Effects of endosulfan on hepatoma cell adhesion: Epithelial–mesenchymal transition and anoikis resistance

Highlights ► Endosulfan induces partial epithelial mesenchymal transition. ► Endosulfan permits a transient anoikis induction. ► HepG2 cells remain unable to acquire a motile phenotype after endosulfan treatment.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology (Amsterdam) 2012-10, Vol.300 (1), p.19-30
Hauptverfasser:	Peyre, Ludovic, Zucchini-Pascal, Nathalie, de Sousa, Georges, Rahmani, Roger
Format:	Artikel
Sprache:	eng
Schlagworte:	Anoikis Anoikis - drug effects beta Catenin - drug effects Biological and medical sciences Blotting, Western Caspases - metabolism Cell Adhesion - drug effects Cell Migration Assays Cytoskeleton - drug effects Dose-Response Relationship, Drug Emergency EMT Endosulfan Endosulfan - adverse effects Fluorescent Antibody Technique Gastroenterology. Liver. Pancreas. Abdomen Hep G2 Cells - drug effects Hepatocarcinoma HepG2 Humans Insecticides - adverse effects Life Sciences Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Pesticides, fertilizers and other agrochemicals toxicology Reverse Transcriptase Polymerase Chain Reaction rho-Associated Kinases - drug effects Signal Transduction - drug effects Toxicology Tumors Wnt Signaling Pathway - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► Endosulfan induces partial epithelial mesenchymal transition. ► Endosulfan permits a transient anoikis induction. ► HepG2 cells remain unable to acquire a motile phenotype after endosulfan treatment.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2012.05.008