High ambient temperature alleviates the inflammatory response and growth depression in pigs challenged with Escherichia coli lipopolysaccharide

Pig production has increased in hot climate countries over recent years, but the effect of exposure to high temperatures on the health status of farm animals has not been investigated thoroughly. It is not clear how the ambient temperature (Ta) might influence responses to inflammatory challenge in...

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Veröffentlicht in:The veterinary journal (1997) 2014-06, Vol.200 (3), p.404-409
Hauptverfasser: Campos, Paulo H.R.F., Merlot, Elodie, Damon, Marie, Noblet, Jean, Le Floc'h, Nathalie
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container_issue 3
container_start_page 404
container_title The veterinary journal (1997)
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creator Campos, Paulo H.R.F.
Merlot, Elodie
Damon, Marie
Noblet, Jean
Le Floc'h, Nathalie
description Pig production has increased in hot climate countries over recent years, but the effect of exposure to high temperatures on the health status of farm animals has not been investigated thoroughly. It is not clear how the ambient temperature (Ta) might influence responses to inflammatory challenge in pigs. The aim of the present study was to evaluate the effects of high Ta on performance and physiological parameters of growing pigs, subjected to repeated administration of Escherichia coli lipopolysaccharide (LPS). Thirty-seven pigs, each fitted with a jugular catheter, were assigned to one of two Ta conditions: thermo-neutral (TN, 24 °C) or high (HT, 30 °C). After a 14-day adaptation period, and a 7-day measurement period, pigs were administered five repeated injections of LPS at 48 h intervals. Irrespective of Ta, the LPS challenge reduced feed consumption and increased plasma pro-inflammatory cytokines, haptoglobin and cortisol. However, the extent of these responses was greater in pigs at TN than HT. In both groups, plasma thyroxine and triiodothyronine concentrations decreased, following the first LPS injection and thereafter returned to baseline, which occurred faster at HT than at TN. Moreover, the LPS challenge decreased growth and feed efficiency in pigs kept at TN, which was not observed in pigs kept at HT. The results suggest a greater capacity of pigs to limit the physiological and metabolic disturbances caused by inflammatory challenge, when kept at HT, compared to TN.
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In both groups, plasma thyroxine and triiodothyronine concentrations decreased, following the first LPS injection and thereafter returned to baseline, which occurred faster at HT than at TN. Moreover, the LPS challenge decreased growth and feed efficiency in pigs kept at TN, which was not observed in pigs kept at HT. 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subjects Animals
Escherichia coli
Escherichia coli - chemistry
Growing pigs
Heat stress
Hot Temperature - adverse effects
Immunity, Innate
Inflammation
Life Sciences
Lipopolysaccharide endotoxin
Lipopolysaccharides - administration & dosage
Lipopolysaccharides - pharmacology
Swine - growth & development
Swine - immunology
Swine - physiology
Thyroxine - blood
Triiodothyronine - blood
title High ambient temperature alleviates the inflammatory response and growth depression in pigs challenged with Escherichia coli lipopolysaccharide
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