3D X-ray ultra-microscopy of bone tissue
We review the current X-ray techniques with 3D imaging capability at the nano-scale: transmission X-ray microscopy, ptychography and in-line phase nano-tomography. We further review the different ultra-structural features that have so far been resolved: the lacuno-canalicular network, collagen orien...
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| Veröffentlicht in: | Osteoporosis international 2016-02, Vol.27 (2), p.441-455 |
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| description | We review the current X-ray techniques with 3D imaging capability at the nano-scale: transmission X-ray microscopy, ptychography and in-line phase nano-tomography. We further review the different ultra-structural features that have so far been resolved: the lacuno-canalicular network, collagen orientation, nano-scale mineralization and their use as basis for mechanical simulations. X-ray computed tomography at the micro-metric scale is increasingly considered as the reference technique in imaging of bone micro-structure. The trend has been to push towards increasingly higher resolution. Due to the difficulty of realizing optics in the hard X-ray regime, the magnification has mainly been due to the use of visible light optics and indirect detection of the X-rays, which limits the attainable resolution with respect to the wavelength of the visible light used in detection. Recent developments in X-ray optics and instrumentation have allowed to implement several types of methods that achieve imaging that is limited in resolution by the X-ray wavelength, thus enabling computed tomography at the nano-scale. We review here the X-ray techniques with 3D imaging capability at the nano-scale: transmission X-ray microscopy, ptychography and in-line phase nano-tomography. Further, we review the different ultra-structural features that have so far been resolved and the applications that have been reported: imaging of the lacuno-canalicular network, direct analysis of collagen orientation, analysis of mineralization on the nano-scale and use of 3D images at the nano-scale to drive mechanical simulations. Finally, we discuss the issue of going beyond qualitative description to quantification of ultra-structural features. |
| doi_str_mv | 10.1007/s00198-015-3257-0 |
| format | Article |
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We further review the different ultra-structural features that have so far been resolved: the lacuno-canalicular network, collagen orientation, nano-scale mineralization and their use as basis for mechanical simulations. X-ray computed tomography at the micro-metric scale is increasingly considered as the reference technique in imaging of bone micro-structure. The trend has been to push towards increasingly higher resolution. Due to the difficulty of realizing optics in the hard X-ray regime, the magnification has mainly been due to the use of visible light optics and indirect detection of the X-rays, which limits the attainable resolution with respect to the wavelength of the visible light used in detection. Recent developments in X-ray optics and instrumentation have allowed to implement several types of methods that achieve imaging that is limited in resolution by the X-ray wavelength, thus enabling computed tomography at the nano-scale. We review here the X-ray techniques with 3D imaging capability at the nano-scale: transmission X-ray microscopy, ptychography and in-line phase nano-tomography. Further, we review the different ultra-structural features that have so far been resolved and the applications that have been reported: imaging of the lacuno-canalicular network, direct analysis of collagen orientation, analysis of mineralization on the nano-scale and use of 3D images at the nano-scale to drive mechanical simulations. 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We further review the different ultra-structural features that have so far been resolved: the lacuno-canalicular network, collagen orientation, nano-scale mineralization and their use as basis for mechanical simulations. X-ray computed tomography at the micro-metric scale is increasingly considered as the reference technique in imaging of bone micro-structure. The trend has been to push towards increasingly higher resolution. Due to the difficulty of realizing optics in the hard X-ray regime, the magnification has mainly been due to the use of visible light optics and indirect detection of the X-rays, which limits the attainable resolution with respect to the wavelength of the visible light used in detection. Recent developments in X-ray optics and instrumentation have allowed to implement several types of methods that achieve imaging that is limited in resolution by the X-ray wavelength, thus enabling computed tomography at the nano-scale. We review here the X-ray techniques with 3D imaging capability at the nano-scale: transmission X-ray microscopy, ptychography and in-line phase nano-tomography. Further, we review the different ultra-structural features that have so far been resolved and the applications that have been reported: imaging of the lacuno-canalicular network, direct analysis of collagen orientation, analysis of mineralization on the nano-scale and use of 3D images at the nano-scale to drive mechanical simulations. Finally, we discuss the issue of going beyond qualitative description to quantification of ultra-structural features.</description><subject>3-D technology</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - ultrastructure</subject><subject>Bones</subject><subject>Calcification, Physiologic</subject><subject>Collagen - ultrastructure</subject><subject>Endocrinology</subject><subject>Engineering Sciences</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy</subject><subject>Microscopy - methods</subject><subject>Nanotechnology - methods</subject><subject>Orthopedics</subject><subject>Review</subject><subject>Rheumatology</subject><subject>Signal and Image processing</subject><subject>Stress, Mechanical</subject><subject>Tissues</subject><subject>X-Ray Microtomography - methods</subject><subject>X-rays</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUtLxDAUhYMoOj5-gBspuNFF9N6kaZKljE8YcKMwu5B2Eq10pmMyFebfm1IdRBBcXUi-e3JyDiHHCBcIIC8jAGpFAQXlTEgKW2SEOeeU6UJskxFoLqnOcbpH9mN8g7Sjtdwle6zgEhQrRuSMX2dTGuw665pVsHReV6GNVbtcZ63PynbhslUdY-cOyY63TXRHX_OAPN_ePI3v6eTx7mF8NaGVAL2iWHqttPfCaV9aJb1VSgArq1yhZHkaHGcz9FKWXIgZL6VDm9yKqvKstIIfkPNB99U2ZhnquQ1r09ra3F9NTH8GyJgqNH5gYs8Gdhna987FlZnXsXJNYxeu7aJBWQidMkiZ_APtQ5PQq57-Qt_aLizSpw0qpkWRM-gFcaD6vGJwfmMWwfTtmKGd5FeYvh0DaefkS7kr52622fiuIwFsAGK6Wry48OPpP1U_AU4dlhQ</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Langer, M.</creator><creator>Peyrin, F.</creator><general>Springer London</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5821-9617</orcidid><orcidid>https://orcid.org/0000-0002-1988-3435</orcidid></search><sort><creationdate>20160201</creationdate><title>3D X-ray ultra-microscopy of bone tissue</title><author>Langer, M. ; Peyrin, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-1bf989ff5e9fba87fa88502bc481724c4831dd1f77b355d3b7e1a9655ccf2ba53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>3-D technology</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - ultrastructure</topic><topic>Bones</topic><topic>Calcification, Physiologic</topic><topic>Collagen - ultrastructure</topic><topic>Endocrinology</topic><topic>Engineering Sciences</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy</topic><topic>Microscopy - methods</topic><topic>Nanotechnology - methods</topic><topic>Orthopedics</topic><topic>Review</topic><topic>Rheumatology</topic><topic>Signal and Image processing</topic><topic>Stress, Mechanical</topic><topic>Tissues</topic><topic>X-Ray Microtomography - methods</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Langer, M.</creatorcontrib><creatorcontrib>Peyrin, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Langer, M.</au><au>Peyrin, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3D X-ray ultra-microscopy of bone tissue</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>27</volume><issue>2</issue><spage>441</spage><epage>455</epage><pages>441-455</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>We review the current X-ray techniques with 3D imaging capability at the nano-scale: transmission X-ray microscopy, ptychography and in-line phase nano-tomography. 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| subjects | 3-D technology Bone and Bones - diagnostic imaging Bone and Bones - ultrastructure Bones Calcification, Physiologic Collagen - ultrastructure Endocrinology Engineering Sciences Humans Imaging, Three-Dimensional - methods Medicine Medicine & Public Health Microscopy Microscopy - methods Nanotechnology - methods Orthopedics Review Rheumatology Signal and Image processing Stress, Mechanical Tissues X-Ray Microtomography - methods X-rays |
| title | 3D X-ray ultra-microscopy of bone tissue |
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