Female ; France - epidemiology ; Heart Valve Prosthesis Implantation - adverse effects ; Heart Valve Prosthesis Implantation - instrumentation ; Heart Valve Prosthesis Implantation - mortality ; Hemoglobins - metabolism ; Humans ; Incidence ; Kaplan-Meier Estimate ; Life Sciences ; Logistic Models ; Male ; Multivariate Analysis ; Proportional Hazards Models ; Registries ; Risk Factors ; severe symptomatic aortic stenosis ; Severity of Illness Index ; Time Factors ; transcatheter aortic valve implantation ; Treatment Outcome</subject><ispartof>Catheterization and cardiovascular interventions, 2015-06, Vol.85 (7), p.1231-1239</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5612-265570b26f8a8fa17038cb90bf896b1c524ae3a052be38947649ba97832cb6b63</citedby><cites>FETCH-LOGICAL-c5612-265570b26f8a8fa17038cb90bf896b1c524ae3a052be38947649ba97832cb6b63</cites><orcidid>0000-0002-9127-348X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fccd.25832$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fccd.25832$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25641110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-rennes.hal.science/hal-01282355$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Arai, Takahide</creatorcontrib><creatorcontrib>Morice, Marie-Claude</creatorcontrib><creatorcontrib>O'Connor, Stephen A.</creatorcontrib><creatorcontrib>Yamamoto, Masanori</creatorcontrib><creatorcontrib>Eltchaninoff, Hélène</creatorcontrib><creatorcontrib>Leguerrier, Alain</creatorcontrib><creatorcontrib>Leprince, Pascal</creatorcontrib><creatorcontrib>Laskar, Marc</creatorcontrib><creatorcontrib>Iung, Bernard</creatorcontrib><creatorcontrib>Fajadet, Jean</creatorcontrib><creatorcontrib>Prat, Alain</creatorcontrib><creatorcontrib>Lièvre, Michel</creatorcontrib><creatorcontrib>Donzeau-Gouge, Patrick</creatorcontrib><creatorcontrib>Chevreul, Karine</creatorcontrib><creatorcontrib>Teiger, Emmanuel</creatorcontrib><creatorcontrib>Lefèvre, Thierry</creatorcontrib><creatorcontrib>Gilard, Martine</creatorcontrib><creatorcontrib>FRANCE 2 Registry Investigators</creatorcontrib><creatorcontrib>on behalf of FRANCE 2 Registry Investigators</creatorcontrib><title>Impact of pre- and post-procedural anemia on the incidence of acute kidney injury and 1-year mortality in patients undergoing transcatheter aortic valve implantation (from the French Aortic National CoreValve and Edwards 2 [FRANCE 2] Registry)</title><title>Catheterization and cardiovascular interventions</title><addtitle>Cathet. Cardiovasc. Intervent</addtitle><description><![CDATA[Objectives
The relationship between anemia, renal insufficiency, and the outcomes of TAVI patients has not been thoroughly studied. We aimed to evaluate the influence of pre‐ and post‐procedural anemia on the incidence of renal insufficiency, especially AKI, and on the outcomes of TAVI.
Methods
Data from the French national TAVI registry were collected in 3,472 patients who underwent TAVI between January 2010 and December 2012. Of these 2,137 were in the no/mild anemia group, 748 were in the moderate anemia group, and 587 were in the severe anemia group before TAVI. Furthermore, we divided the 3,472 patients into three groups according to post‐procedural anemia, measured as post‐procedural hemoglobin (Hb) drop: <2 g/dl (n = 1,633, group 1), 2 to <4 g/dl (n = 1,458, group 2), and >4 g/dl (n = 381, group 3). Procedure and outcome variables were compared.
Results
Increased severity of anemia before TAVI was associated with significantly different rates of 1‐year mortality (15%, 19%, and 24%, P < 0.01), with similar differences in the incidence of AKI (5%, 8%, and 10%, P < 0.01). Increased severity of Hb drop was associated with significantly different rates of 1‐year mortality (16%, 18%, and 23%, P < 0.01), and with similar differences in the incidence of AKI (6%, 7%, and 10%, P = 0.04). Both pre‐ and post‐procedural anemia were predictors of the incidence of AKI (OR 1.82, P < 0.01; OR 1.82, P < 0.01, respectively) and 1‐year mortality (HR 1.44, P < 0.01; HR 1.50, P < 0.01, respectively).
Conclusions
Both pre‐ and post‐procedural anemia were significantly associated AKI and 1‐year mortality. © 2015 Wiley Periodicals, Inc.]]></description><subject>acute kidney injury</subject><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - epidemiology</subject><subject>Acute Kidney Injury - mortality</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>anemia</subject><subject>Anemia - blood</subject><subject>Anemia - diagnosis</subject><subject>Anemia - epidemiology</subject><subject>Anemia - mortality</subject><subject>Aortic Valve - physiopathology</subject><subject>Aortic Valve Stenosis - diagnosis</subject><subject>Aortic Valve Stenosis - mortality</subject><subject>Aortic Valve Stenosis - physiopathology</subject><subject>Aortic Valve Stenosis - therapy</subject><subject>Biomarkers - blood</subject><subject>Cardiac Catheterization - adverse effects</subject><subject>Cardiac Catheterization - instrumentation</subject><subject>Cardiac Catheterization - mortality</subject><subject>Chi-Square Distribution</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Heart Valve Prosthesis Implantation - adverse effects</subject><subject>Heart Valve Prosthesis Implantation - instrumentation</subject><subject>Heart Valve Prosthesis Implantation - mortality</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Incidence</subject><subject>Kaplan-Meier Estimate</subject><subject>Life Sciences</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Proportional Hazards Models</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>severe symptomatic aortic stenosis</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>transcatheter aortic valve implantation</subject><subject>Treatment Outcome</subject><issn>1522-1946</issn><issn>1522-726X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ktFu0zAYhSMEYqNwwQsgS9xsF9lsJ3aSyy6027SqSAMGEkKW4zittyQOttOR5-YFcJuuSEhcRIn8f-cc688JgrcIniEI8bkQ5RkmaYSfBceIYBwmmH57vv9GWUyPglfW3kMIM4qzl8ERJjRGCMHj4Pd103HhgK5AZ2QIeFuCTlsXdkYLWfaG1_5MNooD3QK3lkC1QpWyFXKr4aJ3EjyospWDn9z3ZthZoHCQ3IBGG8dr5bYz0HGnZOss6NtSmpVW7Qo4w1sruPd10gDucSXAhtcbn9N0NW-dF_ngk8roZhc_Nz57DaYjutyN_R1zbeTdTreNn5WP3JQWYPB9fjtd5jOAf4BbuVLWmeH0dfCi4rWVb_bvSfBlPvucX4WLj5fX-XQRCkIRDjElJIEFplXK04qjBEapKDJYVGlGCyQIjrmMOCS4kFGaxQmNs4Jnif8PoqAFjSbB6ei75jXrjGq4GZjmil1NF2x7BhFOcUTIBnn2ZGT93n_20jrWKCtk7VcgdW8ZoilOs4j4ZxK8_we9173xSxipKE58Ff6GC6OtNbI63ABBtm0N861hu9Z49t3esS8aWR7Ip5p44HwEHlUth_87sTz_8GQZjgq_cvnroODmgdEkSgj7urxkd_H85uIiuWGfoj8iCNw8</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Arai, Takahide</creator><creator>Morice, Marie-Claude</creator><creator>O'Connor, Stephen A.</creator><creator>Yamamoto, Masanori</creator><creator>Eltchaninoff, Hélène</creator><creator>Leguerrier, Alain</creator><creator>Leprince, Pascal</creator><creator>Laskar, Marc</creator><creator>Iung, Bernard</creator><creator>Fajadet, Jean</creator><creator>Prat, Alain</creator><creator>Lièvre, Michel</creator><creator>Donzeau-Gouge, Patrick</creator><creator>Chevreul, Karine</creator><creator>Teiger, Emmanuel</creator><creator>Lefèvre, Thierry</creator><creator>Gilard, Martine</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-9127-348X</orcidid></search><sort><creationdate>201506</creationdate><title>Impact of pre- and post-procedural anemia on the incidence of acute kidney injury and 1-year mortality in patients undergoing transcatheter aortic valve implantation (from the French Aortic National CoreValve and Edwards 2 [FRANCE 2] Registry)</title><author>Arai, Takahide ; Morice, Marie-Claude ; O'Connor, Stephen A. ; Yamamoto, Masanori ; Eltchaninoff, Hélène ; Leguerrier, Alain ; Leprince, Pascal ; Laskar, Marc ; Iung, Bernard ; Fajadet, Jean ; Prat, Alain ; Lièvre, Michel ; Donzeau-Gouge, Patrick ; Chevreul, Karine ; Teiger, Emmanuel ; Lefèvre, Thierry ; Gilard, Martine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5612-265570b26f8a8fa17038cb90bf896b1c524ae3a052be38947649ba97832cb6b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>acute kidney injury</topic><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - epidemiology</topic><topic>Acute Kidney Injury - mortality</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>anemia</topic><topic>Anemia - blood</topic><topic>Anemia - diagnosis</topic><topic>Anemia - epidemiology</topic><topic>Anemia - mortality</topic><topic>Aortic Valve - physiopathology</topic><topic>Aortic Valve Stenosis - diagnosis</topic><topic>Aortic Valve Stenosis - mortality</topic><topic>Aortic Valve Stenosis - physiopathology</topic><topic>Aortic Valve Stenosis - therapy</topic><topic>Biomarkers - blood</topic><topic>Cardiac Catheterization - adverse effects</topic><topic>Cardiac Catheterization - instrumentation</topic><topic>Cardiac Catheterization - mortality</topic><topic>Chi-Square Distribution</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Heart Valve Prosthesis Implantation - adverse effects</topic><topic>Heart Valve Prosthesis Implantation - instrumentation</topic><topic>Heart Valve Prosthesis Implantation - mortality</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Incidence</topic><topic>Kaplan-Meier Estimate</topic><topic>Life Sciences</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Proportional Hazards Models</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>severe symptomatic aortic stenosis</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><topic>transcatheter aortic valve implantation</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arai, Takahide</creatorcontrib><creatorcontrib>Morice, Marie-Claude</creatorcontrib><creatorcontrib>O'Connor, Stephen A.</creatorcontrib><creatorcontrib>Yamamoto, Masanori</creatorcontrib><creatorcontrib>Eltchaninoff, Hélène</creatorcontrib><creatorcontrib>Leguerrier, Alain</creatorcontrib><creatorcontrib>Leprince, Pascal</creatorcontrib><creatorcontrib>Laskar, Marc</creatorcontrib><creatorcontrib>Iung, Bernard</creatorcontrib><creatorcontrib>Fajadet, Jean</creatorcontrib><creatorcontrib>Prat, Alain</creatorcontrib><creatorcontrib>Lièvre, Michel</creatorcontrib><creatorcontrib>Donzeau-Gouge, Patrick</creatorcontrib><creatorcontrib>Chevreul, Karine</creatorcontrib><creatorcontrib>Teiger, Emmanuel</creatorcontrib><creatorcontrib>Lefèvre, Thierry</creatorcontrib><creatorcontrib>Gilard, Martine</creatorcontrib><creatorcontrib>FRANCE 2 Registry Investigators</creatorcontrib><creatorcontrib>on behalf of FRANCE 2 Registry Investigators</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arai, Takahide</au><au>Morice, Marie-Claude</au><au>O'Connor, Stephen A.</au><au>Yamamoto, Masanori</au><au>Eltchaninoff, Hélène</au><au>Leguerrier, Alain</au><au>Leprince, Pascal</au><au>Laskar, Marc</au><au>Iung, Bernard</au><au>Fajadet, Jean</au><au>Prat, Alain</au><au>Lièvre, Michel</au><au>Donzeau-Gouge, Patrick</au><au>Chevreul, Karine</au><au>Teiger, Emmanuel</au><au>Lefèvre, Thierry</au><au>Gilard, Martine</au><aucorp>FRANCE 2 Registry Investigators</aucorp><aucorp>on behalf of FRANCE 2 Registry Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of pre- and post-procedural anemia on the incidence of acute kidney injury and 1-year mortality in patients undergoing transcatheter aortic valve implantation (from the French Aortic National CoreValve and Edwards 2 [FRANCE 2] Registry)</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Cathet. Cardiovasc. Intervent</addtitle><date>2015-06</date><risdate>2015</risdate><volume>85</volume><issue>7</issue><spage>1231</spage><epage>1239</epage><pages>1231-1239</pages><issn>1522-1946</issn><eissn>1522-726X</eissn><coden>CARIF2</coden><abstract><![CDATA[Objectives
The relationship between anemia, renal insufficiency, and the outcomes of TAVI patients has not been thoroughly studied. We aimed to evaluate the influence of pre‐ and post‐procedural anemia on the incidence of renal insufficiency, especially AKI, and on the outcomes of TAVI.
Methods
Data from the French national TAVI registry were collected in 3,472 patients who underwent TAVI between January 2010 and December 2012. Of these 2,137 were in the no/mild anemia group, 748 were in the moderate anemia group, and 587 were in the severe anemia group before TAVI. Furthermore, we divided the 3,472 patients into three groups according to post‐procedural anemia, measured as post‐procedural hemoglobin (Hb) drop: <2 g/dl (n = 1,633, group 1), 2 to <4 g/dl (n = 1,458, group 2), and >4 g/dl (n = 381, group 3). Procedure and outcome variables were compared.
Results
Increased severity of anemia before TAVI was associated with significantly different rates of 1‐year mortality (15%, 19%, and 24%, P < 0.01), with similar differences in the incidence of AKI (5%, 8%, and 10%, P < 0.01). Increased severity of Hb drop was associated with significantly different rates of 1‐year mortality (16%, 18%, and 23%, P < 0.01), and with similar differences in the incidence of AKI (6%, 7%, and 10%, P = 0.04). Both pre‐ and post‐procedural anemia were predictors of the incidence of AKI (OR 1.82, P < 0.01; OR 1.82, P < 0.01, respectively) and 1‐year mortality (HR 1.44, P < 0.01; HR 1.50, P < 0.01, respectively).
Conclusions
Both pre‐ and post‐procedural anemia were significantly associated AKI and 1‐year mortality. © 2015 Wiley Periodicals, Inc.]]></abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25641110</pmid><doi>10.1002/ccd.25832</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9127-348X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1522-1946 |
| ispartof | Catheterization and cardiovascular interventions, 2015-06, Vol.85 (7), p.1231-1239 |
| issn | 1522-1946 1522-726X |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01282355v1 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | acute kidney injury Acute Kidney Injury - diagnosis Acute Kidney Injury - epidemiology Acute Kidney Injury - mortality Aged Aged, 80 and over anemia Anemia - blood Anemia - diagnosis Anemia - epidemiology Anemia - mortality Aortic Valve - physiopathology Aortic Valve Stenosis - diagnosis Aortic Valve Stenosis - mortality Aortic Valve Stenosis - physiopathology Aortic Valve Stenosis - therapy Biomarkers - blood Cardiac Catheterization - adverse effects Cardiac Catheterization - instrumentation Cardiac Catheterization - mortality Chi-Square Distribution Female France - epidemiology Heart Valve Prosthesis Implantation - adverse effects Heart Valve Prosthesis Implantation - instrumentation Heart Valve Prosthesis Implantation - mortality Hemoglobins - metabolism Humans Incidence Kaplan-Meier Estimate Life Sciences Logistic Models Male Multivariate Analysis Proportional Hazards Models Registries Risk Factors severe symptomatic aortic stenosis Severity of Illness Index Time Factors transcatheter aortic valve implantation Treatment Outcome |
| title | Impact of pre- and post-procedural anemia on the incidence of acute kidney injury and 1-year mortality in patients undergoing transcatheter aortic valve implantation (from the French Aortic National CoreValve and Edwards 2 [FRANCE 2] Registry) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T17%3A21%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20pre-%20and%20post-procedural%20anemia%20on%20the%20incidence%20of%20acute%20kidney%20injury%20and%201-year%20mortality%20in%20patients%20undergoing%20transcatheter%20aortic%20valve%20implantation%20(from%20the%20French%20Aortic%20National%20CoreValve%20and%20Edwards%202%20%5BFRANCE%202%5D%20Registry)&rft.jtitle=Catheterization%20and%20cardiovascular%20interventions&rft.au=Arai,%20Takahide&rft.aucorp=FRANCE%202%20Registry%20Investigators&rft.date=2015-06&rft.volume=85&rft.issue=7&rft.spage=1231&rft.epage=1239&rft.pages=1231-1239&rft.issn=1522-1946&rft.eissn=1522-726X&rft.coden=CARIF2&rft_id=info:doi/10.1002/ccd.25832&rft_dat=%3Cproquest_hal_p%3E3691555821%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1682347583&rft_id=info:pmid/25641110&rfr_iscdi=true |