Raman spectroscopy for screening and diagnosis of cervical cancer
Cervical cancer is the fourth most common cancer in women worldwide and mainly affects younger women. The mortality associated with cervical cancer can be reduced if the disease is detected at the pre-cancer stage. Current best-practice methods include cytopathology, HPV testing, and histopathology,...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2015-11, Vol.407 (27), p.8279-8289 |
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| creator | Lyng, Fiona M. Traynor, Damien Ramos, Inês R. M. Bonnier, Franck Byrne, Hugh J. |
| description | Cervical cancer is the fourth most common cancer in women worldwide and mainly affects younger women. The mortality associated with cervical cancer can be reduced if the disease is detected at the pre-cancer stage. Current best-practice methods include cytopathology, HPV testing, and histopathology, but these methods are limited in terms of subjectivity, cost, and time. There is an unmet clinical need for new methods to aid clinicians in the early detection of cervical pre-cancer. These methods should be objective and rapid and require minimal sample preparation. Raman spectroscopy is a vibrational spectroscopic technique by which incident radiation is used to induce vibrations in the molecules of a sample and the scattered radiation may be used to characterise the sample in a rapid and non-destructive manner. Raman spectroscopy is sensitive to subtle biochemical changes occurring at the molecular level, enabling spectral variations corresponding to disease onset to be detected. Over the past 15 years, there have been numerous reports revealing the potential of Raman spectroscopy together with multivariate statistical analysis for the detection of a variety of cancers. This paper discusses the recent advances and challenges for cervical-cancer screening and diagnosis and offers some perspectives for the future. |
| doi_str_mv | 10.1007/s00216-015-8946-1 |
| format | Article |
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Raman spectroscopy is a vibrational spectroscopic technique by which incident radiation is used to induce vibrations in the molecules of a sample and the scattered radiation may be used to characterise the sample in a rapid and non-destructive manner. Raman spectroscopy is sensitive to subtle biochemical changes occurring at the molecular level, enabling spectral variations corresponding to disease onset to be detected. Over the past 15 years, there have been numerous reports revealing the potential of Raman spectroscopy together with multivariate statistical analysis for the detection of a variety of cancers. 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M.</creatorcontrib><creatorcontrib>Bonnier, Franck</creatorcontrib><creatorcontrib>Byrne, Hugh J.</creatorcontrib><title>Raman spectroscopy for screening and diagnosis of cervical cancer</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Cervical cancer is the fourth most common cancer in women worldwide and mainly affects younger women. The mortality associated with cervical cancer can be reduced if the disease is detected at the pre-cancer stage. Current best-practice methods include cytopathology, HPV testing, and histopathology, but these methods are limited in terms of subjectivity, cost, and time. There is an unmet clinical need for new methods to aid clinicians in the early detection of cervical pre-cancer. These methods should be objective and rapid and require minimal sample preparation. Raman spectroscopy is a vibrational spectroscopic technique by which incident radiation is used to induce vibrations in the molecules of a sample and the scattered radiation may be used to characterise the sample in a rapid and non-destructive manner. Raman spectroscopy is sensitive to subtle biochemical changes occurring at the molecular level, enabling spectral variations corresponding to disease onset to be detected. Over the past 15 years, there have been numerous reports revealing the potential of Raman spectroscopy together with multivariate statistical analysis for the detection of a variety of cancers. This paper discusses the recent advances and challenges for cervical-cancer screening and diagnosis and offers some perspectives for the future.</description><subject>Alphapapillomavirus - isolation & purification</subject><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Bioengineering</subject><subject>Cancer</subject><subject>Cancer screening</subject><subject>Cervical cancer</subject><subject>Cervix Uteri - pathology</subject><subject>Cervix Uteri - virology</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical Sciences</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Food Science</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Life Sciences</subject><subject>Methods</subject><subject>Monitoring/Environmental Analysis</subject><subject>Papillomavirus Infections - diagnosis</subject><subject>Papillomavirus Infections - pathology</subject><subject>Raman spectroscopy</subject><subject>Raman4Clinics</subject><subject>Review</subject><subject>Sample preparation</subject><subject>Samples</subject><subject>Screening</subject><subject>Spectra</subject><subject>Spectroscopy</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkt9rFDEQxxdRbK3-Ab7Igi_6sO0km5-PR1ErHAilPodpkj1TdpMzuSv0v2-WbY8qCiUPmZl8Zki--TbNewKnBECeFQBKRAeEd0oz0ZEXzTERRHVUcHh5iBk9at6UcgMVVES8bo6ooFISxY-b1SVOGNuy9XaXU7Fpe9cOKbfFZu9jiJsWo2tdwE1MJZQ2Da31-TZYHFuLscZvm1cDjsW_e9hPmp9fv1ydX3TrH9--n6_WnRVK7zrpJJPINBAnJGgEVvP-mlJnEeUAXqF2DDUHYUEM3KFzTNKeWwbKatufNJ-Xub9wNNscJsx3JmEwF6u1mWtAKFG9Jreksp8WdpvT770vOzOFYv04YvRpXwyREvpeaEWfgTKhFCjNn4FSyijlQlX041_oTdrnWPWZKaKkFPCE2uDoTYhD2mW081CzYj3hginOKnX6D6ou56dgU_RDqPU_GsjSYOuPluyHg1wEzGwcsxinKsbNbBwzK_bh4cL768m7Q8ejUypAF6DUo7jx-cmL_jv1HpYYyGQ</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Lyng, Fiona M.</creator><creator>Traynor, Damien</creator><creator>Ramos, Inês R. 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| subjects | Alphapapillomavirus - isolation & purification Analytical Chemistry Biochemistry Bioengineering Cancer Cancer screening Cervical cancer Cervix Uteri - pathology Cervix Uteri - virology Characterization and Evaluation of Materials Chemical Sciences Chemistry Chemistry and Materials Science Diagnosis Female Food Science Histopathology Humans Laboratory Medicine Life Sciences Methods Monitoring/Environmental Analysis Papillomavirus Infections - diagnosis Papillomavirus Infections - pathology Raman spectroscopy Raman4Clinics Review Sample preparation Samples Screening Spectra Spectroscopy Spectrum Analysis, Raman - methods Statistical analysis Statistical methods Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - virology |
| title | Raman spectroscopy for screening and diagnosis of cervical cancer |
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