HLA‐G01:04∼UTR3 Recipient Correlates With Lower Survival and Higher Frequency of Chronic Rejection After Lung Transplantation
Lung transplantation (LTx) is a valid therapeutic option for selected patients with end‐stage lung disease. Soluble HLA‐G (sHLA‐G) has been associated with increased graft survival and decreased rejection episodes in solid organ transplantation. HLA‐G haplotypes named UTRs, defined by SNPs from both...
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| Veröffentlicht in: | American journal of transplantation 2015-09, Vol.15 (9), p.2413-2420 |
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| creator | Di Cristofaro, J. Reynaud‐Gaubert, M. Carlini, F. Roubertoux, P. Loundou, A. Basire, A. Frassati, C. Thomas, P. Gomez, C. Picard, C. |
| description | Lung transplantation (LTx) is a valid therapeutic option for selected patients with end‐stage lung disease. Soluble HLA‐G (sHLA‐G) has been associated with increased graft survival and decreased rejection episodes in solid organ transplantation. HLA‐G haplotypes named UTRs, defined by SNPs from both the 5′URR and 3′UTR, have been reported to reliably predict sHLA‐G level. The aim of this retrospective study was to determine the impact of HLA‐G alleles and UTR polymorphism from LTx recipients on anti‐HLA allo‐immunization risk, overall survival and chronic rejection (CLAD). HLA‐G SNPs were genotyped in 124 recipients who underwent LTx from 1996 to 2010 in Marseille, 123 healthy individuals and 26 cystic fibrosis patients not requiring LTx. sHLA‐G levels were measured for 38 LTx patients at D0, M3 and M12 and for 123 healthy donors. HLA‐G*01:06∼UTR2 was associated with a worse evolution of cystic fibrosis (p = 0.005) but not of long‐term survival post‐LTx. HLA‐G*01:04∼UTR3 haplotype was associated with lower levels of sHLA‐G at D0 and M3 (p = 0.03), impaired long‐term survival (p = 0.001), increased CLAD occurrence (p = 0.03) and the production of de novo donor‐specific antibodies (DSA) at M3 (p = 0.01). This study is the first to show the deleterious association of different HLA‐G alleles and UTRs in LTx.
Focusing on HLA‐G genotype and dosage in patients after lung tr ansplantation, this study finds that a specific HLA‐G genotype is correlated with a lower survival rate and a h igher frequency of chronic rejection. |
| doi_str_mv | 10.1111/ajt.13305 |
| format | Article |
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Focusing on HLA‐G genotype and dosage in patients after lung tr ansplantation, this study finds that a specific HLA‐G genotype is correlated with a lower survival rate and a h igher frequency of chronic rejection.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/ajt.13305</identifier><identifier>PMID: 25989360</identifier><language>eng</language><publisher>United States: Elsevier</publisher><subject>3' Untranslated Regions - genetics ; Adult ; Bronchiolitis obliterans (BOS) ; Chronic Disease ; Female ; Follow-Up Studies ; function/dysfunction ; genetics ; Graft Rejection - epidemiology ; Graft Survival - physiology ; Haplotypes - genetics ; HLA-G Antigens - genetics ; Humans ; immune regulation ; Immunology ; Life Sciences ; lung (allograft) ; Lung Diseases - mortality ; Lung Diseases - surgery ; Lung Transplantation - adverse effects ; Male ; Polymorphism, Single Nucleotide - genetics ; Postoperative Complications ; Prognosis ; rejection: antibody‐mediated (ABMR) ; Retrospective Studies ; Risk Factors ; Survival Rate</subject><ispartof>American journal of transplantation, 2015-09, Vol.15 (9), p.2413-2420</ispartof><rights>Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3095-39b7cafa4c19f3c0804572ed41bd61219d3e1c33963b3f633ef2b876e3a1032c3</citedby><cites>FETCH-LOGICAL-c3095-39b7cafa4c19f3c0804572ed41bd61219d3e1c33963b3f633ef2b876e3a1032c3</cites><orcidid>0000-0001-9426-3570 ; 0000-0001-9013-2725</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajt.13305$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajt.13305$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25989360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01172184$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Cristofaro, J.</creatorcontrib><creatorcontrib>Reynaud‐Gaubert, M.</creatorcontrib><creatorcontrib>Carlini, F.</creatorcontrib><creatorcontrib>Roubertoux, P.</creatorcontrib><creatorcontrib>Loundou, A.</creatorcontrib><creatorcontrib>Basire, A.</creatorcontrib><creatorcontrib>Frassati, C.</creatorcontrib><creatorcontrib>Thomas, P.</creatorcontrib><creatorcontrib>Gomez, C.</creatorcontrib><creatorcontrib>Picard, C.</creatorcontrib><title>HLA‐G01:04∼UTR3 Recipient Correlates With Lower Survival and Higher Frequency of Chronic Rejection After Lung Transplantation</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>Lung transplantation (LTx) is a valid therapeutic option for selected patients with end‐stage lung disease. Soluble HLA‐G (sHLA‐G) has been associated with increased graft survival and decreased rejection episodes in solid organ transplantation. HLA‐G haplotypes named UTRs, defined by SNPs from both the 5′URR and 3′UTR, have been reported to reliably predict sHLA‐G level. The aim of this retrospective study was to determine the impact of HLA‐G alleles and UTR polymorphism from LTx recipients on anti‐HLA allo‐immunization risk, overall survival and chronic rejection (CLAD). HLA‐G SNPs were genotyped in 124 recipients who underwent LTx from 1996 to 2010 in Marseille, 123 healthy individuals and 26 cystic fibrosis patients not requiring LTx. sHLA‐G levels were measured for 38 LTx patients at D0, M3 and M12 and for 123 healthy donors. HLA‐G*01:06∼UTR2 was associated with a worse evolution of cystic fibrosis (p = 0.005) but not of long‐term survival post‐LTx. HLA‐G*01:04∼UTR3 haplotype was associated with lower levels of sHLA‐G at D0 and M3 (p = 0.03), impaired long‐term survival (p = 0.001), increased CLAD occurrence (p = 0.03) and the production of de novo donor‐specific antibodies (DSA) at M3 (p = 0.01). This study is the first to show the deleterious association of different HLA‐G alleles and UTRs in LTx.
Focusing on HLA‐G genotype and dosage in patients after lung tr ansplantation, this study finds that a specific HLA‐G genotype is correlated with a lower survival rate and a h igher frequency of chronic rejection.</description><subject>3' Untranslated Regions - genetics</subject><subject>Adult</subject><subject>Bronchiolitis obliterans (BOS)</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>function/dysfunction</subject><subject>genetics</subject><subject>Graft Rejection - epidemiology</subject><subject>Graft Survival - physiology</subject><subject>Haplotypes - genetics</subject><subject>HLA-G Antigens - genetics</subject><subject>Humans</subject><subject>immune regulation</subject><subject>Immunology</subject><subject>Life Sciences</subject><subject>lung (allograft)</subject><subject>Lung Diseases - mortality</subject><subject>Lung Diseases - surgery</subject><subject>Lung Transplantation - adverse effects</subject><subject>Male</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Postoperative Complications</subject><subject>Prognosis</subject><subject>rejection: antibody‐mediated (ABMR)</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9uEzEQhy0EoqXlwAsgH-GQ1rOzf7mtorYBrVSppOrR8npnG0ebdbB3U-UGN448EE_TJ8EhbTjhi63xp08z82PsHYgzCOdcLYczQBTJC3YMqRCTFGJ8eXhjcsTeeL8UArIoj16zoygp8gJTccx-zKry8fuvKwGfRPz48_ft_Ab5DWmzNtQPfGqdo04N5PmdGRa8sg_k-NfRbcxGdVz1DZ-Z-0WoXTr6NlKvt9y2fLpwtjc6iJakB2N7XrZDgKqxv-dzp3q_7lQ_qN3XKXvVqs7T26f7hN1eXsyns0l1ffV5WlYTjaJIJljUmVatijUULWqRizjJImpiqJsUIigaJNCIRYo1tikitVGdZymhAoGRxhP2ce9dqE6unVkpt5VWGTkrK7mrCQjrgTzeQGA_7Nm1s2EqP8iV8Zq60DTZ0UvIRJJhlAn8p9XOeu-oPbhByF06MqQj_6YT2PdP2rFeUXMgn-MIwPkeeDAdbf9vkuWX-V75B_PomV8</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Di Cristofaro, J.</creator><creator>Reynaud‐Gaubert, M.</creator><creator>Carlini, F.</creator><creator>Roubertoux, P.</creator><creator>Loundou, A.</creator><creator>Basire, A.</creator><creator>Frassati, C.</creator><creator>Thomas, P.</creator><creator>Gomez, C.</creator><creator>Picard, C.</creator><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-9426-3570</orcidid><orcidid>https://orcid.org/0000-0001-9013-2725</orcidid></search><sort><creationdate>201509</creationdate><title>HLA‐G01:04∼UTR3 Recipient Correlates With Lower Survival and Higher Frequency of Chronic Rejection After Lung Transplantation</title><author>Di Cristofaro, J. ; Reynaud‐Gaubert, M. ; Carlini, F. ; Roubertoux, P. ; Loundou, A. ; Basire, A. ; Frassati, C. ; Thomas, P. ; Gomez, C. ; Picard, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3095-39b7cafa4c19f3c0804572ed41bd61219d3e1c33963b3f633ef2b876e3a1032c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>3' Untranslated Regions - genetics</topic><topic>Adult</topic><topic>Bronchiolitis obliterans (BOS)</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>function/dysfunction</topic><topic>genetics</topic><topic>Graft Rejection - epidemiology</topic><topic>Graft Survival - physiology</topic><topic>Haplotypes - genetics</topic><topic>HLA-G Antigens - genetics</topic><topic>Humans</topic><topic>immune regulation</topic><topic>Immunology</topic><topic>Life Sciences</topic><topic>lung (allograft)</topic><topic>Lung Diseases - mortality</topic><topic>Lung Diseases - surgery</topic><topic>Lung Transplantation - adverse effects</topic><topic>Male</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Postoperative Complications</topic><topic>Prognosis</topic><topic>rejection: antibody‐mediated (ABMR)</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Cristofaro, J.</creatorcontrib><creatorcontrib>Reynaud‐Gaubert, M.</creatorcontrib><creatorcontrib>Carlini, F.</creatorcontrib><creatorcontrib>Roubertoux, P.</creatorcontrib><creatorcontrib>Loundou, A.</creatorcontrib><creatorcontrib>Basire, A.</creatorcontrib><creatorcontrib>Frassati, C.</creatorcontrib><creatorcontrib>Thomas, P.</creatorcontrib><creatorcontrib>Gomez, C.</creatorcontrib><creatorcontrib>Picard, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Cristofaro, J.</au><au>Reynaud‐Gaubert, M.</au><au>Carlini, F.</au><au>Roubertoux, P.</au><au>Loundou, A.</au><au>Basire, A.</au><au>Frassati, C.</au><au>Thomas, P.</au><au>Gomez, C.</au><au>Picard, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA‐G01:04∼UTR3 Recipient Correlates With Lower Survival and Higher Frequency of Chronic Rejection After Lung Transplantation</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2015-09</date><risdate>2015</risdate><volume>15</volume><issue>9</issue><spage>2413</spage><epage>2420</epage><pages>2413-2420</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>Lung transplantation (LTx) is a valid therapeutic option for selected patients with end‐stage lung disease. Soluble HLA‐G (sHLA‐G) has been associated with increased graft survival and decreased rejection episodes in solid organ transplantation. HLA‐G haplotypes named UTRs, defined by SNPs from both the 5′URR and 3′UTR, have been reported to reliably predict sHLA‐G level. The aim of this retrospective study was to determine the impact of HLA‐G alleles and UTR polymorphism from LTx recipients on anti‐HLA allo‐immunization risk, overall survival and chronic rejection (CLAD). HLA‐G SNPs were genotyped in 124 recipients who underwent LTx from 1996 to 2010 in Marseille, 123 healthy individuals and 26 cystic fibrosis patients not requiring LTx. sHLA‐G levels were measured for 38 LTx patients at D0, M3 and M12 and for 123 healthy donors. HLA‐G*01:06∼UTR2 was associated with a worse evolution of cystic fibrosis (p = 0.005) but not of long‐term survival post‐LTx. HLA‐G*01:04∼UTR3 haplotype was associated with lower levels of sHLA‐G at D0 and M3 (p = 0.03), impaired long‐term survival (p = 0.001), increased CLAD occurrence (p = 0.03) and the production of de novo donor‐specific antibodies (DSA) at M3 (p = 0.01). This study is the first to show the deleterious association of different HLA‐G alleles and UTRs in LTx.
Focusing on HLA‐G genotype and dosage in patients after lung tr ansplantation, this study finds that a specific HLA‐G genotype is correlated with a lower survival rate and a h igher frequency of chronic rejection.</abstract><cop>United States</cop><pub>Elsevier</pub><pmid>25989360</pmid><doi>10.1111/ajt.13305</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9426-3570</orcidid><orcidid>https://orcid.org/0000-0001-9013-2725</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 3' Untranslated Regions - genetics Adult Bronchiolitis obliterans (BOS) Chronic Disease Female Follow-Up Studies function/dysfunction genetics Graft Rejection - epidemiology Graft Survival - physiology Haplotypes - genetics HLA-G Antigens - genetics Humans immune regulation Immunology Life Sciences lung (allograft) Lung Diseases - mortality Lung Diseases - surgery Lung Transplantation - adverse effects Male Polymorphism, Single Nucleotide - genetics Postoperative Complications Prognosis rejection: antibody‐mediated (ABMR) Retrospective Studies Risk Factors Survival Rate |
| title | HLA‐G01:04∼UTR3 Recipient Correlates With Lower Survival and Higher Frequency of Chronic Rejection After Lung Transplantation |
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