Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial

Summary Background Despite optimum medical management, many patients with Parkinson's disease are incapacitated by gait disorders including freezing of gait. We aimed to assess whether methylphenidate—through its combined action on dopamine and noradrenaline reuptake—would improve gait disorder...

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Veröffentlicht in:	Lancet neurology 2012-07, Vol.11 (7), p.589-596
Hauptverfasser:	Moreau, Caroline, MD, Delval, Arnaud, MD, Defebvre, Luc, MD, Dujardin, Kathy, PhD, Duhamel, Alain, PhD, Petyt, Gregory, MD, Vuillaume, Isabelle, MD, Corvol, Jean-Christophe, MD, Brefel-Courbon, Christine, MD, Ory-Magne, Fabienne, MD, Guehl, Dominique, MD, Eusebio, Alexandre, MD, Fraix, Valérie, MD, Saulnier, Pierre-Jean, MD, Lagha-Boukbiza, Ouhaid, MD, Durif, Frank, MD, Faighel, Mirela, MD, Giordana, Caroline, MD, Drapier, Sophie, MD, Maltête, David, MD, Tranchant, Christine, MD, Houeto, Jean-Luc, MD, Debû, Bettina, MD, Sablonniere, Bernard, MD, Azulay, Jean-Philippe, MD, Tison, François, MD, Rascol, Olivier, MD, Vidailhet, Marie, MD, Destée, Alain, MD, Bloem, Bastiaan R, MD, Bordet, Régis, MD, Devos, David, Dr
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Clinical trials Computers Data processing Deep Brain Stimulation Dementia Dementia disorders Dopamine Dopamine Uptake Inhibitors - therapeutic use Double-Blind Method Drugs Electrical stimuli Female France Freezing Gait Gait Disorders, Neurologic - etiology Gait Disorders, Neurologic - therapy Humans Hypokinesia - etiology Hypokinesia - therapy Levodopa Life Sciences Male Methylphenidate Methylphenidate - therapeutic use Middle Aged Movement disorders Neurodegenerative diseases Neurology Norepinephrine Parkinson Disease - complications Parkinson Disease - therapy Parkinson's disease subthalamic nucleus Treatment Outcome
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