Porous nanoparticles as delivery system of complex antigens for an effective vaccine against acute and chronic Toxoplasma gondii infection

Abstract Development of sub-unit mucosal vaccines requires the use of specific delivery systems or immune-modulators such as adjuvants to improve antigen immunogenicity. Nasal route for vaccine delivery by nanoparticles has attracted much interest but mechanisms triggering effective mucosal and syst...

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Veröffentlicht in:	Biomaterials 2015-05, Vol.50, p.164-175
Hauptverfasser:	Dimier-Poisson, Isabelle, Carpentier, Rodolphe, N'Guyen, Thi Thanh Loi, Dahmani, Fatima, Ducournau, Céline, Betbeder, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Administration, Intranasal Advanced Basic Science Airways Animals Antigens Antigens, Protozoan - administration & dosage Antigens, Protozoan - immunology Biomedical materials Cell Line Cellular Chronic Disease Delivery systems Dendritic Cells - metabolism Dentistry Epithelial Cells - cytology Epithelial Cells - metabolism Female Humans Immunity, Cellular Immunity, Humoral Immunomodulation Immunotherapy Leukocytes - metabolism Life Sciences Macrophages - metabolism Mice Microbiology and Parasitology Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Nasal immunization NF-kappa B - metabolism Particle Size Protozoan Vaccines - immunology Respiratory Mucosa - cytology Serum Albumin, Bovine - metabolism Static Electricity Surgical implants Toll-Like Receptors - metabolism Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis - immunology Toxoplasmosis - parasitology Vaccine Vaccines
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