Fatal overdose after ingestion of a transdermal fentanyl patch in two non-human primates

Two non-human primates (Macaca fascicularis), weight 3.5 kg, enrolled in an experimental protocol received a 25 μg hour−1 transdermal fentanyl patch for postoperative analgesia. The following day both animals were clinically normal, but after a new induction of anaesthesia with ketamine, they develo...

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Veröffentlicht in:	Veterinary anaesthesia and analgesia 2012-11, Vol.39 (6), p.653-656
Hauptverfasser:	Deschamps, Jack-Yves, Gaulier, Jean-Michel, Podevin, Guillaume, Cherel, Yan, Ferry, Nicolas, Roux, Françoise A
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Sprache:	eng
Schlagworte:	Administration, Cutaneous Analgesics, Opioid - administration & dosage Analgesics, Opioid - poisoning Animals Drug Overdose - pathology Fentanyl - poisoning fentanyl patch Life Sciences Macaca fascicularis Male Naloxone - administration & dosage Naloxone - pharmacology Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacology opioids non human primate
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container_end_page	656
container_issue	6
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container_title	Veterinary anaesthesia and analgesia
container_volume	39
creator	Deschamps, Jack-Yves Gaulier, Jean-Michel Podevin, Guillaume Cherel, Yan Ferry, Nicolas Roux, Françoise A
description	Two non-human primates (Macaca fascicularis), weight 3.5 kg, enrolled in an experimental protocol received a 25 μg hour−1 transdermal fentanyl patch for postoperative analgesia. The following day both animals were clinically normal, but after a new induction of anaesthesia with ketamine, they developed severe and prolonged respiratory distress, profound coma and myosis. Attempted reversal with naloxone was ineffective. After several hours of ventilation, both primates eventually died, 7 and 15 hours after ketamine injection, respectively. In both cases, the patch was discovered in the animal's cheek pouch. Subsequent fentanyl serum concentration measurements (8.29 and 14.80 μg L−1) confirmed fentanyl overdose. This report of two fatal intoxications in non-human primates secondary to ingestion of a transdermal fentanyl patch demonstrates that this method of analgesia is inappropriate for non-human primates, because of their tendency to chew almost anything they can reach.
doi_str_mv	10.1111/j.1467-2995.2012.00749.x
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This report of two fatal intoxications in non-human primates secondary to ingestion of a transdermal fentanyl patch demonstrates that this method of analgesia is inappropriate for non-human primates, because of their tendency to chew almost anything they can reach.</description><identifier>ISSN: 1467-2987</identifier><identifier>EISSN: 1467-2995</identifier><identifier>DOI: 10.1111/j.1467-2995.2012.00749.x</identifier><identifier>PMID: 22789128</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Administration, Cutaneous ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - poisoning ; Animals ; Drug Overdose - pathology ; Fentanyl - poisoning ; fentanyl patch ; Life Sciences ; Macaca fascicularis ; Male ; Naloxone - administration & dosage ; Naloxone - pharmacology ; Narcotic Antagonists - administration & dosage ; Narcotic Antagonists - pharmacology ; opioids non human primate</subject><ispartof>Veterinary anaesthesia and analgesia, 2012-11, Vol.39 (6), p.653-656</ispartof><rights>2012 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia</rights><rights>2012 The Authors. 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This report of two fatal intoxications in non-human primates secondary to ingestion of a transdermal fentanyl patch demonstrates that this method of analgesia is inappropriate for non-human primates, because of their tendency to chew almost anything they can reach.</description><subject>Administration, Cutaneous</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - poisoning</subject><subject>Animals</subject><subject>Drug Overdose - pathology</subject><subject>Fentanyl - poisoning</subject><subject>fentanyl patch</subject><subject>Life Sciences</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Naloxone - administration & dosage</subject><subject>Naloxone - pharmacology</subject><subject>Narcotic Antagonists - administration & dosage</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>opioids non human primate</subject><issn>1467-2987</issn><issn>1467-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFvFCEUx4nRtLX6FQxXDzMCwxRIvKyNtSab9FKNN_JmAJfNLGyAbrvfXqZT96oc4AV-__fIDyFMSUvr-rRtKb8SDVOqbxmhrCVEcNU-vUIXp4fXp1qKc_Q25y0hVKienKFzxoRUlMkL9OsGCkw4HmwyMVsMrtiEffhtc_Ex4Ogw4JIgZGPTrpLOhgLhOOE9lHFTSVweIw4xNJuHHQS8T34HxeZ36I2DKdv3L-cl-nHz9f76tlnffft-vVo3Y0-pagRnkg8wMDMoLkknLBhHFHOcOyvAMAB5RThnYGQ3KOCj650bBieF7Ennukv0cem7gUk_D09HHcHr29Vaz3eE0k7U7UArKxd2TDHnZN0pQImexeqtnp3p2Z-exepnsfqpRj8s0f3DsLPmFPxrsgKfF-DRT_b43431z9WqFjX-ZYnb6urgbdJ59DaM1vhkx6JN9P_-5B-_KJyo</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Deschamps, Jack-Yves</creator><creator>Gaulier, Jean-Michel</creator><creator>Podevin, Guillaume</creator><creator>Cherel, Yan</creator><creator>Ferry, Nicolas</creator><creator>Roux, Françoise A</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-3363-7457</orcidid><orcidid>https://orcid.org/0000-0001-5191-9648</orcidid></search><sort><creationdate>201211</creationdate><title>Fatal overdose after ingestion of a transdermal fentanyl patch in two non-human primates</title><author>Deschamps, Jack-Yves ; 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The following day both animals were clinically normal, but after a new induction of anaesthesia with ketamine, they developed severe and prolonged respiratory distress, profound coma and myosis. Attempted reversal with naloxone was ineffective. After several hours of ventilation, both primates eventually died, 7 and 15 hours after ketamine injection, respectively. In both cases, the patch was discovered in the animal's cheek pouch. Subsequent fentanyl serum concentration measurements (8.29 and 14.80 μg L−1) confirmed fentanyl overdose. 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subjects	Administration, Cutaneous Analgesics, Opioid - administration & dosage Analgesics, Opioid - poisoning Animals Drug Overdose - pathology Fentanyl - poisoning fentanyl patch Life Sciences Macaca fascicularis Male Naloxone - administration & dosage Naloxone - pharmacology Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacology opioids non human primate
title	Fatal overdose after ingestion of a transdermal fentanyl patch in two non-human primates
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