The antitumor effects of an arsthinol–cyclodextrin complex in a heterotopic mouse model of glioma

[Display omitted] In this paper, we examined arsthinol–cyclodextrin complexes, which display an anticancer activity. The association constants were 17,502±522M−1 for hydroxypropyl-β-cyclodextrin and 12,038±10,168M−1 for randomized methylated β-cyclodextrin. 1H NMR experiments in solution also confir...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2013-11, Vol.85 (3), p.560-568
Hauptverfasser:	Becherirat, Selma, Lanhers, Marie-Claire, Socha, Marie, Yemloul, Mehdi, Astier, Alain, Loboda, Caroline, Aniceto, Natália, Gibaud, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Arsenic Arsenicals - administration & dosage Arsenicals - chemistry Arsenicals - pharmacology beta-Cyclodextrins - chemistry Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain tumors Cancer Cell Line, Tumor Cyclodextrin Excipients - chemistry Female Glioblastoma Glioma Glioma - drug therapy Glioma - pathology Humans Injections, Intraperitoneal Life Sciences Magnetic Resonance Spectroscopy Melarsoprol - administration & dosage Melarsoprol - chemistry Melarsoprol - pharmacology Mice Mice, Nude Oxides - administration & dosage Oxides - chemistry Oxides - pharmacology Pharmaceutical sciences Xenograft Model Antitumor Assays
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