S-Adenosylmethionine-dependent radical-based modification of biological macromolecules

Proteins and RNA molecules enjoy a variety of chemically complex post-translational and post-transcriptional modifications. The chemistry at work in these reactions, which was considered to be exclusively ionic in nature has recently been shown to depend on radical mechanisms in some cases. The over...

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Veröffentlicht in:	Current opinion in structural biology 2010-12, Vol.20 (6), p.684-692
Hauptverfasser:	Atta, Mohamed, Mulliez, Etienne, Arragain, Simon, Forouhar, Farhad, Hunt, John F, Fontecave, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Chemical Sciences Enzymes - chemistry Enzymes - metabolism Free Radicals - metabolism Humans Inorganic chemistry Proteins - chemistry Proteins - metabolism RNA - chemistry RNA - metabolism S-Adenosylmethionine - metabolism
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