Metabolism of N-methyl-amide by cytochrome P450s: Formation and characterization of highly stable carbinol-amide intermediate

We report unambiguous proof of the stability of a carbinol intermediate in the case of P450 metabolism of an N-methylated natural cyclo-peptide, namely tentoxin. Under mild acidic or neutral conditions, the lifetime of carbinol-amide is long enough to be fully characterized. This metabolite has been...

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Veröffentlicht in:The FEBS journal 2011-06, Vol.278 (12), p.2167-2178
Hauptverfasser: Perrin, Lionel, Loiseau, Nicolas, André, François, Delaforge, Marcel
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Sprache:eng
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