Multiple spine boutons are formed after long-lasting LTP in the awake rat
The formation of multiple spine boutons (MSBs) has been associated with cognitive abilities including hippocampal-dependent associative learning and memory. Data obtained from cultured hippocampal slices suggest that the long-term maintenance of synaptic plasticity requires the formation of new syna...
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| Veröffentlicht in: | Brain Structure and Function 2014-01, Vol.219 (1), p.407-414 |
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| creator | Medvedev, N. I. Dallérac, G. Popov, V. I. Rodriguez Arellano, J. J. Davies, H. A. Kraev, I. V. Doyère, V. Stewart, M. G. |
| description | The formation of multiple spine boutons (MSBs) has been associated with cognitive abilities including hippocampal-dependent associative learning and memory. Data obtained from cultured hippocampal slices suggest that the long-term maintenance of synaptic plasticity requires the formation of new synaptic contacts on pre-existing synapses. This postulate however, has never been tested in the awake, freely moving animals. In the current study, we induced long-term potentiation (LTP) in the dentate gyrus (DG) of awake adult rats and performed 3-D reconstructions of electron micrographs from thin sections of both axonal boutons and dendritic spines, 24 h post-induction. The specificity of the observed changes was demonstrated by comparison with animals in which long-term depression (LTD) had been induced, or with animals in which LTP was blocked by an
N
-methyl-
d
-aspartate (NMDA) antagonist. Our data demonstrate that whilst the number of boutons remains unchanged, there is a marked increase in the number of synapses per bouton 24 h after the induction of LTP. Further, we demonstrate that this increase is specific to mushroom spines and not attributable to their division. The present investigation thus fills the gap existing between behavioural and in vitro studies on the role of MSB formation in synaptic plasticity and cognitive abilities. |
| doi_str_mv | 10.1007/s00429-012-0488-0 |
| format | Article |
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N
-methyl-
d
-aspartate (NMDA) antagonist. Our data demonstrate that whilst the number of boutons remains unchanged, there is a marked increase in the number of synapses per bouton 24 h after the induction of LTP. Further, we demonstrate that this increase is specific to mushroom spines and not attributable to their division. The present investigation thus fills the gap existing between behavioural and in vitro studies on the role of MSB formation in synaptic plasticity and cognitive abilities.</description><identifier>ISSN: 1863-2653</identifier><identifier>EISSN: 1863-2661</identifier><identifier>EISSN: 0340-2061</identifier><identifier>DOI: 10.1007/s00429-012-0488-0</identifier><identifier>PMID: 23224218</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animal cognition ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Biophysics ; Brain ; Cell Biology ; Cognitive Sciences ; Computer Simulation ; Dendritic Spines ; Dendritic Spines - physiology ; Dendritic Spines - ultrastructure ; Electric Stimulation ; Electrodes, Implanted ; Excitatory Amino Acid Antagonists ; Excitatory Amino Acid Antagonists - pharmacology ; Hippocampus ; Hippocampus - cytology ; Hippocampus - physiology ; Life Sciences ; Long-Term Potentiation ; Long-Term Potentiation - drug effects ; Long-Term Potentiation - physiology ; Long-Term Synaptic Depression ; Long-Term Synaptic Depression - drug effects ; Long-Term Synaptic Depression - physiology ; Male ; Mental depression ; Nerve Net ; Nerve Net - physiology ; Nerve Net - ultrastructure ; Neurobiology ; Neurology ; Neurons and Cognition ; Neurosciences ; Piperazines ; Piperazines - pharmacology ; Psychology and behavior ; Rats ; Rats, Sprague-Dawley ; Rodents ; Short Communication ; Synapses ; Synapses - physiology ; Synapses - ultrastructure ; Time Factors ; Wakefulness</subject><ispartof>Brain Structure and Function, 2014-01, Vol.219 (1), p.407-414</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-a919df66a375ddc4bf293fe14715aceca41d44dda65798f0637f60bed70606c83</citedby><cites>FETCH-LOGICAL-c472t-a919df66a375ddc4bf293fe14715aceca41d44dda65798f0637f60bed70606c83</cites><orcidid>0000-0002-3851-669X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00429-012-0488-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00429-012-0488-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23224218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01181226$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Medvedev, N. I.</creatorcontrib><creatorcontrib>Dallérac, G.</creatorcontrib><creatorcontrib>Popov, V. I.</creatorcontrib><creatorcontrib>Rodriguez Arellano, J. J.</creatorcontrib><creatorcontrib>Davies, H. A.</creatorcontrib><creatorcontrib>Kraev, I. V.</creatorcontrib><creatorcontrib>Doyère, V.</creatorcontrib><creatorcontrib>Stewart, M. G.</creatorcontrib><title>Multiple spine boutons are formed after long-lasting LTP in the awake rat</title><title>Brain Structure and Function</title><addtitle>Brain Struct Funct</addtitle><addtitle>Brain Struct Funct</addtitle><description>The formation of multiple spine boutons (MSBs) has been associated with cognitive abilities including hippocampal-dependent associative learning and memory. Data obtained from cultured hippocampal slices suggest that the long-term maintenance of synaptic plasticity requires the formation of new synaptic contacts on pre-existing synapses. This postulate however, has never been tested in the awake, freely moving animals. In the current study, we induced long-term potentiation (LTP) in the dentate gyrus (DG) of awake adult rats and performed 3-D reconstructions of electron micrographs from thin sections of both axonal boutons and dendritic spines, 24 h post-induction. The specificity of the observed changes was demonstrated by comparison with animals in which long-term depression (LTD) had been induced, or with animals in which LTP was blocked by an
N
-methyl-
d
-aspartate (NMDA) antagonist. Our data demonstrate that whilst the number of boutons remains unchanged, there is a marked increase in the number of synapses per bouton 24 h after the induction of LTP. Further, we demonstrate that this increase is specific to mushroom spines and not attributable to their division. The present investigation thus fills the gap existing between behavioural and in vitro studies on the role of MSB formation in synaptic plasticity and cognitive abilities.</description><subject>Animal cognition</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Cognitive Sciences</subject><subject>Computer Simulation</subject><subject>Dendritic Spines</subject><subject>Dendritic Spines - physiology</subject><subject>Dendritic Spines - ultrastructure</subject><subject>Electric Stimulation</subject><subject>Electrodes, Implanted</subject><subject>Excitatory Amino Acid Antagonists</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Hippocampus</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - physiology</subject><subject>Life Sciences</subject><subject>Long-Term Potentiation</subject><subject>Long-Term Potentiation - drug effects</subject><subject>Long-Term Potentiation - physiology</subject><subject>Long-Term Synaptic Depression</subject><subject>Long-Term Synaptic Depression - drug effects</subject><subject>Long-Term Synaptic Depression - physiology</subject><subject>Male</subject><subject>Mental depression</subject><subject>Nerve Net</subject><subject>Nerve Net - physiology</subject><subject>Nerve Net - ultrastructure</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurons and Cognition</subject><subject>Neurosciences</subject><subject>Piperazines</subject><subject>Piperazines - pharmacology</subject><subject>Psychology and behavior</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Short Communication</subject><subject>Synapses</subject><subject>Synapses - physiology</subject><subject>Synapses - ultrastructure</subject><subject>Time Factors</subject><subject>Wakefulness</subject><issn>1863-2653</issn><issn>1863-2661</issn><issn>0340-2061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1PxCAQhonR6PrxA7wYEi96qM5QSstxs1HXZI0e9EzYFtZqt6zQavz3sqlujIknCDzzzMBLyDHCBQLklwGAM5kAsgR4USSwRUZYiDRhQuD2Zp-le2Q_hBeATBYod8keSxnjDIsRub3rm65eNYaGVd0aOnd959pAtTfUOr80FdW2M542rl0kjQ5d3S7o7PGB1i3tng3VH_rVUK-7Q7JjdRPM0fd6QJ6urx4n02R2f3M7Gc-SkuesS7REWVkhdJpnVVXyuWUytQZ5jpkuTak5VpxXlRZZLgsLIs2tgLmpchAgyiI9IOeD91k3auXrpfafyulaTccztT4DxAIZE-8Y2bOBXXn31pvQqWUdStM0ujWuDwq5hOjlnEf09A_64nrfxpdEKk-F5IythThQpXcheGM3EyCodSZqyCQOwdQ6EwWx5uTb3M_jf24qfkKIABuAEK_ahfG_Wv9r_QJbp5Q4</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Medvedev, N. I.</creator><creator>Dallérac, G.</creator><creator>Popov, V. I.</creator><creator>Rodriguez Arellano, J. J.</creator><creator>Davies, H. A.</creator><creator>Kraev, I. V.</creator><creator>Doyère, V.</creator><creator>Stewart, M. 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I.</au><au>Dallérac, G.</au><au>Popov, V. I.</au><au>Rodriguez Arellano, J. J.</au><au>Davies, H. A.</au><au>Kraev, I. V.</au><au>Doyère, V.</au><au>Stewart, M. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple spine boutons are formed after long-lasting LTP in the awake rat</atitle><jtitle>Brain Structure and Function</jtitle><stitle>Brain Struct Funct</stitle><addtitle>Brain Struct Funct</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>219</volume><issue>1</issue><spage>407</spage><epage>414</epage><pages>407-414</pages><issn>1863-2653</issn><eissn>1863-2661</eissn><eissn>0340-2061</eissn><abstract>The formation of multiple spine boutons (MSBs) has been associated with cognitive abilities including hippocampal-dependent associative learning and memory. Data obtained from cultured hippocampal slices suggest that the long-term maintenance of synaptic plasticity requires the formation of new synaptic contacts on pre-existing synapses. This postulate however, has never been tested in the awake, freely moving animals. In the current study, we induced long-term potentiation (LTP) in the dentate gyrus (DG) of awake adult rats and performed 3-D reconstructions of electron micrographs from thin sections of both axonal boutons and dendritic spines, 24 h post-induction. The specificity of the observed changes was demonstrated by comparison with animals in which long-term depression (LTD) had been induced, or with animals in which LTP was blocked by an
N
-methyl-
d
-aspartate (NMDA) antagonist. Our data demonstrate that whilst the number of boutons remains unchanged, there is a marked increase in the number of synapses per bouton 24 h after the induction of LTP. Further, we demonstrate that this increase is specific to mushroom spines and not attributable to their division. The present investigation thus fills the gap existing between behavioural and in vitro studies on the role of MSB formation in synaptic plasticity and cognitive abilities.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23224218</pmid><doi>10.1007/s00429-012-0488-0</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3851-669X</orcidid></addata></record> |
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| ispartof | Brain Structure and Function, 2014-01, Vol.219 (1), p.407-414 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Animal cognition Animals Biomedical and Life Sciences Biomedicine Biophysics Brain Cell Biology Cognitive Sciences Computer Simulation Dendritic Spines Dendritic Spines - physiology Dendritic Spines - ultrastructure Electric Stimulation Electrodes, Implanted Excitatory Amino Acid Antagonists Excitatory Amino Acid Antagonists - pharmacology Hippocampus Hippocampus - cytology Hippocampus - physiology Life Sciences Long-Term Potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Long-Term Synaptic Depression Long-Term Synaptic Depression - drug effects Long-Term Synaptic Depression - physiology Male Mental depression Nerve Net Nerve Net - physiology Nerve Net - ultrastructure Neurobiology Neurology Neurons and Cognition Neurosciences Piperazines Piperazines - pharmacology Psychology and behavior Rats Rats, Sprague-Dawley Rodents Short Communication Synapses Synapses - physiology Synapses - ultrastructure Time Factors Wakefulness |
| title | Multiple spine boutons are formed after long-lasting LTP in the awake rat |
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