Why bother using non-human primate models of cognitive disorders in translational research?
Although everyone would agree that successful translation of therapeutic candidates for central nervous disorders should involve non-human primate (nhp) models of cognitive disorders, we are left with the paucity of publications reporting either the target validation or the actual preclinical testin...
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| Veröffentlicht in: | Neurobiology of learning and memory 2015-10, Vol.124, p.123-129 |
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| creator | Camus, Sandrine Ko, Wai Kin D. Pioli, Elsa Bezard, Erwan |
| description | Although everyone would agree that successful translation of therapeutic candidates for central nervous disorders should involve non-human primate (nhp) models of cognitive disorders, we are left with the paucity of publications reporting either the target validation or the actual preclinical testing in heuristic nhp models. In this review, we discuss the importance of nhps in translational research, highlighting the advances in technological/methodological approaches for ‘bridging the gap’ between preclinical and clinical experiments. In this process, we acknowledge that nhps remain a vital tool for the investigation of complex cognitive functions, given their resemblance to humans in aspects of behaviour, anatomy and physiology. The recent improvements made for a suitable nhp model in cognitive research, including new surrogates of disease and application of innovative methodological approaches, are continuous strides for reaching efficient translation for human benefit. This will ultimately aid the development of innovative treatments against the current and future threat of neurological and psychiatric disorders to the global population. |
| doi_str_mv | 10.1016/j.nlm.2015.06.012 |
| format | Article |
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All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-9e7253504221f6f49656b007d4c52dc6d007ed7d523254af4e24a511b7e69683</citedby><cites>FETCH-LOGICAL-c584t-9e7253504221f6f49656b007d4c52dc6d007ed7d523254af4e24a511b7e69683</cites><orcidid>0000-0002-0410-4638</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1074742715001185$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26135120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01196889$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Camus, Sandrine</creatorcontrib><creatorcontrib>Ko, Wai Kin D.</creatorcontrib><creatorcontrib>Pioli, Elsa</creatorcontrib><creatorcontrib>Bezard, Erwan</creatorcontrib><title>Why bother using non-human primate models of cognitive disorders in translational research?</title><title>Neurobiology of learning and memory</title><addtitle>Neurobiol Learn Mem</addtitle><description>Although everyone would agree that successful translation of therapeutic candidates for central nervous disorders should involve non-human primate (nhp) models of cognitive disorders, we are left with the paucity of publications reporting either the target validation or the actual preclinical testing in heuristic nhp models. 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| subjects | Alzheimer Alzheimer Disease - physiopathology Animal cognition Animals Brain - physiopathology Cantab Cognition Disorders - genetics Cognition Disorders - physiopathology Depression Disease Models, Animal Ethology Humans Life Sciences Macaca Nervous system Neurobiology Non-human primate Parkinson Parkinson Disease - physiopathology Primates Species Specificity Transgenesis Translational Medical Research - methods |
| title | Why bother using non-human primate models of cognitive disorders in translational research? |
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