Recyclable Organocatalyst-Promoted One-Pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers

A recyclable fluorous bifunctional Cinchona alkaloid/thiourea‐catalyzed and four‐component Michael/Mannich/cyclization sequence has been developed for the asymmetric synthesis of spirooxindoles containing 2‐piperidinone and tetrahydropyridine rings. This one‐pot reaction process affords the products...

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Veröffentlicht in:Advanced synthesis & catalysis 2015-12, Vol.357 (18), p.3820-3824
Hauptverfasser: Huang, Xin, Pham, Kenny, Yi, Wenbin, Zhang, Xiaofeng, Clamens, Cécilia, Hyatt, Jeremy H., Jasinsk, Jerry P., Tayvah, Uriel, Zhang, Wei
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Sprache:eng
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