Biomimetic apatite-based composite materials obtained by spark plasma sintering (SPS): physicochemical and mechanical characterizations
Nanocrystalline calcium phosphate apatites are biomimetic compounds analogous to bone mineral and are at the origin of the bioactivity of most biomaterials used as bone substitutes. Their unique surface reactivity originates from the presence of a hydrated layer containing labile ions (mostly divale...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2015-08, Vol.26 (8), p.223-11, Article 223 |
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| creator | Brouillet, Fabien Laurencin, Danielle Grossin, David Drouet, Christophe Estournes, Claude Chevallier, Geoffroy Rey, Christian |
| description | Nanocrystalline calcium phosphate apatites are biomimetic compounds analogous to bone mineral and are at the origin of the bioactivity of most biomaterials used as bone substitutes. Their unique surface reactivity originates from the presence of a hydrated layer containing labile ions (mostly divalent ones). So the setup of 3D biocompatible apatite-based bioceramics exhibiting a high reactivity requests the development of «low» temperature consolidation processes such as spark plasma sintering (SPS), in order to preserve the characteristics of the hydrated nanocrystals. However, mechanical performances may still need to be improved for such nanocrystalline apatite bioceramics, especially in view of load-bearing applications. The reinforcement by association with biopolymers represents an appealing approach, while preserving the advantageous biological properties of biomimetic apatites. Herein, we report the preparation of composites based on biomimetic apatite associated with various quantities of microcrystalline cellulose (MCC, 1–20 wt%), a natural fibrous polymer. The SPS-consolidated composites were analyzed from both physicochemical (X-ray diffraction, Fourier transform infrared, solid state NMR) and mechanical (Brazilian test) viewpoints. The preservation of the physicochemical characteristics of apatite and cellulose in the final material was observed. Mechanical properties of the composite materials were found to be directly related to the polymer/apatite ratios and a maximum crushing strength was reached for 10 wt% of MCC.
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| doi_str_mv | 10.1007/s10856-015-5553-9 |
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Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Nanocrystalline calcium phosphate apatites are biomimetic compounds analogous to bone mineral and are at the origin of the bioactivity of most biomaterials used as bone substitutes. Their unique surface reactivity originates from the presence of a hydrated layer containing labile ions (mostly divalent ones). So the setup of 3D biocompatible apatite-based bioceramics exhibiting a high reactivity requests the development of «low» temperature consolidation processes such as spark plasma sintering (SPS), in order to preserve the characteristics of the hydrated nanocrystals. However, mechanical performances may still need to be improved for such nanocrystalline apatite bioceramics, especially in view of load-bearing applications. The reinforcement by association with biopolymers represents an appealing approach, while preserving the advantageous biological properties of biomimetic apatites. Herein, we report the preparation of composites based on biomimetic apatite associated with various quantities of microcrystalline cellulose (MCC, 1–20 wt%), a natural fibrous polymer. The SPS-consolidated composites were analyzed from both physicochemical (X-ray diffraction, Fourier transform infrared, solid state NMR) and mechanical (Brazilian test) viewpoints. The preservation of the physicochemical characteristics of apatite and cellulose in the final material was observed. Mechanical properties of the composite materials were found to be directly related to the polymer/apatite ratios and a maximum crushing strength was reached for 10 wt% of MCC.
Graphical Abstract</description><subject>Apatite</subject><subject>Apatites - chemical synthesis</subject><subject>Apatites - chemistry</subject><subject>Bioceramics</subject><subject>Biomaterials</subject><subject>Biomaterials Synthesis and Characterization</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Biomimetic Materials - chemical synthesis</subject><subject>Biomimetic Materials - chemistry</subject><subject>Biomimetics</subject><subject>Bone Substitutes - chemical synthesis</subject><subject>Bone Substitutes - chemistry</subject><subject>Cellulose</subject><subject>Ceramics</subject><subject>Ceramics - chemical synthesis</subject><subject>Ceramics - chemistry</subject><subject>Chemical Sciences</subject><subject>Chemistry and Materials Science</subject><subject>Composite materials</subject><subject>Composites</subject><subject>Glass</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Material chemistry</subject><subject>Materials Science</subject><subject>Materials Testing</subject><subject>Mechanical properties</subject><subject>Microscopy, Electron, Scanning</subject><subject>Nanocomposites - chemistry</subject><subject>Nanocomposites - ultrastructure</subject><subject>Nanocrystals</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Natural Materials</subject><subject>Plasma Gases</subject><subject>Plasma sintering</subject><subject>Polymer matrix composites</subject><subject>Polymer Sciences</subject><subject>Powder Diffraction</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Spark plasma sintering</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Surface Properties</subject><subject>Surfaces and Interfaces</subject><subject>Thin Films</subject><issn>0957-4530</issn><issn>1573-4838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkkFvFSEQx4nR2NfqB_BiSLy0h1XYBRa81aZak5doUj2TgWV91GVZYZ_J8wv4tWXd2hgTo-EAA7-ZYWb-CD2h5DklpH2RKZFcVITyinPeVOoe2lDeNhWTjbyPNkTxtmK8IUfoOOcbQghTnD9ER7WoW1pTsUHfX_kYfHCztxgmmP3sKgPZddjGMMVcbBxgdsnDkHE0M_ixPJoDzhOkz3gaIAfA2Y8LM37Cp9fvr89e4ml3yN5Gu3PBWxgwjB0Ozu5g_GmWQwK7uHwrOeOYH6EHfcngHt_uJ-jj68sPF1fV9t2btxfn28pyyueKW8KNISA7p0wn6pq3pleuB-Ekk33rmGiolYQLzix0himpelUYR0RdWtacoLM17g4GPSUfIB10BK-vzrd6uSOUSsGY_EoLe7qyU4pf9i7POvhs3TDA6OI-aypJWVIo_m-0LX-qGRPyP1DCmjInIgr67A_0Ju7TWPpTKMqoqmnDCkVXyqaYc3L9XV2U6EUnetVJKY3rRSdaFZ-nt5H3JrjuzuOXMApQr0CelrG69Fvqv0b9AV3oyDE</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Brouillet, Fabien</creator><creator>Laurencin, Danielle</creator><creator>Grossin, David</creator><creator>Drouet, Christophe</creator><creator>Estournes, Claude</creator><creator>Chevallier, Geoffroy</creator><creator>Rey, Christian</creator><general>Springer US</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0W</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-8471-8719</orcidid><orcidid>https://orcid.org/0000-0002-7445-0528</orcidid><orcidid>https://orcid.org/0000-0002-4320-2919</orcidid></search><sort><creationdate>20150801</creationdate><title>Biomimetic apatite-based composite materials obtained by spark plasma sintering (SPS): physicochemical and mechanical characterizations</title><author>Brouillet, Fabien ; Laurencin, Danielle ; Grossin, David ; Drouet, Christophe ; Estournes, Claude ; Chevallier, Geoffroy ; Rey, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-5c05bb0a8de9bd62257bf9efa6e848f7e4631c805654cadb4989f97bfe0620073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Apatite</topic><topic>Apatites - 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brouillet, Fabien</au><au>Laurencin, Danielle</au><au>Grossin, David</au><au>Drouet, Christophe</au><au>Estournes, Claude</au><au>Chevallier, Geoffroy</au><au>Rey, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomimetic apatite-based composite materials obtained by spark plasma sintering (SPS): physicochemical and mechanical characterizations</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>26</volume><issue>8</issue><spage>223</spage><epage>11</epage><pages>223-11</pages><artnum>223</artnum><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Nanocrystalline calcium phosphate apatites are biomimetic compounds analogous to bone mineral and are at the origin of the bioactivity of most biomaterials used as bone substitutes. Their unique surface reactivity originates from the presence of a hydrated layer containing labile ions (mostly divalent ones). So the setup of 3D biocompatible apatite-based bioceramics exhibiting a high reactivity requests the development of «low» temperature consolidation processes such as spark plasma sintering (SPS), in order to preserve the characteristics of the hydrated nanocrystals. However, mechanical performances may still need to be improved for such nanocrystalline apatite bioceramics, especially in view of load-bearing applications. The reinforcement by association with biopolymers represents an appealing approach, while preserving the advantageous biological properties of biomimetic apatites. Herein, we report the preparation of composites based on biomimetic apatite associated with various quantities of microcrystalline cellulose (MCC, 1–20 wt%), a natural fibrous polymer. The SPS-consolidated composites were analyzed from both physicochemical (X-ray diffraction, Fourier transform infrared, solid state NMR) and mechanical (Brazilian test) viewpoints. The preservation of the physicochemical characteristics of apatite and cellulose in the final material was observed. Mechanical properties of the composite materials were found to be directly related to the polymer/apatite ratios and a maximum crushing strength was reached for 10 wt% of MCC.
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| subjects | Apatite Apatites - chemical synthesis Apatites - chemistry Bioceramics Biomaterials Biomaterials Synthesis and Characterization Biomechanical Phenomena Biomedical Engineering and Bioengineering Biomedical materials Biomimetic Materials - chemical synthesis Biomimetic Materials - chemistry Biomimetics Bone Substitutes - chemical synthesis Bone Substitutes - chemistry Cellulose Ceramics Ceramics - chemical synthesis Ceramics - chemistry Chemical Sciences Chemistry and Materials Science Composite materials Composites Glass Humans Magnetic Resonance Spectroscopy Material chemistry Materials Science Materials Testing Mechanical properties Microscopy, Electron, Scanning Nanocomposites - chemistry Nanocomposites - ultrastructure Nanocrystals Nanoparticles - chemistry Nanoparticles - ultrastructure Natural Materials Plasma Gases Plasma sintering Polymer matrix composites Polymer Sciences Powder Diffraction Regenerative Medicine/Tissue Engineering Spark plasma sintering Spectroscopy, Fourier Transform Infrared Surface Properties Surfaces and Interfaces Thin Films |
| title | Biomimetic apatite-based composite materials obtained by spark plasma sintering (SPS): physicochemical and mechanical characterizations |
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