Interferon gamma response to Mycobacterium avium subsp. paratuberculosis specific lipopentapeptide antigen L5P in cattle
After Mycobacterium avium subsp. paratuberculosis (Map) infection the cell-mediated immune (CMI) response indicative of early Th1 activation may be detected using interferon-gamma release assay (IGRA). Currently, the purified protein derivatives (PPDs), i.e., the total extract of mycobacteria antige...
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| Veröffentlicht in: | Research in veterinary science 2015-10, Vol.102, p.118-121 |
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| creator | Holbert, Sébastien Branger, Maxime Souriau, Armel Lamoureux, Bérénice Ganneau, Christelle Richard, Gaëlle Cochard, Thierry Tholoniat, Christophe Bay, Sylvie Winter, Nathalie Moyen, Jean Louis Biet, Franck |
| description | After Mycobacterium avium subsp. paratuberculosis (Map) infection the cell-mediated immune (CMI) response indicative of early Th1 activation may be detected using interferon-gamma release assay (IGRA). Currently, the purified protein derivatives (PPDs), i.e., the total extract of mycobacteria antigens are used to recall CMI responses against Map.
This study aimed to assess the ability of the chemically synthesized Map specific cell wall lipopentapeptide L5P to induce CMI response in cows infected by Map compared to PPD. L5P and PPD elicited an IFN-γ response in 12 and 35 animals from two Map infected herds respectively, but IFN-γ was not detected in the 13 cows recruited from a non-infected herd. Levels of IFN-γ detected were higher with PPD than with L5P. There was no correlation between the IFN-γ response and the humoral response to Map or faecal culture.
•Non-infected, Map infected and Mycobacterium bovis infected cattle herds recruited to explore whole blood CMI response•Chemically synthetized Map-specific antigen L5P tested in IGRA•L5P can induce CMI responses which can be quantified by assaying IFN-γ release in whole blood stimulation. |
| doi_str_mv | 10.1016/j.rvsc.2015.07.017 |
| format | Article |
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This study aimed to assess the ability of the chemically synthesized Map specific cell wall lipopentapeptide L5P to induce CMI response in cows infected by Map compared to PPD. L5P and PPD elicited an IFN-γ response in 12 and 35 animals from two Map infected herds respectively, but IFN-γ was not detected in the 13 cows recruited from a non-infected herd. Levels of IFN-γ detected were higher with PPD than with L5P. There was no correlation between the IFN-γ response and the humoral response to Map or faecal culture.
•Non-infected, Map infected and Mycobacterium bovis infected cattle herds recruited to explore whole blood CMI response•Chemically synthetized Map-specific antigen L5P tested in IGRA•L5P can induce CMI responses which can be quantified by assaying IFN-γ release in whole blood stimulation.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2015.07.017</identifier><identifier>PMID: 26412530</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antigen ; Antigens, Bacterial - immunology ; Cattle ; Cattle Diseases - immunology ; Cattle Diseases - microbiology ; Cell mediated immune response ; Female ; IFN-γ release assay: IGRA ; Immunity, Cellular - immunology ; Interferon-gamma - metabolism ; Johne's disease ; Life Sciences ; Lipopentapeptide: L5P ; Lipopeptide ; Microbiology and Parasitology ; Milk ; Mycobacterium avium subsp. paratuberculosis ; Mycobacterium avium subsp. paratuberculosis - immunology ; Mycobacterium avium subsp. paratuberculosis - metabolism ; Paratuberculosis ; Paratuberculosis - immunology ; Paratuberculosis - microbiology ; Tuberculin ; Tuberculosis ; Veterinary medicine ; Wildlife</subject><ispartof>Research in veterinary science, 2015-10, Vol.102, p.118-121</ispartof><rights>2015</rights><rights>Copyright © 2015. Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Limited Oct 2015</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-1e4e288eabcf1890d1dda4f56697247901a1f341dd8e1c5decdf432103c5c76e3</citedby><cites>FETCH-LOGICAL-c495t-1e4e288eabcf1890d1dda4f56697247901a1f341dd8e1c5decdf432103c5c76e3</cites><orcidid>0000-0003-3985-1753 ; 0000-0001-7655-3144 ; 0000-0002-5614-9504 ; 0000-0003-0994-7834 ; 0000-0001-8425-6158 ; 0000-0002-0982-5872</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0034528815300254$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26412530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01188322$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Holbert, Sébastien</creatorcontrib><creatorcontrib>Branger, Maxime</creatorcontrib><creatorcontrib>Souriau, Armel</creatorcontrib><creatorcontrib>Lamoureux, Bérénice</creatorcontrib><creatorcontrib>Ganneau, Christelle</creatorcontrib><creatorcontrib>Richard, Gaëlle</creatorcontrib><creatorcontrib>Cochard, Thierry</creatorcontrib><creatorcontrib>Tholoniat, Christophe</creatorcontrib><creatorcontrib>Bay, Sylvie</creatorcontrib><creatorcontrib>Winter, Nathalie</creatorcontrib><creatorcontrib>Moyen, Jean Louis</creatorcontrib><creatorcontrib>Biet, Franck</creatorcontrib><title>Interferon gamma response to Mycobacterium avium subsp. paratuberculosis specific lipopentapeptide antigen L5P in cattle</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>After Mycobacterium avium subsp. paratuberculosis (Map) infection the cell-mediated immune (CMI) response indicative of early Th1 activation may be detected using interferon-gamma release assay (IGRA). Currently, the purified protein derivatives (PPDs), i.e., the total extract of mycobacteria antigens are used to recall CMI responses against Map.
This study aimed to assess the ability of the chemically synthesized Map specific cell wall lipopentapeptide L5P to induce CMI response in cows infected by Map compared to PPD. L5P and PPD elicited an IFN-γ response in 12 and 35 animals from two Map infected herds respectively, but IFN-γ was not detected in the 13 cows recruited from a non-infected herd. Levels of IFN-γ detected were higher with PPD than with L5P. There was no correlation between the IFN-γ response and the humoral response to Map or faecal culture.
•Non-infected, Map infected and Mycobacterium bovis infected cattle herds recruited to explore whole blood CMI response•Chemically synthetized Map-specific antigen L5P tested in IGRA•L5P can induce CMI responses which can be quantified by assaying IFN-γ release in whole blood stimulation.</description><subject>Animals</subject><subject>Antigen</subject><subject>Antigens, Bacterial - immunology</subject><subject>Cattle</subject><subject>Cattle Diseases - immunology</subject><subject>Cattle Diseases - microbiology</subject><subject>Cell mediated immune response</subject><subject>Female</subject><subject>IFN-γ release assay: IGRA</subject><subject>Immunity, Cellular - immunology</subject><subject>Interferon-gamma - metabolism</subject><subject>Johne's disease</subject><subject>Life Sciences</subject><subject>Lipopentapeptide: L5P</subject><subject>Lipopeptide</subject><subject>Microbiology and Parasitology</subject><subject>Milk</subject><subject>Mycobacterium avium subsp. paratuberculosis</subject><subject>Mycobacterium avium subsp. paratuberculosis - immunology</subject><subject>Mycobacterium avium subsp. paratuberculosis - metabolism</subject><subject>Paratuberculosis</subject><subject>Paratuberculosis - immunology</subject><subject>Paratuberculosis - microbiology</subject><subject>Tuberculin</subject><subject>Tuberculosis</subject><subject>Veterinary medicine</subject><subject>Wildlife</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxSMEotvCF-CALHGhhwSP4z-JxKWqgFZaBAc4W44zKV4lsbGdFf32JNrSAwfEZUYa_eZp3ryieAW0Agry3aGKx2QrRkFUVFUU1JNiB6JmJZMSnhY7SmteCtY0Z8V5SgdKKQdQz4szJjkwUdNd8et2zhgHjH4md2aaDImYgp8TkuzJ53vrO2NXwi0TMcetpqVLoSLBRJOXDqNdRp9cIimgdYOzZHTBB5yzCRiy65GYObs7nMlefCVuJtbkPOKL4tlgxoQvH_pF8f3jh2_XN-X-y6fb66t9aXkrcgnIcTWAprMDNC3toe8NH4SUrWJctRQMDDVfpw2CFT3afuA1A1pbYZXE-qK4POn-MKMO0U0m3mtvnL652uttRgGapmbsCCv79sSG6H8umLKeXLI4jmZGvyQNSgADIdvmP1BQXNUN31Tf_IUe_BLn1fRGyVZKTsVKsRNlo08p4vB4LFC9xa0Peotbb3Frqta71br0-kF66SbsH1f-5LsC708Ari8-Oow6WYezxd5FtFn33v1L_zcW47wd</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Holbert, Sébastien</creator><creator>Branger, Maxime</creator><creator>Souriau, Armel</creator><creator>Lamoureux, Bérénice</creator><creator>Ganneau, Christelle</creator><creator>Richard, Gaëlle</creator><creator>Cochard, Thierry</creator><creator>Tholoniat, Christophe</creator><creator>Bay, Sylvie</creator><creator>Winter, Nathalie</creator><creator>Moyen, Jean Louis</creator><creator>Biet, Franck</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7QL</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-3985-1753</orcidid><orcidid>https://orcid.org/0000-0001-7655-3144</orcidid><orcidid>https://orcid.org/0000-0002-5614-9504</orcidid><orcidid>https://orcid.org/0000-0003-0994-7834</orcidid><orcidid>https://orcid.org/0000-0001-8425-6158</orcidid><orcidid>https://orcid.org/0000-0002-0982-5872</orcidid></search><sort><creationdate>20151001</creationdate><title>Interferon gamma response to Mycobacterium avium subsp. paratuberculosis specific lipopentapeptide antigen L5P in cattle</title><author>Holbert, Sébastien ; 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Currently, the purified protein derivatives (PPDs), i.e., the total extract of mycobacteria antigens are used to recall CMI responses against Map.
This study aimed to assess the ability of the chemically synthesized Map specific cell wall lipopentapeptide L5P to induce CMI response in cows infected by Map compared to PPD. L5P and PPD elicited an IFN-γ response in 12 and 35 animals from two Map infected herds respectively, but IFN-γ was not detected in the 13 cows recruited from a non-infected herd. Levels of IFN-γ detected were higher with PPD than with L5P. There was no correlation between the IFN-γ response and the humoral response to Map or faecal culture.
•Non-infected, Map infected and Mycobacterium bovis infected cattle herds recruited to explore whole blood CMI response•Chemically synthetized Map-specific antigen L5P tested in IGRA•L5P can induce CMI responses which can be quantified by assaying IFN-γ release in whole blood stimulation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26412530</pmid><doi>10.1016/j.rvsc.2015.07.017</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-3985-1753</orcidid><orcidid>https://orcid.org/0000-0001-7655-3144</orcidid><orcidid>https://orcid.org/0000-0002-5614-9504</orcidid><orcidid>https://orcid.org/0000-0003-0994-7834</orcidid><orcidid>https://orcid.org/0000-0001-8425-6158</orcidid><orcidid>https://orcid.org/0000-0002-0982-5872</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Research in veterinary science, 2015-10, Vol.102, p.118-121 |
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| subjects | Animals Antigen Antigens, Bacterial - immunology Cattle Cattle Diseases - immunology Cattle Diseases - microbiology Cell mediated immune response Female IFN-γ release assay: IGRA Immunity, Cellular - immunology Interferon-gamma - metabolism Johne's disease Life Sciences Lipopentapeptide: L5P Lipopeptide Microbiology and Parasitology Milk Mycobacterium avium subsp. paratuberculosis Mycobacterium avium subsp. paratuberculosis - immunology Mycobacterium avium subsp. paratuberculosis - metabolism Paratuberculosis Paratuberculosis - immunology Paratuberculosis - microbiology Tuberculin Tuberculosis Veterinary medicine Wildlife |
| title | Interferon gamma response to Mycobacterium avium subsp. paratuberculosis specific lipopentapeptide antigen L5P in cattle |
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