Deafferentation in thalamic and pontine areas in severe traumatic brain injury
Summary Purpose Severe traumatic brain injury (TBI) is characterized mainly by diffuse axonal injuries (DAI). The cortico-subcortical disconnections induced by such fiber disruption play a central role in consciousness recovery. We hypothesized that these cortico-subcortical deafferentations inferre...
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| Veröffentlicht in: | Journal of neuroradiology 2015-07, Vol.42 (4), p.202-211 |
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| creator | Laouchedi, M Galanaud, D Delmaire, C Fernandez-Vidal, S Messé, A Mesmoudi, S Oulebsir Boumghar, F Pélégrini-Issac, M Puybasset, L Benali, H Perlbarg, V |
| description | Summary Purpose Severe traumatic brain injury (TBI) is characterized mainly by diffuse axonal injuries (DAI). The cortico-subcortical disconnections induced by such fiber disruption play a central role in consciousness recovery. We hypothesized that these cortico-subcortical deafferentations inferred from diffusion MRI data could differentiate between TBI patients with favorable or unfavorable (death, vegetative state, or minimally conscious state) outcome one year after injury. Methods Cortico-subcortical fiber density maps were derived by using probabilistic tractography from diffusion tensor imaging data acquired in 24 severe TBI patients and 9 healthy controls. These maps were compared between patients and controls as well as between patients with favorable (FO) and unfavorable (UFO) 1-year outcome to identify the thalamo-cortical and ponto-thalamo-cortical pathways involved in the maintenance of consciousness. Results Thalamo-cortical and ponto-thalamo-cortical fiber density was significantly lower in TBI patients than in healthy controls. Comparing FO and UFO TBI patients showed thalamo-cortical deafferentation associated with unfavorable outcome for projections from ventral posterior and intermediate thalamic nuclei to the associative frontal, sensorimotor and associative temporal cortices. Specific ponto-thalamic deafferentation in projections from the upper dorsal pons (including the reticular formation) was also associated with unfavorable outcome. Conclusion Fiber density of cortico-subcortical pathways as measured from diffusion MRI tractography is a relevant candidate biomarker for early prediction of one-year favorable outcome in severe TBI. |
| doi_str_mv | 10.1016/j.neurad.2014.03.001 |
| format | Article |
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The cortico-subcortical disconnections induced by such fiber disruption play a central role in consciousness recovery. We hypothesized that these cortico-subcortical deafferentations inferred from diffusion MRI data could differentiate between TBI patients with favorable or unfavorable (death, vegetative state, or minimally conscious state) outcome one year after injury. Methods Cortico-subcortical fiber density maps were derived by using probabilistic tractography from diffusion tensor imaging data acquired in 24 severe TBI patients and 9 healthy controls. These maps were compared between patients and controls as well as between patients with favorable (FO) and unfavorable (UFO) 1-year outcome to identify the thalamo-cortical and ponto-thalamo-cortical pathways involved in the maintenance of consciousness. Results Thalamo-cortical and ponto-thalamo-cortical fiber density was significantly lower in TBI patients than in healthy controls. Comparing FO and UFO TBI patients showed thalamo-cortical deafferentation associated with unfavorable outcome for projections from ventral posterior and intermediate thalamic nuclei to the associative frontal, sensorimotor and associative temporal cortices. Specific ponto-thalamic deafferentation in projections from the upper dorsal pons (including the reticular formation) was also associated with unfavorable outcome. Conclusion Fiber density of cortico-subcortical pathways as measured from diffusion MRI tractography is a relevant candidate biomarker for early prediction of one-year favorable outcome in severe TBI.</description><identifier>ISSN: 0150-9861</identifier><identifier>DOI: 10.1016/j.neurad.2014.03.001</identifier><identifier>PMID: 24997478</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Adolescent ; Adult ; Aged ; Alleles ; Bioengineering ; Central Nervous System Diseases ; Child ; Child, Preschool ; Computer Science ; Computer Vision and Pattern Recognition ; Diffuse Axonal Injury - pathology ; Diffusion MRI ; Diffusion Tensor Imaging - methods ; DNA-Directed DNA Polymerase ; Electrodiagnosis ; Electroencephalography ; Engineering Sciences ; Female ; Humans ; Image Interpretation, Computer-Assisted - methods ; Image Processing ; Imaging ; Infant ; Infant, Newborn ; Life Sciences ; Magnetic Resonance Imaging ; Male ; Medical Imaging ; Middle Aged ; Mitochondria ; Mitochondrial Diseases ; Mutation ; Neurobiology ; Neurons and Cognition ; Pons ; Pons - injuries ; Pons - pathology ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Signal and Image processing ; Thalamus ; Thalamus - injuries ; Thalamus - pathology ; Tractography ; Traumatic brain injury ; White Matter - injuries ; White Matter - pathology ; Young Adult</subject><ispartof>Journal of neuroradiology, 2015-07, Vol.42 (4), p.202-211</ispartof><rights>Elsevier Masson SAS</rights><rights>2014 Elsevier Masson SAS</rights><rights>Copyright © 2014 Elsevier Masson SAS. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-b865fb2fa02d3b900ff21aa49b36a68619d0d6200d43179bab4cddb69f5a116b3</citedby><cites>FETCH-LOGICAL-c521t-b865fb2fa02d3b900ff21aa49b36a68619d0d6200d43179bab4cddb69f5a116b3</cites><orcidid>0000-0002-9285-8121 ; 0000-0001-5682-2917</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0150986114001801$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24997478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inria.hal.science/hal-01251644$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Laouchedi, M</creatorcontrib><creatorcontrib>Galanaud, D</creatorcontrib><creatorcontrib>Delmaire, C</creatorcontrib><creatorcontrib>Fernandez-Vidal, S</creatorcontrib><creatorcontrib>Messé, A</creatorcontrib><creatorcontrib>Mesmoudi, S</creatorcontrib><creatorcontrib>Oulebsir Boumghar, F</creatorcontrib><creatorcontrib>Pélégrini-Issac, M</creatorcontrib><creatorcontrib>Puybasset, L</creatorcontrib><creatorcontrib>Benali, H</creatorcontrib><creatorcontrib>Perlbarg, V</creatorcontrib><title>Deafferentation in thalamic and pontine areas in severe traumatic brain injury</title><title>Journal of neuroradiology</title><addtitle>J Neuroradiol</addtitle><description>Summary Purpose Severe traumatic brain injury (TBI) is characterized mainly by diffuse axonal injuries (DAI). The cortico-subcortical disconnections induced by such fiber disruption play a central role in consciousness recovery. We hypothesized that these cortico-subcortical deafferentations inferred from diffusion MRI data could differentiate between TBI patients with favorable or unfavorable (death, vegetative state, or minimally conscious state) outcome one year after injury. Methods Cortico-subcortical fiber density maps were derived by using probabilistic tractography from diffusion tensor imaging data acquired in 24 severe TBI patients and 9 healthy controls. These maps were compared between patients and controls as well as between patients with favorable (FO) and unfavorable (UFO) 1-year outcome to identify the thalamo-cortical and ponto-thalamo-cortical pathways involved in the maintenance of consciousness. Results Thalamo-cortical and ponto-thalamo-cortical fiber density was significantly lower in TBI patients than in healthy controls. Comparing FO and UFO TBI patients showed thalamo-cortical deafferentation associated with unfavorable outcome for projections from ventral posterior and intermediate thalamic nuclei to the associative frontal, sensorimotor and associative temporal cortices. Specific ponto-thalamic deafferentation in projections from the upper dorsal pons (including the reticular formation) was also associated with unfavorable outcome. Conclusion Fiber density of cortico-subcortical pathways as measured from diffusion MRI tractography is a relevant candidate biomarker for early prediction of one-year favorable outcome in severe TBI.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Bioengineering</subject><subject>Central Nervous System Diseases</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Computer Science</subject><subject>Computer Vision and Pattern Recognition</subject><subject>Diffuse Axonal Injury - pathology</subject><subject>Diffusion MRI</subject><subject>Diffusion Tensor Imaging - methods</subject><subject>DNA-Directed DNA Polymerase</subject><subject>Electrodiagnosis</subject><subject>Electroencephalography</subject><subject>Engineering Sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Image Processing</subject><subject>Imaging</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical Imaging</subject><subject>Middle Aged</subject><subject>Mitochondria</subject><subject>Mitochondrial Diseases</subject><subject>Mutation</subject><subject>Neurobiology</subject><subject>Neurons and Cognition</subject><subject>Pons</subject><subject>Pons - injuries</subject><subject>Pons - pathology</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Signal and Image processing</subject><subject>Thalamus</subject><subject>Thalamus - injuries</subject><subject>Thalamus - pathology</subject><subject>Tractography</subject><subject>Traumatic brain injury</subject><subject>White Matter - injuries</subject><subject>White Matter - pathology</subject><subject>Young Adult</subject><issn>0150-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhnMA0VJ4A4RyhMOGGcdxNhekqgVaaQUH4GxN7IlwSJzFTlbat8dR2h64cLJkf__v0TdZ9gahQED1oS88L4FsIQBlAWUBgM-yS8AKds1e4UX2MsYeQCBK8SK7ELJpalnvL7Ovt0xdx4H9TLObfO58Pv-igUZncvI2P05-dp5zCkxxfY18Sng-B1rGFDF5G8ituX4J51fZ846GyK8fzqvs5-dPP27udodvX-5vrg87Uwmcd-1eVV0rOgJhy7YB6DqBRLJpS0UqDdxYsEoAWFli3bTUSmNtq5quIkTVllfZ-603jaqPwY0Uznoip--uD3q9AxQVKilPmNh3G3sM05-F46xHFw0PA3melqhRNWVdQl2tqNxQE6YYA3dP3Qh6Na17vZnWq2kNpU6mU-ztww9LO7J9Cj1qTsDHDeDk5OQ46Ggce8PWBTaztpP73w__FpjBeWdo-M1njv20BJ98a9RRaNDf182vi0eZ0vtU8BcLA6dM</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Laouchedi, M</creator><creator>Galanaud, D</creator><creator>Delmaire, C</creator><creator>Fernandez-Vidal, S</creator><creator>Messé, A</creator><creator>Mesmoudi, S</creator><creator>Oulebsir Boumghar, F</creator><creator>Pélégrini-Issac, M</creator><creator>Puybasset, L</creator><creator>Benali, H</creator><creator>Perlbarg, V</creator><general>Elsevier Masson SAS</general><general>Elsevier Masson</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-9285-8121</orcidid><orcidid>https://orcid.org/0000-0001-5682-2917</orcidid></search><sort><creationdate>20150701</creationdate><title>Deafferentation in thalamic and pontine areas in severe traumatic brain injury</title><author>Laouchedi, M ; Galanaud, D ; Delmaire, C ; Fernandez-Vidal, S ; Messé, A ; Mesmoudi, S ; Oulebsir Boumghar, F ; Pélégrini-Issac, M ; Puybasset, L ; Benali, H ; Perlbarg, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-b865fb2fa02d3b900ff21aa49b36a68619d0d6200d43179bab4cddb69f5a116b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Bioengineering</topic><topic>Central Nervous System Diseases</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Computer Science</topic><topic>Computer Vision and Pattern Recognition</topic><topic>Diffuse Axonal Injury - pathology</topic><topic>Diffusion MRI</topic><topic>Diffusion Tensor Imaging - methods</topic><topic>DNA-Directed DNA Polymerase</topic><topic>Electrodiagnosis</topic><topic>Electroencephalography</topic><topic>Engineering Sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Image Processing</topic><topic>Imaging</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical Imaging</topic><topic>Middle Aged</topic><topic>Mitochondria</topic><topic>Mitochondrial Diseases</topic><topic>Mutation</topic><topic>Neurobiology</topic><topic>Neurons and Cognition</topic><topic>Pons</topic><topic>Pons - injuries</topic><topic>Pons - pathology</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Signal and Image processing</topic><topic>Thalamus</topic><topic>Thalamus - injuries</topic><topic>Thalamus - pathology</topic><topic>Tractography</topic><topic>Traumatic brain injury</topic><topic>White Matter - injuries</topic><topic>White Matter - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laouchedi, M</creatorcontrib><creatorcontrib>Galanaud, D</creatorcontrib><creatorcontrib>Delmaire, C</creatorcontrib><creatorcontrib>Fernandez-Vidal, S</creatorcontrib><creatorcontrib>Messé, A</creatorcontrib><creatorcontrib>Mesmoudi, S</creatorcontrib><creatorcontrib>Oulebsir Boumghar, F</creatorcontrib><creatorcontrib>Pélégrini-Issac, M</creatorcontrib><creatorcontrib>Puybasset, L</creatorcontrib><creatorcontrib>Benali, H</creatorcontrib><creatorcontrib>Perlbarg, V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laouchedi, M</au><au>Galanaud, D</au><au>Delmaire, C</au><au>Fernandez-Vidal, S</au><au>Messé, A</au><au>Mesmoudi, S</au><au>Oulebsir Boumghar, F</au><au>Pélégrini-Issac, M</au><au>Puybasset, L</au><au>Benali, H</au><au>Perlbarg, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deafferentation in thalamic and pontine areas in severe traumatic brain injury</atitle><jtitle>Journal of neuroradiology</jtitle><addtitle>J Neuroradiol</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>42</volume><issue>4</issue><spage>202</spage><epage>211</epage><pages>202-211</pages><issn>0150-9861</issn><abstract>Summary Purpose Severe traumatic brain injury (TBI) is characterized mainly by diffuse axonal injuries (DAI). The cortico-subcortical disconnections induced by such fiber disruption play a central role in consciousness recovery. We hypothesized that these cortico-subcortical deafferentations inferred from diffusion MRI data could differentiate between TBI patients with favorable or unfavorable (death, vegetative state, or minimally conscious state) outcome one year after injury. Methods Cortico-subcortical fiber density maps were derived by using probabilistic tractography from diffusion tensor imaging data acquired in 24 severe TBI patients and 9 healthy controls. These maps were compared between patients and controls as well as between patients with favorable (FO) and unfavorable (UFO) 1-year outcome to identify the thalamo-cortical and ponto-thalamo-cortical pathways involved in the maintenance of consciousness. Results Thalamo-cortical and ponto-thalamo-cortical fiber density was significantly lower in TBI patients than in healthy controls. Comparing FO and UFO TBI patients showed thalamo-cortical deafferentation associated with unfavorable outcome for projections from ventral posterior and intermediate thalamic nuclei to the associative frontal, sensorimotor and associative temporal cortices. Specific ponto-thalamic deafferentation in projections from the upper dorsal pons (including the reticular formation) was also associated with unfavorable outcome. Conclusion Fiber density of cortico-subcortical pathways as measured from diffusion MRI tractography is a relevant candidate biomarker for early prediction of one-year favorable outcome in severe TBI.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>24997478</pmid><doi>10.1016/j.neurad.2014.03.001</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9285-8121</orcidid><orcidid>https://orcid.org/0000-0001-5682-2917</orcidid></addata></record> |
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| subjects | Adolescent Adult Aged Alleles Bioengineering Central Nervous System Diseases Child Child, Preschool Computer Science Computer Vision and Pattern Recognition Diffuse Axonal Injury - pathology Diffusion MRI Diffusion Tensor Imaging - methods DNA-Directed DNA Polymerase Electrodiagnosis Electroencephalography Engineering Sciences Female Humans Image Interpretation, Computer-Assisted - methods Image Processing Imaging Infant Infant, Newborn Life Sciences Magnetic Resonance Imaging Male Medical Imaging Middle Aged Mitochondria Mitochondrial Diseases Mutation Neurobiology Neurons and Cognition Pons Pons - injuries Pons - pathology Radiology Reproducibility of Results Sensitivity and Specificity Signal and Image processing Thalamus Thalamus - injuries Thalamus - pathology Tractography Traumatic brain injury White Matter - injuries White Matter - pathology Young Adult |
| title | Deafferentation in thalamic and pontine areas in severe traumatic brain injury |
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