A new route towards fimbrolide analogues: importance of the exomethylene motif in LuxR dependent quorum sensing inhibition

Sixteen analogues of fimbrolides (brominated 3-substituted-5-methylene-2(5H)-furanones), naturally occurring bacterial quorum sensing (QS) inhibitors, were synthesized by a novel sequence. The importance of the methylene group, either brominated or non-brominated, in LuxR-dependent QS inhibition was...

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Veröffentlicht in:	MedChemComm 2013, Vol.4 (2), p.363-366
Hauptverfasser:	Sabbah, Mohamad, Bernollin, Maud, Doutheau, Alain, Soulère, Laurent, Queneau, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Organic chemistry
Online-Zugang:	Volltext
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