Detection of low-frequency HIV type 1 reverse transcriptase drug resistance mutations by ultradeep sequencing in naive HIV type 1-infected individuals

Genotypic resistance testing is recommended to evaluate the susceptibility of HIV to antiretroviral drugs. These tests are based on bulk population sequencing and thus consider only variants representing more than 20% of the viral population, whereas next generation sequencing methods allow detectio...

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Veröffentlicht in:	AIDS research and human retroviruses 2014-02, Vol.30 (2), p.170-173
Hauptverfasser:	Bellecave, Pantxika, Recordon-Pinson, Patricia, Papuchon, Jennifer, Vandenhende, Marie-Anne, Reigadas, Sandrine, Tauzin, Brigitte, Fleury, Hervé
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Drug Resistance, Viral France High-Throughput Nucleotide Sequencing HIV Infections - virology HIV Reverse Transcriptase - genetics HIV-1 - genetics HIV-1 - isolation & purification Human immunodeficiency virus 1 Humans Life Sciences Microbiology and Parasitology Mutation, Missense Retrovirus
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