Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid arthritis
Objectives To evaluate different global ultrasonographic (US) synovitis scoring systems as potential outcome measures of rheumatoid arthritis (RA) according to the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) filter. Methods To study selected global scoring systems, for the cli...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2010-05, Vol.69 (5), p.828-833 |
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| creator | Dougados, Maxime Jousse-Joulin, Sandrine Mistretta, Frederic d'Agostino, Maria-Antonietta Backhaus, Marina Bentin, Jacques Chalès, Gérard Chary-Valckenaere, Isabelle Conaghan, Philip Etchepare, Fabien Gaudin, Philippe Grassi, Walter van der Heijde, Désirée Sellam, Jérémie Naredo, Esperanza Szkudlarek, Marcin Wakefield, Richard Saraux, Alain |
| description | Objectives To evaluate different global ultrasonographic (US) synovitis scoring systems as potential outcome measures of rheumatoid arthritis (RA) according to the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) filter. Methods To study selected global scoring systems, for the clinical, B mode and power Doppler techniques, the following joints were evaluated: 28 joints (28-joint Disease Activity Score (DAS28)), 20 joints (metacarpophalangeals (MCPs) + metatarsophalangeals (MTPs)) and 38 joints (28 joints + MTPs) using either a binary (yes/no) or a 0–3 grade. The study was a prospective, 4-month duration follow-up of 76 patients with RA requiring anti-tumour necrosis factor (TNF) therapy (complete follow-up data: 66 patients). Intraobserver reliability was evaluated using the intraclass correlation coefficient (ICC), construct validity was evaluated using the Cronbach α test and external validity was evaluated using level of correlation between scoring system and C reactive protein (CRP). Sensitivity to change was evaluated using the standardised response mean. Discriminating capacity was evaluated using the standardised mean differences in patients considered by the doctor as significantly improved or not at the end of the study. Results Different clinimetric properties of various US scoring systems were at least as good as the clinical scores with, for example, intraobserver reliability ranging from 0.61 to 0.97 versus from 0.53 to 0.82, construct validity ranging from 0.76 to 0.89 versus from 0.76 to 0.88, correlation with CRP ranging from 0.28 to 0.34 versus from 0.28 to 0.35 and sensitivity to change ranging from 0.60 to 1.21 versus from 0.96 to 1.36 for US versus clinical scoring systems, respectively. Conclusion This study suggests that US evaluation of synovitis is an outcome measure at least as relevant as physical examination. Further studies are required in order to achieve optimal US scoring systems for monitoring patients with RA in clinical trials and in clinical practice. |
| doi_str_mv | 10.1136/ard.2009.115493 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01150426v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733334822</sourcerecordid><originalsourceid>FETCH-LOGICAL-b461t-9ea9889cf8dac3b8c672906da2fbddff967881a95ba454f5cc76092c6284cc293</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhiMEotvCmRuyhBACKa3tJP7gVq1airR8CEEPXKyJ43S9JPFiO6vuv-In4pDVInHBF3vsZ94Zz5tlzwg-J6RgF-Cbc4qxTFFVyuJBtiAlEznFDD_MFhjjIi8l4yfZaQibFGJBxOPshEheYomrRfbragfdCNG6AbkWBbMzHjo0dtFDcIO787Bd71HQztvhDoV9iKYPqHU-nQe3s9EGBEODtOu34G3KQdEh3dnB6iRk7qG3wx_9t8ibkIRTtnc9ArT1LmyNjnZnUJ8erDZD9AaFODb7qRu_NmMP0dkGgY9rPxV7kj1qoQvm6WE_y75dX31d3uSrT-_eLy9XeV0yEnNpQAohdSsa0EUtNONUYtYAbeumads0FCEIyKqGsirbSmvOsKSaUVFqTWVxlr2eddfQqa23Pfi9cmDVzeVKTXc4jRyXlO1IYl_NbPrRz9GEqHobtOk6GIwbg-JFWqWgNJEv_iE3bvRD-oginHPBMBFT7YuZ0mlCwZv22ADBavJdJd_V5LuafU8Zzw-6Y92b5i9_MDoBLw8AhORL62HQNhw5SllZUD6VzmfOJqPvj-_gfyjGC16pj7dLdfthSST-_EV9T_ybma_7zX-7_A2fCNbv</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1777860189</pqid></control><display><type>article</type><title>Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid arthritis</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Dougados, Maxime ; Jousse-Joulin, Sandrine ; Mistretta, Frederic ; d'Agostino, Maria-Antonietta ; Backhaus, Marina ; Bentin, Jacques ; Chalès, Gérard ; Chary-Valckenaere, Isabelle ; Conaghan, Philip ; Etchepare, Fabien ; Gaudin, Philippe ; Grassi, Walter ; van der Heijde, Désirée ; Sellam, Jérémie ; Naredo, Esperanza ; Szkudlarek, Marcin ; Wakefield, Richard ; Saraux, Alain</creator><creatorcontrib>Dougados, Maxime ; Jousse-Joulin, Sandrine ; Mistretta, Frederic ; d'Agostino, Maria-Antonietta ; Backhaus, Marina ; Bentin, Jacques ; Chalès, Gérard ; Chary-Valckenaere, Isabelle ; Conaghan, Philip ; Etchepare, Fabien ; Gaudin, Philippe ; Grassi, Walter ; van der Heijde, Désirée ; Sellam, Jérémie ; Naredo, Esperanza ; Szkudlarek, Marcin ; Wakefield, Richard ; Saraux, Alain</creatorcontrib><description>Objectives To evaluate different global ultrasonographic (US) synovitis scoring systems as potential outcome measures of rheumatoid arthritis (RA) according to the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) filter. Methods To study selected global scoring systems, for the clinical, B mode and power Doppler techniques, the following joints were evaluated: 28 joints (28-joint Disease Activity Score (DAS28)), 20 joints (metacarpophalangeals (MCPs) + metatarsophalangeals (MTPs)) and 38 joints (28 joints + MTPs) using either a binary (yes/no) or a 0–3 grade. The study was a prospective, 4-month duration follow-up of 76 patients with RA requiring anti-tumour necrosis factor (TNF) therapy (complete follow-up data: 66 patients). Intraobserver reliability was evaluated using the intraclass correlation coefficient (ICC), construct validity was evaluated using the Cronbach α test and external validity was evaluated using level of correlation between scoring system and C reactive protein (CRP). Sensitivity to change was evaluated using the standardised response mean. Discriminating capacity was evaluated using the standardised mean differences in patients considered by the doctor as significantly improved or not at the end of the study. Results Different clinimetric properties of various US scoring systems were at least as good as the clinical scores with, for example, intraobserver reliability ranging from 0.61 to 0.97 versus from 0.53 to 0.82, construct validity ranging from 0.76 to 0.89 versus from 0.76 to 0.88, correlation with CRP ranging from 0.28 to 0.34 versus from 0.28 to 0.35 and sensitivity to change ranging from 0.60 to 1.21 versus from 0.96 to 1.36 for US versus clinical scoring systems, respectively. Conclusion This study suggests that US evaluation of synovitis is an outcome measure at least as relevant as physical examination. Further studies are required in order to achieve optimal US scoring systems for monitoring patients with RA in clinical trials and in clinical practice.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.2009.115493</identifier><identifier>PMID: 19740905</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Adult ; Aged ; Antirheumatic Agents - therapeutic use ; Arthritis, Rheumatoid - diagnostic imaging ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - pathology ; Biological and medical sciences ; Clinical trials ; Diseases of the osteoarticular system ; Epidemiologic Methods ; Female ; Humans ; Hypotheses ; Immunology ; Inflammatory joint diseases ; Life Sciences ; Male ; Medical sciences ; Middle Aged ; Observer Variation ; Patients ; Physical Examination - methods ; Studies ; Synovitis - diagnostic imaging ; Synovitis - drug therapy ; Synovitis - pathology ; TNF inhibitors ; Treatment Outcome ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Tumor necrosis factor-TNF ; Ultrasonography, Doppler - methods ; Validity</subject><ispartof>Annals of the rheumatic diseases, 2010-05, Vol.69 (5), p.828-833</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2010 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b461t-9ea9889cf8dac3b8c672906da2fbddff967881a95ba454f5cc76092c6284cc293</citedby><cites>FETCH-LOGICAL-b461t-9ea9889cf8dac3b8c672906da2fbddff967881a95ba454f5cc76092c6284cc293</cites><orcidid>0000-0002-5479-5887 ; 0000-0003-3386-6276 ; 0000-0002-5781-158X ; 0000-0002-8454-7067 ; 0000-0002-1814-6003</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/69/5/828.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/69/5/828.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,776,780,881,3183,23550,27901,27902,77569,77600</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22643279$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19740905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01150426$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Dougados, Maxime</creatorcontrib><creatorcontrib>Jousse-Joulin, Sandrine</creatorcontrib><creatorcontrib>Mistretta, Frederic</creatorcontrib><creatorcontrib>d'Agostino, Maria-Antonietta</creatorcontrib><creatorcontrib>Backhaus, Marina</creatorcontrib><creatorcontrib>Bentin, Jacques</creatorcontrib><creatorcontrib>Chalès, Gérard</creatorcontrib><creatorcontrib>Chary-Valckenaere, Isabelle</creatorcontrib><creatorcontrib>Conaghan, Philip</creatorcontrib><creatorcontrib>Etchepare, Fabien</creatorcontrib><creatorcontrib>Gaudin, Philippe</creatorcontrib><creatorcontrib>Grassi, Walter</creatorcontrib><creatorcontrib>van der Heijde, Désirée</creatorcontrib><creatorcontrib>Sellam, Jérémie</creatorcontrib><creatorcontrib>Naredo, Esperanza</creatorcontrib><creatorcontrib>Szkudlarek, Marcin</creatorcontrib><creatorcontrib>Wakefield, Richard</creatorcontrib><creatorcontrib>Saraux, Alain</creatorcontrib><title>Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid arthritis</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Objectives To evaluate different global ultrasonographic (US) synovitis scoring systems as potential outcome measures of rheumatoid arthritis (RA) according to the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) filter. Methods To study selected global scoring systems, for the clinical, B mode and power Doppler techniques, the following joints were evaluated: 28 joints (28-joint Disease Activity Score (DAS28)), 20 joints (metacarpophalangeals (MCPs) + metatarsophalangeals (MTPs)) and 38 joints (28 joints + MTPs) using either a binary (yes/no) or a 0–3 grade. The study was a prospective, 4-month duration follow-up of 76 patients with RA requiring anti-tumour necrosis factor (TNF) therapy (complete follow-up data: 66 patients). Intraobserver reliability was evaluated using the intraclass correlation coefficient (ICC), construct validity was evaluated using the Cronbach α test and external validity was evaluated using level of correlation between scoring system and C reactive protein (CRP). Sensitivity to change was evaluated using the standardised response mean. Discriminating capacity was evaluated using the standardised mean differences in patients considered by the doctor as significantly improved or not at the end of the study. Results Different clinimetric properties of various US scoring systems were at least as good as the clinical scores with, for example, intraobserver reliability ranging from 0.61 to 0.97 versus from 0.53 to 0.82, construct validity ranging from 0.76 to 0.89 versus from 0.76 to 0.88, correlation with CRP ranging from 0.28 to 0.34 versus from 0.28 to 0.35 and sensitivity to change ranging from 0.60 to 1.21 versus from 0.96 to 1.36 for US versus clinical scoring systems, respectively. Conclusion This study suggests that US evaluation of synovitis is an outcome measure at least as relevant as physical examination. Further studies are required in order to achieve optimal US scoring systems for monitoring patients with RA in clinical trials and in clinical practice.</description><subject>Adult</subject><subject>Aged</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis, Rheumatoid - diagnostic imaging</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Biological and medical sciences</subject><subject>Clinical trials</subject><subject>Diseases of the osteoarticular system</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Immunology</subject><subject>Inflammatory joint diseases</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>Patients</subject><subject>Physical Examination - methods</subject><subject>Studies</subject><subject>Synovitis - diagnostic imaging</subject><subject>Synovitis - drug therapy</subject><subject>Synovitis - pathology</subject><subject>TNF inhibitors</subject><subject>Treatment Outcome</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Ultrasonography, Doppler - methods</subject><subject>Validity</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1v1DAQhiMEotvCmRuyhBACKa3tJP7gVq1airR8CEEPXKyJ43S9JPFiO6vuv-In4pDVInHBF3vsZ94Zz5tlzwg-J6RgF-Cbc4qxTFFVyuJBtiAlEznFDD_MFhjjIi8l4yfZaQibFGJBxOPshEheYomrRfbragfdCNG6AbkWBbMzHjo0dtFDcIO787Bd71HQztvhDoV9iKYPqHU-nQe3s9EGBEODtOu34G3KQdEh3dnB6iRk7qG3wx_9t8ibkIRTtnc9ArT1LmyNjnZnUJ8erDZD9AaFODb7qRu_NmMP0dkGgY9rPxV7kj1qoQvm6WE_y75dX31d3uSrT-_eLy9XeV0yEnNpQAohdSsa0EUtNONUYtYAbeumads0FCEIyKqGsirbSmvOsKSaUVFqTWVxlr2eddfQqa23Pfi9cmDVzeVKTXc4jRyXlO1IYl_NbPrRz9GEqHobtOk6GIwbg-JFWqWgNJEv_iE3bvRD-oginHPBMBFT7YuZ0mlCwZv22ADBavJdJd_V5LuafU8Zzw-6Y92b5i9_MDoBLw8AhORL62HQNhw5SllZUD6VzmfOJqPvj-_gfyjGC16pj7dLdfthSST-_EV9T_ybma_7zX-7_A2fCNbv</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Dougados, Maxime</creator><creator>Jousse-Joulin, Sandrine</creator><creator>Mistretta, Frederic</creator><creator>d'Agostino, Maria-Antonietta</creator><creator>Backhaus, Marina</creator><creator>Bentin, Jacques</creator><creator>Chalès, Gérard</creator><creator>Chary-Valckenaere, Isabelle</creator><creator>Conaghan, Philip</creator><creator>Etchepare, Fabien</creator><creator>Gaudin, Philippe</creator><creator>Grassi, Walter</creator><creator>van der Heijde, Désirée</creator><creator>Sellam, Jérémie</creator><creator>Naredo, Esperanza</creator><creator>Szkudlarek, Marcin</creator><creator>Wakefield, Richard</creator><creator>Saraux, Alain</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ Publishing Group</general><general>Elsevier Limited</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5479-5887</orcidid><orcidid>https://orcid.org/0000-0003-3386-6276</orcidid><orcidid>https://orcid.org/0000-0002-5781-158X</orcidid><orcidid>https://orcid.org/0000-0002-8454-7067</orcidid><orcidid>https://orcid.org/0000-0002-1814-6003</orcidid></search><sort><creationdate>20100501</creationdate><title>Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid arthritis</title><author>Dougados, Maxime ; Jousse-Joulin, Sandrine ; Mistretta, Frederic ; d'Agostino, Maria-Antonietta ; Backhaus, Marina ; Bentin, Jacques ; Chalès, Gérard ; Chary-Valckenaere, Isabelle ; Conaghan, Philip ; Etchepare, Fabien ; Gaudin, Philippe ; Grassi, Walter ; van der Heijde, Désirée ; Sellam, Jérémie ; Naredo, Esperanza ; Szkudlarek, Marcin ; Wakefield, Richard ; Saraux, Alain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b461t-9ea9889cf8dac3b8c672906da2fbddff967881a95ba454f5cc76092c6284cc293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Arthritis, Rheumatoid - diagnostic imaging</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Biological and medical sciences</topic><topic>Clinical trials</topic><topic>Diseases of the osteoarticular system</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Immunology</topic><topic>Inflammatory joint diseases</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Observer Variation</topic><topic>Patients</topic><topic>Physical Examination - methods</topic><topic>Studies</topic><topic>Synovitis - diagnostic imaging</topic><topic>Synovitis - drug therapy</topic><topic>Synovitis - pathology</topic><topic>TNF inhibitors</topic><topic>Treatment Outcome</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Tumor necrosis factor-TNF</topic><topic>Ultrasonography, Doppler - methods</topic><topic>Validity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dougados, Maxime</creatorcontrib><creatorcontrib>Jousse-Joulin, Sandrine</creatorcontrib><creatorcontrib>Mistretta, Frederic</creatorcontrib><creatorcontrib>d'Agostino, Maria-Antonietta</creatorcontrib><creatorcontrib>Backhaus, Marina</creatorcontrib><creatorcontrib>Bentin, Jacques</creatorcontrib><creatorcontrib>Chalès, Gérard</creatorcontrib><creatorcontrib>Chary-Valckenaere, Isabelle</creatorcontrib><creatorcontrib>Conaghan, Philip</creatorcontrib><creatorcontrib>Etchepare, Fabien</creatorcontrib><creatorcontrib>Gaudin, Philippe</creatorcontrib><creatorcontrib>Grassi, Walter</creatorcontrib><creatorcontrib>van der Heijde, Désirée</creatorcontrib><creatorcontrib>Sellam, Jérémie</creatorcontrib><creatorcontrib>Naredo, Esperanza</creatorcontrib><creatorcontrib>Szkudlarek, Marcin</creatorcontrib><creatorcontrib>Wakefield, Richard</creatorcontrib><creatorcontrib>Saraux, Alain</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dougados, Maxime</au><au>Jousse-Joulin, Sandrine</au><au>Mistretta, Frederic</au><au>d'Agostino, Maria-Antonietta</au><au>Backhaus, Marina</au><au>Bentin, Jacques</au><au>Chalès, Gérard</au><au>Chary-Valckenaere, Isabelle</au><au>Conaghan, Philip</au><au>Etchepare, Fabien</au><au>Gaudin, Philippe</au><au>Grassi, Walter</au><au>van der Heijde, Désirée</au><au>Sellam, Jérémie</au><au>Naredo, Esperanza</au><au>Szkudlarek, Marcin</au><au>Wakefield, Richard</au><au>Saraux, Alain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid arthritis</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>69</volume><issue>5</issue><spage>828</spage><epage>833</epage><pages>828-833</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Objectives To evaluate different global ultrasonographic (US) synovitis scoring systems as potential outcome measures of rheumatoid arthritis (RA) according to the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) filter. Methods To study selected global scoring systems, for the clinical, B mode and power Doppler techniques, the following joints were evaluated: 28 joints (28-joint Disease Activity Score (DAS28)), 20 joints (metacarpophalangeals (MCPs) + metatarsophalangeals (MTPs)) and 38 joints (28 joints + MTPs) using either a binary (yes/no) or a 0–3 grade. The study was a prospective, 4-month duration follow-up of 76 patients with RA requiring anti-tumour necrosis factor (TNF) therapy (complete follow-up data: 66 patients). Intraobserver reliability was evaluated using the intraclass correlation coefficient (ICC), construct validity was evaluated using the Cronbach α test and external validity was evaluated using level of correlation between scoring system and C reactive protein (CRP). Sensitivity to change was evaluated using the standardised response mean. Discriminating capacity was evaluated using the standardised mean differences in patients considered by the doctor as significantly improved or not at the end of the study. Results Different clinimetric properties of various US scoring systems were at least as good as the clinical scores with, for example, intraobserver reliability ranging from 0.61 to 0.97 versus from 0.53 to 0.82, construct validity ranging from 0.76 to 0.89 versus from 0.76 to 0.88, correlation with CRP ranging from 0.28 to 0.34 versus from 0.28 to 0.35 and sensitivity to change ranging from 0.60 to 1.21 versus from 0.96 to 1.36 for US versus clinical scoring systems, respectively. Conclusion This study suggests that US evaluation of synovitis is an outcome measure at least as relevant as physical examination. Further studies are required in order to achieve optimal US scoring systems for monitoring patients with RA in clinical trials and in clinical practice.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>19740905</pmid><doi>10.1136/ard.2009.115493</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5479-5887</orcidid><orcidid>https://orcid.org/0000-0003-3386-6276</orcidid><orcidid>https://orcid.org/0000-0002-5781-158X</orcidid><orcidid>https://orcid.org/0000-0002-8454-7067</orcidid><orcidid>https://orcid.org/0000-0002-1814-6003</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-4967 |
| ispartof | Annals of the rheumatic diseases, 2010-05, Vol.69 (5), p.828-833 |
| issn | 0003-4967 1468-2060 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01150426v1 |
| source | MEDLINE; BMJ Journals - NESLi2 |
| subjects | Adult Aged Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - diagnostic imaging Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - pathology Biological and medical sciences Clinical trials Diseases of the osteoarticular system Epidemiologic Methods Female Humans Hypotheses Immunology Inflammatory joint diseases Life Sciences Male Medical sciences Middle Aged Observer Variation Patients Physical Examination - methods Studies Synovitis - diagnostic imaging Synovitis - drug therapy Synovitis - pathology TNF inhibitors Treatment Outcome Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor necrosis factor-TNF Ultrasonography, Doppler - methods Validity |
| title | Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid arthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T08%3A33%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20several%20ultrasonography%20scoring%20systems%20for%20synovitis%20and%20comparison%20to%20clinical%20examination:%20results%20from%20a%20prospective%20multicentre%20study%20of%20rheumatoid%20arthritis&rft.jtitle=Annals%20of%20the%20rheumatic%20diseases&rft.au=Dougados,%20Maxime&rft.date=2010-05-01&rft.volume=69&rft.issue=5&rft.spage=828&rft.epage=833&rft.pages=828-833&rft.issn=0003-4967&rft.eissn=1468-2060&rft.coden=ARDIAO&rft_id=info:doi/10.1136/ard.2009.115493&rft_dat=%3Cproquest_hal_p%3E733334822%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1777860189&rft_id=info:pmid/19740905&rfr_iscdi=true |