A multicenter blinded study evaluating EGFR and KRAS mutation testing methods in the clinical non-small cell lung cancer setting--IFCT/ERMETIC2 Project Part 1: Comparison of testing methods in 20 French molecular genetic National Cancer Institute platforms

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors have limited use as first-line treatment for mutated EGFR metastatic non-small cell lung cancer. The French National Cancer Institute has installed molecular genetics platforms implementing EGFR and KRAS testing. However, there is co...

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Veröffentlicht in:	The Journal of molecular diagnostics : JMD 2014-01, Vol.16 (1), p.45-55
Hauptverfasser:	Beau-Faller, Michèle, Blons, Hélène, Domerg, Caroline, Gajda, Dorota, Richard, Nicolas, Escande, Fabienne, Solassol, Jérôme, Denis, Marc G, Cayre, Anne, Nanni-Metellus, Isabelle, Olschwang, Sylviane, Lizard, Sarab, Piard, Fabienne, Pretet, Jean-Luc, de Fraipont, Florence, Bièche, Ivan, de Cremoux, Patricia, Rouquette, Isabelle, Bringuier, Pierre-Paul, Mosser, Jean, Legrain, Michèle, Voegeli, Anne-Claire, Saulnier, Patrick, Morin, Franck, Pignon, Jean-Pierre, Zalcman, Gérard, Cadranel, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnosis Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma of Lung Antineoplastic Agents - therapeutic use Base Sequence Cancer Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Cell Line, Tumor ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Erlotinib Hydrochloride False Positive Reactions Gefitinib Genetics Genotype High-Throughput Nucleotide Sequencing - methods Humans Life Sciences Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Lung Neoplasms - genetics Molecular Diagnostic Techniques - methods Nucleic Acid Amplification Techniques Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) Quinazolines - therapeutic use ras Proteins - genetics Sequence Analysis, DNA - methods
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