Energy restriction mimetic agents to target cancer cells: Comparison between 2-deoxyglucose and thiazolidinediones

The use of energy restriction mimetic agents (ERMAs) to selectively target cancer cells addicted to glycolysis could be a promising therapeutic approach. Thiazolidinediones (TZDs) are synthetic agonists of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ that were developed to...

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Veröffentlicht in:	Biochemical pharmacology 2014-11, Vol.92 (1), p.102-111
Hauptverfasser:	Kuntz, Sandra, Mazerbourg, Sabine, Boisbrun, Michel, Cerella, Claudia, Diederich, Marc, Grillier-Vuissoz, Isabelle, Flament, Stephane
Format:	Artikel
Sprache:	eng
Schlagworte:	2-deoxyglucose, Thiazolidinediones Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Autophagy - drug effects Cancer Cell Line, Tumor Deoxyglucose - pharmacology Deoxyglucose - therapeutic use Energy Metabolism - drug effects Glucose metabolism Humans Life Sciences Neoplasms - drug therapy Neoplasms - pathology Thiazolidinediones - pharmacology Thiazolidinediones - therapeutic use Warburg effect
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