The Position of Rumenic Acid on Triacylglycerols Alters Its Bioavailability in Rats
The metabolic fate of rumenic acid (9cis,11trans-octadecenoic acid) related to its position on the glycerol moiety has not yet been studied. In the present work, synthetic triacylglycerols (TAG) esterified with oleic and rumenic acids were prepared. Rats were force-fed synthetic dioleyl monorumenyl...
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| Veröffentlicht in: | The Journal of nutrition 2003-12, Vol.133 (12), p.4212-4214 |
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| creator | Chardigny, J.M. Masson, E. Sergiel, J.P. Darbois, M. Sébédio, J.-L. Loreau, O. Noël, J.P. |
| description | The metabolic fate of rumenic acid (9cis,11trans-octadecenoic acid) related to its position on the glycerol moiety has not yet been studied. In the present work, synthetic triacylglycerols (TAG) esterified with oleic and rumenic acids were prepared. Rats were force-fed synthetic dioleyl monorumenyl glycerol with 14C labeled rumenic acid in the internal (sn-2) or in the external position (sn-1 or sn-3). Rats were then placed in metabolic cages for 16 h. At the end of the experiment, the radioactivity in tissues, carcass and expired CO2 was measured. Rumenic acid that was esterified at the external positions on the TAG was better absorbed and oxidized to a greater extent than when esterified at the internal position. The fatty acid from the 2-TAG form was also better incorporated into the rat carcass. In the liver, rumenic acid appeared mainly in TAG (50%) and to a lesser extent in phospholipids (33%) whatever its dietary form. Moreover, analyses of lipids from “Camembert” cheese and butter revealed that rumenic acid was located mainly on the sn-1 or sn-3 positions (74%). Taken together, these data suggest that rumenic acid from dairy fat may be well absorbed and used extensively for energy production. |
| doi_str_mv | 10.1093/jn/133.12.4212 |
| format | Article |
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In the present work, synthetic triacylglycerols (TAG) esterified with oleic and rumenic acids were prepared. Rats were force-fed synthetic dioleyl monorumenyl glycerol with 14C labeled rumenic acid in the internal (sn-2) or in the external position (sn-1 or sn-3). Rats were then placed in metabolic cages for 16 h. At the end of the experiment, the radioactivity in tissues, carcass and expired CO2 was measured. Rumenic acid that was esterified at the external positions on the TAG was better absorbed and oxidized to a greater extent than when esterified at the internal position. The fatty acid from the 2-TAG form was also better incorporated into the rat carcass. In the liver, rumenic acid appeared mainly in TAG (50%) and to a lesser extent in phospholipids (33%) whatever its dietary form. Moreover, analyses of lipids from “Camembert” cheese and butter revealed that rumenic acid was located mainly on the sn-1 or sn-3 positions (74%). Taken together, these data suggest that rumenic acid from dairy fat may be well absorbed and used extensively for energy production.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/133.12.4212</identifier><identifier>PMID: 14652374</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Animals ; bioavailability ; Biological and medical sciences ; Biological Availability ; Butter ; Cheese ; dairy fat ; Esterification ; Feeding. Feeding behavior ; Food and Nutrition ; Fundamental and applied biological sciences. Psychology ; Life Sciences ; Linoleic Acids, Conjugated - chemistry ; Linoleic Acids, Conjugated - metabolism ; Linoleic Acids, Conjugated - pharmacokinetics ; Lipids - chemistry ; Liver - metabolism ; Male ; Molecular Structure ; Oxidation-Reduction ; Phospholipids - chemistry ; Phospholipids - metabolism ; Rats ; Rats, Wistar ; rumenic acid ; triacylglycerols ; Triglycerides - chemistry ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The Journal of nutrition, 2003-12, Vol.133 (12), p.4212-4214</ispartof><rights>2003 American Society for Nutrition.</rights><rights>2004 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-915f449f1f0bd3bd02564fc68220f5eea0a9b4df2382bf36aa18dda50cdd702d3</citedby><cites>FETCH-LOGICAL-c510t-915f449f1f0bd3bd02564fc68220f5eea0a9b4df2382bf36aa18dda50cdd702d3</cites><orcidid>0000-0001-6312-0913</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15333969$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14652374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01187041$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Chardigny, J.M.</creatorcontrib><creatorcontrib>Masson, E.</creatorcontrib><creatorcontrib>Sergiel, J.P.</creatorcontrib><creatorcontrib>Darbois, M.</creatorcontrib><creatorcontrib>Sébédio, J.-L.</creatorcontrib><creatorcontrib>Loreau, O.</creatorcontrib><creatorcontrib>Noël, J.P.</creatorcontrib><title>The Position of Rumenic Acid on Triacylglycerols Alters Its Bioavailability in Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The metabolic fate of rumenic acid (9cis,11trans-octadecenoic acid) related to its position on the glycerol moiety has not yet been studied. In the present work, synthetic triacylglycerols (TAG) esterified with oleic and rumenic acids were prepared. Rats were force-fed synthetic dioleyl monorumenyl glycerol with 14C labeled rumenic acid in the internal (sn-2) or in the external position (sn-1 or sn-3). Rats were then placed in metabolic cages for 16 h. At the end of the experiment, the radioactivity in tissues, carcass and expired CO2 was measured. Rumenic acid that was esterified at the external positions on the TAG was better absorbed and oxidized to a greater extent than when esterified at the internal position. The fatty acid from the 2-TAG form was also better incorporated into the rat carcass. In the liver, rumenic acid appeared mainly in TAG (50%) and to a lesser extent in phospholipids (33%) whatever its dietary form. Moreover, analyses of lipids from “Camembert” cheese and butter revealed that rumenic acid was located mainly on the sn-1 or sn-3 positions (74%). Taken together, these data suggest that rumenic acid from dairy fat may be well absorbed and used extensively for energy production.</description><subject>Animals</subject><subject>bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Butter</subject><subject>Cheese</subject><subject>dairy fat</subject><subject>Esterification</subject><subject>Feeding. Feeding behavior</subject><subject>Food and Nutrition</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Life Sciences</subject><subject>Linoleic Acids, Conjugated - chemistry</subject><subject>Linoleic Acids, Conjugated - metabolism</subject><subject>Linoleic Acids, Conjugated - pharmacokinetics</subject><subject>Lipids - chemistry</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Molecular Structure</subject><subject>Oxidation-Reduction</subject><subject>Phospholipids - chemistry</subject><subject>Phospholipids - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>rumenic acid</subject><subject>triacylglycerols</subject><subject>Triglycerides - chemistry</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1rGzEQBmBRWhon7bXHoksLPawzI2nXu0cntEnA0JK6Z6HVRzNGXqXS2uB_3zU2zamngeGZl-Fl7APCHKGT15vhGqWco5grgeIVm2GtsGoQ4DWbAQhRSWyaC3ZZygYAUHXtW3aBqqmFXKgZ-7l-8vxHKjRSGngK_HG39QNZvrTk-LRaZzL2EH_Hg_U5xcKXcfS58Iex8BtKZm8omp4ijQdOA380Y3nH3gQTi39_nlfs17ev69v7avX97uF2uapsjTBWHdZBqS5ggN7J3oGoGxVs0woBofbegOl65YKQreiDbIzB1jlTg3VuAcLJK_bllPtkon7OtDX5oJMhfb9c6eMOENsFKNzjZD-f7HNOf3a-jHpLxfoYzeDTrugFKtHJRk5wfoI2p1KyD_-SEfSxcr0Z9FS5RqGPlU8HH8_Ju37r3Qs_dzyBT2dgijUxZDNYKi-ullJ2TTe59uT81NmefNbFkh-sd5S9HbVL9L8f_gLdMJsi</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Chardigny, J.M.</creator><creator>Masson, E.</creator><creator>Sergiel, J.P.</creator><creator>Darbois, M.</creator><creator>Sébédio, J.-L.</creator><creator>Loreau, O.</creator><creator>Noël, J.P.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><general>American Society for Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-6312-0913</orcidid></search><sort><creationdate>20031201</creationdate><title>The Position of Rumenic Acid on Triacylglycerols Alters Its Bioavailability in Rats</title><author>Chardigny, J.M. ; Masson, E. ; Sergiel, J.P. ; Darbois, M. ; Sébédio, J.-L. ; Loreau, O. ; Noël, J.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-915f449f1f0bd3bd02564fc68220f5eea0a9b4df2382bf36aa18dda50cdd702d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Butter</topic><topic>Cheese</topic><topic>dairy fat</topic><topic>Esterification</topic><topic>Feeding. Feeding behavior</topic><topic>Food and Nutrition</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Life Sciences</topic><topic>Linoleic Acids, Conjugated - chemistry</topic><topic>Linoleic Acids, Conjugated - metabolism</topic><topic>Linoleic Acids, Conjugated - pharmacokinetics</topic><topic>Lipids - chemistry</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Molecular Structure</topic><topic>Oxidation-Reduction</topic><topic>Phospholipids - chemistry</topic><topic>Phospholipids - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>rumenic acid</topic><topic>triacylglycerols</topic><topic>Triglycerides - chemistry</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chardigny, J.M.</creatorcontrib><creatorcontrib>Masson, E.</creatorcontrib><creatorcontrib>Sergiel, J.P.</creatorcontrib><creatorcontrib>Darbois, M.</creatorcontrib><creatorcontrib>Sébédio, J.-L.</creatorcontrib><creatorcontrib>Loreau, O.</creatorcontrib><creatorcontrib>Noël, J.P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chardigny, J.M.</au><au>Masson, E.</au><au>Sergiel, J.P.</au><au>Darbois, M.</au><au>Sébédio, J.-L.</au><au>Loreau, O.</au><au>Noël, J.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Position of Rumenic Acid on Triacylglycerols Alters Its Bioavailability in Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>133</volume><issue>12</issue><spage>4212</spage><epage>4214</epage><pages>4212-4214</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>The metabolic fate of rumenic acid (9cis,11trans-octadecenoic acid) related to its position on the glycerol moiety has not yet been studied. In the present work, synthetic triacylglycerols (TAG) esterified with oleic and rumenic acids were prepared. Rats were force-fed synthetic dioleyl monorumenyl glycerol with 14C labeled rumenic acid in the internal (sn-2) or in the external position (sn-1 or sn-3). Rats were then placed in metabolic cages for 16 h. At the end of the experiment, the radioactivity in tissues, carcass and expired CO2 was measured. Rumenic acid that was esterified at the external positions on the TAG was better absorbed and oxidized to a greater extent than when esterified at the internal position. The fatty acid from the 2-TAG form was also better incorporated into the rat carcass. In the liver, rumenic acid appeared mainly in TAG (50%) and to a lesser extent in phospholipids (33%) whatever its dietary form. Moreover, analyses of lipids from “Camembert” cheese and butter revealed that rumenic acid was located mainly on the sn-1 or sn-3 positions (74%). Taken together, these data suggest that rumenic acid from dairy fat may be well absorbed and used extensively for energy production.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>14652374</pmid><doi>10.1093/jn/133.12.4212</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0001-6312-0913</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals bioavailability Biological and medical sciences Biological Availability Butter Cheese dairy fat Esterification Feeding. Feeding behavior Food and Nutrition Fundamental and applied biological sciences. Psychology Life Sciences Linoleic Acids, Conjugated - chemistry Linoleic Acids, Conjugated - metabolism Linoleic Acids, Conjugated - pharmacokinetics Lipids - chemistry Liver - metabolism Male Molecular Structure Oxidation-Reduction Phospholipids - chemistry Phospholipids - metabolism Rats Rats, Wistar rumenic acid triacylglycerols Triglycerides - chemistry Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | The Position of Rumenic Acid on Triacylglycerols Alters Its Bioavailability in Rats |
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