Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial

Summary Background Hospital-acquired pneumonia is common after traumatic brain injury, and might be partly a result of traumatic brain injury-induced adrenal insufficiency. We tested the efficacy of low-dose hydrocortisone with fludrocortisone for the prevention of hospital-acquired pneumonia. Metho...

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Veröffentlicht in:	The lancet respiratory medicine 2014-09, Vol.2 (9), p.706-716
Hauptverfasser:	Asehnoune, Karim, Dr, Seguin, Philippe, MD, Allary, Jeremy, MD, Feuillet, Fanny, MSc, Lasocki, Sigismond, MD, Cook, Fabrice, MD, Floch, Hervé, MD, Chabanne, Russell, MD, Geeraerts, Thomas, MD, Roger, Claire, MD, Perrigault, Pierre F, MD, Hanouz, Jean L, MD, Lukaszewicz, Anne C, MD, Biais, Matthieu, MD, Boucheix, Perrine, MD, Dahyot-Fizelier, Claire, MD, Capdevila, Xavier, MD, Mahe, Pierre J, MD, Maguet, Pascale Le, MD, Paugam-Burtz, Catherine, MD, Gergaud, Soizic, MD, Plaud, Benoit, MD, Constantin, Jean M, MD, Malledant, Yannick, MD, Flet, Laurent, PharmD, Sebille, Véronique, PhD, Roquilly, Antoine, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenal Insufficiency - blood Adult Aged Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Brain Injuries - complications Double-Blind Method Female Fludrocortisone - therapeutic use Humans Hydrocortisone - blood Hydrocortisone - therapeutic use Intensive Care Units Intention to Treat Analysis Life Sciences Male Middle Aged Pneumonia, Ventilator-Associated - etiology Pneumonia, Ventilator-Associated - prevention & control Pulmonary/Respiratory Young Adult
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