Assembly-line synthesis of organic molecules with tailored shapes

Molecular ‘assembly lines’, in which organic molecules undergo iterative processes such as chain elongation and functional group manipulation, are found in many natural systems, including polyketide biosynthesis. Here we report the creation of such an assembly line using the iterative, reagent-contr...

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Veröffentlicht in:	Nature (London) 2014-09, Vol.513 (7517), p.183-188
Hauptverfasser:	Burns, Matthew, Essafi, Stéphanie, Bame, Jessica R., Bull, Stephanie P., Webster, Matthew P., Balieu, Sébastien, Dale, James W., Butts, Craig P., Harvey, Jeremy N., Aggarwal, Varinder K.
Format:	Artikel
Sprache:	eng
Schlagworte:	639/638/403 Analytical chemistry Binomial distribution Biosynthesis Boron Carbon Chemical research Chemical Sciences Chemical tests and reagents Chemistry Techniques, Synthetic - methods Chemistry Techniques, Synthetic - standards Esters Humanities and Social Sciences Magnetic Resonance Spectroscopy Molecular Conformation multidisciplinary Organic chemistry Organic compounds Physiological aspects Polyketides - chemical synthesis Polyketides - chemistry Science Stereoisomers Synthesis
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