The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells

The WW domain containing oxidoreductase (WWOX) has recently been shown to inhibit of the Wnt/β-catenin pathway by preventing the nuclear import of disheveled 2 (DVL2) in human breast cancer cells. Here, it is revealed that WWOX also interacts with the BCL9-2, a cofactor of the Wnt/β-catenin pathway,...

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Veröffentlicht in:	Molecular cancer research 2015-05, Vol.13 (5), p.902-912
Hauptverfasser:	El-Hage, Perla, Petitalot, Ambre, Monsoro-Burq, Anne-Hélène, Maczkowiak, Frédérique, Driouch, Keltouma, Formstecher, Etienne, Camonis, Jacques, Sabbah, Michèle, Bièche, Ivan, Lidereau, Rosette, Lallemand, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Line, Tumor DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female HEK293 Cells Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Life Sciences MCF-7 Cells Mice Oxidoreductases - genetics Oxidoreductases - metabolism Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism WW Domain-Containing Oxidoreductase Xenopus
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