Concerted Protonation of Key Histidines Triggers Membrane Interaction of the Diphtheria Toxin T Domain

The translocation domain (T domain) of the diphtheria toxin contributes to the transfer of the catalytic domain from the cell endosome to the cytosol, where it blocks protein synthesis. Translocation is initiated when endosome acidification induces the interaction of the T domain with the membrane o...

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Veröffentlicht in:	The Journal of biological chemistry 2007-08, Vol.282 (33), p.24239-24245
Hauptverfasser:	Perier, Aurélie, Chassaing, Anne, Raffestin, Stéphanie, Pichard, Sylvain, Masella, Michel, Ménez, André, Forge, Vincent, Chenal, Alexandre, Gillet, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Biochemistry, Molecular Biology Cellular Biology Cytosol - metabolism Diphtheria Toxin - chemistry Diphtheria Toxin - metabolism Endocytosis Endosomes - metabolism Histidine - chemistry Intracellular Membranes - metabolism Life Sciences Microbiology and Parasitology Protein Structure, Tertiary Protein Transport Protons
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