Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers

The breakage-fusion-bridge cycle is a classical mechanism of telomere-driven genome instability in which dysfunctional telomeres are fused to other chromosomal extremities, creating dicentric chromosomes that eventually break at mitosis. Here, we uncover a distinct pathway of telomere-driven genome...

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Veröffentlicht in:	Cell 2015-02, Vol.160 (5), p.913-927
Hauptverfasser:	Marzec, Paulina, Armenise, Claudia, Pérot, Gaëlle, Roumelioti, Fani-Marlen, Basyuk, Eugenia, Gagos, Sarantis, Chibon, Frédéric, Déjardin, Jérôme
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomes, Human - metabolism DNA Breaks, Double-Stranded Genetics Genomic Instability Humans Life Sciences Neoplasms - genetics Receptors, N-Methyl-D-Aspartate - metabolism Telomere - metabolism Telomeric Repeat Binding Protein 2 - metabolism Translocation, Genetic
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