Functional and Structural Characterization of 2‑Amino-4-phenylthiazole Inhibitors of the HIV‑1 Nucleocapsid Protein with Antiviral Activity

The nucleocapsid protein (NC) is a highly conserved protein in diverse HIV-1 subtypes that plays a central role in virus replication, mainly by interacting with conserved nucleic acid sequences. NC is considered a highly profitable drug target to inhibit multiple steps in the HIV-1 life cycle with j...

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