Highly Enantioselective Acylation of Acyclic Meso 1,3-Diols through Synergistic Isothiourea-Catalyzed Desymmetrization/Chiroablative Kinetic Resolution

A general and highly efficient organocatalyzed desymmetrization of acyclic meso 1,3-diols through acyl transfer using chiral isothioureas is described. The introduction of π-systems in the acyclic substrates provided new opportunities in terms of reactivity, enantioselectivity and synthetic potentia...

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Veröffentlicht in:	Organic letters 2015-05, Vol.17 (9), p.2118-2121
Hauptverfasser:	Merad, Jérémy, Borkar, Prashant, Bouyon Yenda, Tracy, Roux, Christèle, Pons, Jean-Marc, Parrain, Jean-Luc, Chuzel, Olivier, Bressy, Cyril
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Alcohols - chemistry Catalysis Chemical Sciences Diarylheptanoids - chemical synthesis Diarylheptanoids - chemistry Kinetics Molecular Structure Organic chemistry Pyrans Stereoisomerism Thiourea - chemistry
Online-Zugang:	Volltext
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