Phosphorus limitation strategy to increase propionic acid flux towards 3-hydroxyvaleric acid monomers in Cupriavidus necator

•Carbon distribution of propionic acid between 3HB and 3HV monomers was investigated.•Limiting phosphorus feeding leads to a maximum of 33% (Mole.Mole−1) of 3HV.•Phosphorus deficiency leads to an instant production of up to 100% of 3HV.•But the increase in phosphorus limitation degree decreases PHA...

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Veröffentlicht in:	Bioresource technology 2014-02, Vol.153, p.206-215
Hauptverfasser:	Grousseau, Estelle, Blanchet, Elise, Déléris, Stéphane, Albuquerque, Maria G.E., Paul, Etienne, Uribelarrea, Jean-Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid - metabolism Batch Cell Culture Techniques Biological and medical sciences Butyric acid Butyric Acid - metabolism Carbon Carbon - pharmacology Computer Simulation Constraining Culture Cupriavidus necator Cupriavidus necator - drug effects Cupriavidus necator - growth & development Cupriavidus necator - metabolism Fatty Acids, Volatile - metabolism Fundamental and applied biological sciences. Psychology Life Sciences Metabolic Networks and Pathways - drug effects Monomers Nitrogen - pharmacology Oxygen - pharmacology Pentanoic Acids - metabolism Phosphorus Phosphorus - pharmacology Phosphorus limitation Polyhydroxybutyrate-co-hydroxyvalerate P(3HB-co-3HV) Propionates - metabolism Propionic acid Strategy Volatile fatty acids (VFA)
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