High ambient temperature alleviates the inflammatory response and growth depression in pigs challenged with Escherichia coli lipopolysaccharide
Pig production has increased in hot climate countries over recent years, but the effect of exposure to high temperatures on the health status of farm animals has not been investigated thoroughly. It is not clear how the ambient temperature (Ta) might influence responses to inflammatory challenge in...
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Veröffentlicht in: | The veterinary journal (1997) 2014-06, Vol.200 (3), p.404-409 |
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creator | Campos, Paulo H.R.F. Merlot, Elodie Damon, Marie Noblet, Jean Le Floc'h, Nathalie |
description | Pig production has increased in hot climate countries over recent years, but the effect of exposure to high temperatures on the health status of farm animals has not been investigated thoroughly. It is not clear how the ambient temperature (Ta) might influence responses to inflammatory challenge in pigs. The aim of the present study was to evaluate the effects of high Ta on performance and physiological parameters of growing pigs, subjected to repeated administration of Escherichia coli lipopolysaccharide (LPS).
Thirty-seven pigs, each fitted with a jugular catheter, were assigned to one of two Ta conditions: thermo-neutral (TN, 24 °C) or high (HT, 30 °C). After a 14-day adaptation period, and a 7-day measurement period, pigs were administered five repeated injections of LPS at 48 h intervals. Irrespective of Ta, the LPS challenge reduced feed consumption and increased plasma pro-inflammatory cytokines, haptoglobin and cortisol. However, the extent of these responses was greater in pigs at TN than HT. In both groups, plasma thyroxine and triiodothyronine concentrations decreased, following the first LPS injection and thereafter returned to baseline, which occurred faster at HT than at TN. Moreover, the LPS challenge decreased growth and feed efficiency in pigs kept at TN, which was not observed in pigs kept at HT. The results suggest a greater capacity of pigs to limit the physiological and metabolic disturbances caused by inflammatory challenge, when kept at HT, compared to TN. |
doi_str_mv | 10.1016/j.tvjl.2014.04.001 |
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Thirty-seven pigs, each fitted with a jugular catheter, were assigned to one of two Ta conditions: thermo-neutral (TN, 24 °C) or high (HT, 30 °C). After a 14-day adaptation period, and a 7-day measurement period, pigs were administered five repeated injections of LPS at 48 h intervals. Irrespective of Ta, the LPS challenge reduced feed consumption and increased plasma pro-inflammatory cytokines, haptoglobin and cortisol. However, the extent of these responses was greater in pigs at TN than HT. In both groups, plasma thyroxine and triiodothyronine concentrations decreased, following the first LPS injection and thereafter returned to baseline, which occurred faster at HT than at TN. Moreover, the LPS challenge decreased growth and feed efficiency in pigs kept at TN, which was not observed in pigs kept at HT. The results suggest a greater capacity of pigs to limit the physiological and metabolic disturbances caused by inflammatory challenge, when kept at HT, compared to TN.</description><identifier>ISSN: 1090-0233</identifier><identifier>EISSN: 1532-2971</identifier><identifier>DOI: 10.1016/j.tvjl.2014.04.001</identifier><identifier>PMID: 24792207</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Escherichia coli ; Escherichia coli - chemistry ; Growing pigs ; Heat stress ; Hot Temperature - adverse effects ; Immunity, Innate ; Inflammation ; Life Sciences ; Lipopolysaccharide endotoxin ; Lipopolysaccharides - administration & dosage ; Lipopolysaccharides - pharmacology ; Swine - growth & development ; Swine - immunology ; Swine - physiology ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>The veterinary journal (1997), 2014-06, Vol.200 (3), p.404-409</ispartof><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-c2854b78e7c49998abc79da5605d8b353400c794a41759868aa9526c6ff9ca1f3</citedby><cites>FETCH-LOGICAL-c423t-c2854b78e7c49998abc79da5605d8b353400c794a41759868aa9526c6ff9ca1f3</cites><orcidid>0000-0001-9858-1584 ; 0000-0003-2300-0970</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tvjl.2014.04.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24792207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01210573$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Campos, Paulo H.R.F.</creatorcontrib><creatorcontrib>Merlot, Elodie</creatorcontrib><creatorcontrib>Damon, Marie</creatorcontrib><creatorcontrib>Noblet, Jean</creatorcontrib><creatorcontrib>Le Floc'h, Nathalie</creatorcontrib><title>High ambient temperature alleviates the inflammatory response and growth depression in pigs challenged with Escherichia coli lipopolysaccharide</title><title>The veterinary journal (1997)</title><addtitle>Vet J</addtitle><description>Pig production has increased in hot climate countries over recent years, but the effect of exposure to high temperatures on the health status of farm animals has not been investigated thoroughly. It is not clear how the ambient temperature (Ta) might influence responses to inflammatory challenge in pigs. The aim of the present study was to evaluate the effects of high Ta on performance and physiological parameters of growing pigs, subjected to repeated administration of Escherichia coli lipopolysaccharide (LPS).
Thirty-seven pigs, each fitted with a jugular catheter, were assigned to one of two Ta conditions: thermo-neutral (TN, 24 °C) or high (HT, 30 °C). After a 14-day adaptation period, and a 7-day measurement period, pigs were administered five repeated injections of LPS at 48 h intervals. Irrespective of Ta, the LPS challenge reduced feed consumption and increased plasma pro-inflammatory cytokines, haptoglobin and cortisol. However, the extent of these responses was greater in pigs at TN than HT. In both groups, plasma thyroxine and triiodothyronine concentrations decreased, following the first LPS injection and thereafter returned to baseline, which occurred faster at HT than at TN. Moreover, the LPS challenge decreased growth and feed efficiency in pigs kept at TN, which was not observed in pigs kept at HT. The results suggest a greater capacity of pigs to limit the physiological and metabolic disturbances caused by inflammatory challenge, when kept at HT, compared to TN.</description><subject>Animals</subject><subject>Escherichia coli</subject><subject>Escherichia coli - chemistry</subject><subject>Growing pigs</subject><subject>Heat stress</subject><subject>Hot Temperature - adverse effects</subject><subject>Immunity, Innate</subject><subject>Inflammation</subject><subject>Life Sciences</subject><subject>Lipopolysaccharide endotoxin</subject><subject>Lipopolysaccharides - administration & dosage</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Swine - growth & development</subject><subject>Swine - immunology</subject><subject>Swine - physiology</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>1090-0233</issn><issn>1532-2971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVGL1DAUhYso7rr6B3yQPOpDx5s0aRvwZVlWRxjwRZ9Dmt5OM6RNTTKzzK_wL2_KrPsowoUbDl8Oh3uK4j2FDQVafz5s0ungNgwo30AeoC-KayoqVjLZ0Jf5DRJKYFV1VbyJ8QAAknP2urhivJGMQXNd_Nna_Uj01FmcE0k4LRh0OgYk2jk8WZ0wkjQisfPg9DTp5MOZBIyLn2OG5p7sg39II-lxyXK0fs4sWew-EjOuJvMee_JgM3IfzYjBmtFqYryzxNnFL96dozaZDbbHt8WrQbuI7572TfHr6_3Pu225-_Ht-93trjScVak0rBW8a1psDJdStrozjey1qEH0bVeJigNkhWtOGyHbutVaClabehik0XSobopPF98cUS3BTjqclddWbW93atWAMgqiqU40sx8v7BL87yPGpCYbDTqnZ_THqKjgwFg-bf0fKGvbNkeCjLILaoKPMeDwHIOCWvtVB7X2q9Z-FeSBNcqHJ_9jN2H__OVvoRn4cgEwH-9kMahocrUGexvQJNV7-y__R7CEuMQ</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Campos, Paulo H.R.F.</creator><creator>Merlot, Elodie</creator><creator>Damon, Marie</creator><creator>Noblet, Jean</creator><creator>Le Floc'h, Nathalie</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-9858-1584</orcidid><orcidid>https://orcid.org/0000-0003-2300-0970</orcidid></search><sort><creationdate>20140601</creationdate><title>High ambient temperature alleviates the inflammatory response and growth depression in pigs challenged with Escherichia coli lipopolysaccharide</title><author>Campos, Paulo H.R.F. ; Merlot, Elodie ; Damon, Marie ; Noblet, Jean ; Le Floc'h, Nathalie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-c2854b78e7c49998abc79da5605d8b353400c794a41759868aa9526c6ff9ca1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Escherichia coli</topic><topic>Escherichia coli - chemistry</topic><topic>Growing pigs</topic><topic>Heat stress</topic><topic>Hot Temperature - adverse effects</topic><topic>Immunity, Innate</topic><topic>Inflammation</topic><topic>Life Sciences</topic><topic>Lipopolysaccharide endotoxin</topic><topic>Lipopolysaccharides - administration & dosage</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Swine - growth & development</topic><topic>Swine - immunology</topic><topic>Swine - physiology</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campos, Paulo H.R.F.</creatorcontrib><creatorcontrib>Merlot, Elodie</creatorcontrib><creatorcontrib>Damon, Marie</creatorcontrib><creatorcontrib>Noblet, Jean</creatorcontrib><creatorcontrib>Le Floc'h, Nathalie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The veterinary journal (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campos, Paulo H.R.F.</au><au>Merlot, Elodie</au><au>Damon, Marie</au><au>Noblet, Jean</au><au>Le Floc'h, Nathalie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High ambient temperature alleviates the inflammatory response and growth depression in pigs challenged with Escherichia coli lipopolysaccharide</atitle><jtitle>The veterinary journal (1997)</jtitle><addtitle>Vet J</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>200</volume><issue>3</issue><spage>404</spage><epage>409</epage><pages>404-409</pages><issn>1090-0233</issn><eissn>1532-2971</eissn><abstract>Pig production has increased in hot climate countries over recent years, but the effect of exposure to high temperatures on the health status of farm animals has not been investigated thoroughly. It is not clear how the ambient temperature (Ta) might influence responses to inflammatory challenge in pigs. The aim of the present study was to evaluate the effects of high Ta on performance and physiological parameters of growing pigs, subjected to repeated administration of Escherichia coli lipopolysaccharide (LPS).
Thirty-seven pigs, each fitted with a jugular catheter, were assigned to one of two Ta conditions: thermo-neutral (TN, 24 °C) or high (HT, 30 °C). After a 14-day adaptation period, and a 7-day measurement period, pigs were administered five repeated injections of LPS at 48 h intervals. Irrespective of Ta, the LPS challenge reduced feed consumption and increased plasma pro-inflammatory cytokines, haptoglobin and cortisol. However, the extent of these responses was greater in pigs at TN than HT. In both groups, plasma thyroxine and triiodothyronine concentrations decreased, following the first LPS injection and thereafter returned to baseline, which occurred faster at HT than at TN. Moreover, the LPS challenge decreased growth and feed efficiency in pigs kept at TN, which was not observed in pigs kept at HT. The results suggest a greater capacity of pigs to limit the physiological and metabolic disturbances caused by inflammatory challenge, when kept at HT, compared to TN.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24792207</pmid><doi>10.1016/j.tvjl.2014.04.001</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9858-1584</orcidid><orcidid>https://orcid.org/0000-0003-2300-0970</orcidid></addata></record> |
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subjects | Animals Escherichia coli Escherichia coli - chemistry Growing pigs Heat stress Hot Temperature - adverse effects Immunity, Innate Inflammation Life Sciences Lipopolysaccharide endotoxin Lipopolysaccharides - administration & dosage Lipopolysaccharides - pharmacology Swine - growth & development Swine - immunology Swine - physiology Thyroxine - blood Triiodothyronine - blood |
title | High ambient temperature alleviates the inflammatory response and growth depression in pigs challenged with Escherichia coli lipopolysaccharide |
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