A protein phosphatase 2A complex spatially controls plant cell division
In the absence of cell migration, the orientation of cell divisions is crucial for body plan determination in plants. The position of the division plane in plant cells is set up premitotically via a transient cytoskeletal array, the preprophase band, which precisely delineates the cortical plane of...
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| Veröffentlicht in: | Nature communications 2013, Vol.4 (1), p.1863-1863, Article 1863 |
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| creator | Spinner, Lara Gadeyne, Astrid Belcram, Katia Goussot, Magali Moison, Michaël Duroc, Yann Eeckhout, Dominique De Winne, Nancy Schaefer, Estelle Van De Slijke, Eveline Persiau, Geert Witters, Erwin Gevaert, Kris De Jaeger, Geert Bouchez, David Van Damme, Daniël Pastuglia, Martine |
| description | In the absence of cell migration, the orientation of cell divisions is crucial for body plan determination in plants. The position of the division plane in plant cells is set up premitotically via a transient cytoskeletal array, the preprophase band, which precisely delineates the cortical plane of division. Here we describe a protein complex that targets protein phosphatase 2A activity to microtubules, regulating the transition from the interphase to the premitotic microtubule array. This complex, which comprises TONNEAU1 and a PP2A heterotrimeric holoenzyme with FASS as regulatory subunit, is recruited to the cytoskeleton via the TONNEAU1-recruiting motif family of proteins. Despite the acentrosomal nature of plant cells, all members of this complex share similarity with animal centrosomal proteins involved in ciliary and centriolar/centrosomal functions, revealing an evolutionary link between the cortical cytoskeleton of plant cells and microtubule organizers in other eukaryotes.
Spatial positioning of the division plane in plant cells is determined premitotically by the preprophase band of microtubules. Spinner
et al.
show that its formation in
Arabidopsis
requires a PP2A complex containing FASS and TON1 which is recruited to cortical microtubules by the TRM protein family. |
| doi_str_mv | 10.1038/ncomms2831 |
| format | Article |
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Spatial positioning of the division plane in plant cells is determined premitotically by the preprophase band of microtubules. Spinner
et al.
show that its formation in
Arabidopsis
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Spatial positioning of the division plane in plant cells is determined premitotically by the preprophase band of microtubules. Spinner
et al.
show that its formation in
Arabidopsis
requires a PP2A complex containing FASS and TON1 which is recruited to cortical microtubules by the TRM protein family.</description><subject>631/449/2675</subject><subject>631/449/448/1358</subject><subject>Alleles</subject><subject>Arabidopsis - cytology</subject><subject>Arabidopsis - enzymology</subject><subject>Arabidopsis - ultrastructure</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Cell Division</subject><subject>Germination</subject><subject>Humanities and Social Sciences</subject><subject>Isoenzymes - metabolism</subject><subject>Life Sciences</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Microtubules - metabolism</subject><subject>multidisciplinary</subject><subject>Multiprotein Complexes - metabolism</subject><subject>Mutation - genetics</subject><subject>Phenotype</subject><subject>Phosphoprotein Phosphatases - 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Spatial positioning of the division plane in plant cells is determined premitotically by the preprophase band of microtubules. Spinner
et al.
show that its formation in
Arabidopsis
requires a PP2A complex containing FASS and TON1 which is recruited to cortical microtubules by the TRM protein family.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23673648</pmid><doi>10.1038/ncomms2831</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6558-5669</orcidid><orcidid>https://orcid.org/0000-0002-5828-745X</orcidid><orcidid>https://orcid.org/0000-0003-3545-4339</orcidid><orcidid>https://orcid.org/0000-0002-5439-7491</orcidid><orcidid>https://orcid.org/0000-0001-5770-7670</orcidid><orcidid>https://orcid.org/0000-0002-4237-0283</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature communications, 2013, Vol.4 (1), p.1863-1863, Article 1863 |
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| subjects | 631/449/2675 631/449/448/1358 Alleles Arabidopsis - cytology Arabidopsis - enzymology Arabidopsis - ultrastructure Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Cell Division Germination Humanities and Social Sciences Isoenzymes - metabolism Life Sciences Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubules - metabolism multidisciplinary Multiprotein Complexes - metabolism Mutation - genetics Phenotype Phosphoprotein Phosphatases - metabolism Plant Cells - enzymology Prophase Protein Binding Protein Interaction Maps Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Science Science (multidisciplinary) Seedlings - ultrastructure |
| title | A protein phosphatase 2A complex spatially controls plant cell division |
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