Glucocorticoids Can Induce PTSD-Like Memory Impairments in Mice

Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and by a memory impairment that decreases the ability to restrict fear to the appropriate context. Infusion of glucocorticoids in the hippocampus after fear conditioning induces PTSD-like memory impairments and an a...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2012-03, Vol.335 (6075), p.1510-1513
Hauptverfasser:	Kaouane, Nadia, Porte, Yves, Vallée, Monique, Brayda-Bruno, Laurent, Mons, Nicole, Calandreau, Ludovic, Marighetto, Aline, Piazza, Pier Vincenzo, Desmedt, Aline
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Amygdala - physiopathology Animal memory Animals Behavioral neuroscience Biological and medical sciences Cellular Biology Circuits Conditioning (Psychology) Corticosterone Corticosterone - administration & dosage Corticosterone - blood Corticosterone - metabolism Corticosterone - pharmacology Cues Electroshock Fear Fundamental and applied biological sciences. Psychology Glucocorticoids Hippocampus Hippocampus - physiopathology Life Sciences Male Memory Memory Disorders - chemically induced Memory Disorders - physiopathology Mice Mice, Inbred C57BL Neural conduction Neuropsychology Post traumatic stress disorder Posttraumatic Stress Disorder Proto-Oncogene Proteins c-fos - metabolism Restraint, Physical Rodents Steroids Stimuli Stress Disorders, Post-Traumatic - physiopathology Stress, Psychological Vertebrates: nervous system and sense organs White noise
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