Chlordecone potentiates hepatic fibrosis in chronic liver injury induced by carbon tetrachloride in mice

•Hepatic impact of chronic co-exposure to chlordecone and CCl4 investigated in mouse model.•Chlordecone enhances the liver damage in CCl4 murine chronic hepatitis.•Chlordecone enhances the progression of liver fibrosis in mice. Chronic liver damage due to viral or chemical agents leads to a repair p...

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Veröffentlicht in:	Toxicology letters 2016-07, Vol.255, p.1-10
Hauptverfasser:	Tabet, Elise, Genet, Valentine, Tiaho, François, Lucas-Clerc, Catherine, Gelu-Simeon, Moana, Piquet-Pellorce, Claire, Samson, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Biomarkers - blood Carbon Tetrachloride CCl4 Chemical and Drug Induced Liver Injury, Chronic - etiology Chemical and Drug Induced Liver Injury, Chronic - genetics Chemical and Drug Induced Liver Injury, Chronic - metabolism Chemical and Drug Induced Liver Injury, Chronic - pathology Chlordecone Chlordecone - toxicity Collagen Damage Disease Progression Ecotoxicology Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Fibrosis Gene expression Gene Expression Regulation Genes Human health and pathology Hépatology and Gastroenterology Injuries Insecticides - toxicity Kepone Life Sciences Liver Liver - drug effects Liver - metabolism Liver - pathology Liver Cirrhosis, Experimental - chemically induced Liver Cirrhosis, Experimental - genetics Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - pathology Male Mice Mice, Inbred C57BL Time Factors Toxicology
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