Structure of the light‐driven sodium pump KR2 and its implications for optogenetics

A key and common process present in organisms from all domains of life is the maintenance of the ion gradient between the inside and the outside of the cell. The gradient is generated by various active transporters, among which are the light‐driven ion pumps of the microbial rhodopsin family. Wherea...

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Veröffentlicht in:	The FEBS journal 2016-04, Vol.283 (7), p.1232-1238
Hauptverfasser:	Gushchin, Ivan, Shevchenko, Vitaly, Polovinkin, Vitaly, Borshchevskiy, Valentin, Buslaev, Pavel, Bamberg, Ernst, Gordeliy, Valentin
Format:	Artikel
Sprache:	eng
Schlagworte:	Atomic structure Binding Binding Sites - genetics Biochemistry, Molecular Biology Capping Cations Cellular biology crystal structure Crystallography, X-Ray Flexibility Genetics High resolution Holes Information processing Ion pumps Ion Transport - radiation effects Ions Life Sciences Light Light effects light‐driven Maintenance microbial rhodopsins Microbiology Microorganisms Models, Chemical Models, Molecular Mutants Mutation Na+/K+-exchanging ATPase Optics optogenetics tools Photolysis - radiation effects Potassium potassium pump Protein Engineering - methods Protein Multimerization Protein Structure, Secondary Protein Structure, Tertiary Pumping Pumps Retina Rhodopsin Selectivity Sodium Sodium - chemistry Sodium - metabolism sodium pump Sodium-Potassium-Exchanging ATPase - chemistry Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism Structural Biology Translocation
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