Recent advances in cancer treatment by iron chelators
[Display omitted] The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron depletion strategy based on metal chelation in the tumoral environment has been particularly studied in recent decades. After a short descrip...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2016-01, Vol.26 (2), p.251-256 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 26 |
| creator | Corcé, Vincent Gouin, Sébastien G. Renaud, Stéphanie Gaboriau, François Deniaud, David |
| description | [Display omitted]
The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron depletion strategy based on metal chelation in the tumoral environment has been particularly studied in recent decades. After a short description of the importance of iron for cancer cell proliferation, we will review the different iron chelators developed as potential chemotherapeutics. Finally, the recent efforts to vectorize the chelating agents specifically in the microtumoral environment will be discussed in detail. |
| doi_str_mv | 10.1016/j.bmcl.2015.11.094 |
| format | Article |
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The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron depletion strategy based on metal chelation in the tumoral environment has been particularly studied in recent decades. After a short description of the importance of iron for cancer cell proliferation, we will review the different iron chelators developed as potential chemotherapeutics. Finally, the recent efforts to vectorize the chelating agents specifically in the microtumoral environment will be discussed in detail.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2015.11.094</identifier><identifier>PMID: 26684852</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>8-Hydroxyquinoline ; Animals ; Antineoplastic Agents - therapeutic use ; Cancer ; Humans ; Iron ; Iron - metabolism ; Iron Chelating Agents - therapeutic use ; Life Sciences ; Metal chelators ; Neoplasms - drug therapy ; Polyamine ; Tumor vectorisation</subject><ispartof>Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.251-256</ispartof><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-2c29c9a8fc81815a4b96980f01c1c3dfa3464c38c791b6e47f97218141bc77123</citedby><cites>FETCH-LOGICAL-c434t-2c29c9a8fc81815a4b96980f01c1c3dfa3464c38c791b6e47f97218141bc77123</cites><orcidid>0000-0002-9117-1686 ; 0000-0003-2481-7608 ; 0000-0002-0985-1165 ; 0000-0002-0846-1798</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2015.11.094$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26684852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-rennes.hal.science/hal-01237081$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Corcé, Vincent</creatorcontrib><creatorcontrib>Gouin, Sébastien G.</creatorcontrib><creatorcontrib>Renaud, Stéphanie</creatorcontrib><creatorcontrib>Gaboriau, François</creatorcontrib><creatorcontrib>Deniaud, David</creatorcontrib><title>Recent advances in cancer treatment by iron chelators</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron depletion strategy based on metal chelation in the tumoral environment has been particularly studied in recent decades. After a short description of the importance of iron for cancer cell proliferation, we will review the different iron chelators developed as potential chemotherapeutics. Finally, the recent efforts to vectorize the chelating agents specifically in the microtumoral environment will be discussed in detail.</description><subject>8-Hydroxyquinoline</subject><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Cancer</subject><subject>Humans</subject><subject>Iron</subject><subject>Iron - metabolism</subject><subject>Iron Chelating Agents - therapeutic use</subject><subject>Life Sciences</subject><subject>Metal chelators</subject><subject>Neoplasms - drug therapy</subject><subject>Polyamine</subject><subject>Tumor vectorisation</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFFLwzAQx4Mobk6_gA_SR31ozaVpm4AvY6gTBoIo-BbSa8oy2nUm3WDf3pTNPfp0x93v_hw_Qm6BJkAhf1wlZYtNwihkCUBCJT8jY-A5j1NOs3MypjKnsZD8e0SuvF9RCpxyfklGLM8FFxkbk-zDoFn3ka52eo3GR3Yd4dC5qHdG9-2wLPeRdV1YLE2j-875a3JR68abm2OdkK-X58_ZPF68v77NposYecr7mCGTKLWoUYCATPNS5lLQmgICplWt0_AspgILCWVueFHLggWSQ4lFASydkIdD7lI3auNsq91eddqq-XShhhkNUEEF7CCw9wd247qfrfG9aq1H0zR6bbqtV1DkVEjBmAgoO6DoOu-dqU_ZQNWgVq3UoFYNahWACmrD0d0xf1u2pjqd_LkMwNMBMMHIzhqnPFoTVFbWGexV1dn_8n8BLDCHiQ</recordid><startdate>20160115</startdate><enddate>20160115</enddate><creator>Corcé, Vincent</creator><creator>Gouin, Sébastien G.</creator><creator>Renaud, Stéphanie</creator><creator>Gaboriau, François</creator><creator>Deniaud, David</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-9117-1686</orcidid><orcidid>https://orcid.org/0000-0003-2481-7608</orcidid><orcidid>https://orcid.org/0000-0002-0985-1165</orcidid><orcidid>https://orcid.org/0000-0002-0846-1798</orcidid></search><sort><creationdate>20160115</creationdate><title>Recent advances in cancer treatment by iron chelators</title><author>Corcé, Vincent ; Gouin, Sébastien G. ; Renaud, Stéphanie ; Gaboriau, François ; Deniaud, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-2c29c9a8fc81815a4b96980f01c1c3dfa3464c38c791b6e47f97218141bc77123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>8-Hydroxyquinoline</topic><topic>Animals</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Cancer</topic><topic>Humans</topic><topic>Iron</topic><topic>Iron - metabolism</topic><topic>Iron Chelating Agents - therapeutic use</topic><topic>Life Sciences</topic><topic>Metal chelators</topic><topic>Neoplasms - drug therapy</topic><topic>Polyamine</topic><topic>Tumor vectorisation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corcé, Vincent</creatorcontrib><creatorcontrib>Gouin, Sébastien G.</creatorcontrib><creatorcontrib>Renaud, Stéphanie</creatorcontrib><creatorcontrib>Gaboriau, François</creatorcontrib><creatorcontrib>Deniaud, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corcé, Vincent</au><au>Gouin, Sébastien G.</au><au>Renaud, Stéphanie</au><au>Gaboriau, François</au><au>Deniaud, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent advances in cancer treatment by iron chelators</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2016-01-15</date><risdate>2016</risdate><volume>26</volume><issue>2</issue><spage>251</spage><epage>256</epage><pages>251-256</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>[Display omitted]
The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron depletion strategy based on metal chelation in the tumoral environment has been particularly studied in recent decades. After a short description of the importance of iron for cancer cell proliferation, we will review the different iron chelators developed as potential chemotherapeutics. Finally, the recent efforts to vectorize the chelating agents specifically in the microtumoral environment will be discussed in detail.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26684852</pmid><doi>10.1016/j.bmcl.2015.11.094</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9117-1686</orcidid><orcidid>https://orcid.org/0000-0003-2481-7608</orcidid><orcidid>https://orcid.org/0000-0002-0985-1165</orcidid><orcidid>https://orcid.org/0000-0002-0846-1798</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.251-256 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 8-Hydroxyquinoline Animals Antineoplastic Agents - therapeutic use Cancer Humans Iron Iron - metabolism Iron Chelating Agents - therapeutic use Life Sciences Metal chelators Neoplasms - drug therapy Polyamine Tumor vectorisation |
| title | Recent advances in cancer treatment by iron chelators |
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