A Chinese 2-herb formula (NF3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats

Abstract Diabetic foot ulcer is closely associated with peripheral vascular disease. Enhancement of tissue oxidative stress, reduction of nitric oxide (NO) and angiogenic growth factors, and abnormal matrix metalloproteinase (MMP) activity are pathophysiological factors in post-ischemic neovasculari...

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Veröffentlicht in:	Journal of diabetes and its complications 2014-07, Vol.28 (4), p.436-447
Hauptverfasser:	Tam, Jacqueline Chor-Wing, Ko, Chun-Hay, Lau, Kit-Man, To, Ming-Ho, Kwok, Hin-Fai, Chan, Yuet-Wa, Siu, Wing-Sum, Etienne-Selloum, Nelly, Lau, Ching-Po, Chan, Wai-Yee, Leung, Ping-Chung, Fung, Kwok-Pui, Schini-Kerth, Valérie B, Lau, Clara Bik-San
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inducing Agents - therapeutic use Animals Astragalus membranaceus Biomarkers - blood Biomarkers - metabolism Chinese medicine Chinese medicines Diabetes Diabetic foot Diabetic Foot - drug therapy Diabetic Foot - etiology Diabetic Foot - metabolism Diabetic Foot - pathology Disease Models, Animal Drugs, Chinese Herbal - therapeutic use Endocrinology & Metabolism Endothelial Progenitor Cells - drug effects Endothelial Progenitor Cells - metabolism Endothelial Progenitor Cells - pathology Enzymes Feet Female Foot diseases Functional foods & nutraceuticals Gene expression Hindlimb Hindlimb ischemia Hyperglycemia Hypoxia Ischemia Ischemia - physiopathology Life Sciences Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Migration Muscle, Skeletal - blood supply Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Neovascularization, Physiologic - drug effects Nitric Oxide Synthase Type III - chemistry Nitric Oxide Synthase Type III - metabolism Oxidative stress Oxidative Stress - drug effects Quality control Rats, Wistar Rehmannia glutinosa Rodents Studies Ulcers Up-Regulation - drug effects Vascular endothelial growth factor Vascular Endothelial Growth Factor A - agonists Vascular Endothelial Growth Factor A - metabolism Wound healing Wound Healing - drug effects
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