Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility

Epithelial-to-mesenchymal transition (EMT) promotes cell motility, which is important for the metastasis of malignant cells, and blocks CD95-mediated apoptotic signaling triggered by immune cells and chemotherapeutic regimens. CD95L, the cognate ligand of CD95, can be cleaved by metalloproteases and...

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Veröffentlicht in:	Oncogene 2015-02, Vol.34 (8), p.996-1005
Hauptverfasser:	Edmond, V, Dufour, F, Poiroux, G, Shoji, K, Malleter, M, Fouqué, A, Tauzin, S, Rimokh, R, Sergent, O, Penna, A, Dupuy, A, Levade, T, Theret, N, Micheau, O, Ségui, B, Legembre, P
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1347 631/67/322 631/80/84/2176 631/80/86 Apoptosis Cancer CD95 antigen Cell adhesion & migration Cell Biology Cell Membrane - physiology Cell migration Cell Movement - genetics Cells, Cultured Cellular biology Ceramide Down-Regulation Epithelial-Mesenchymal Transition - genetics FasL protein Fluidity Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genetic research HL-60 Cells Human Genetics Humans Internal Medicine Jurkat Cells K562 Cells Life Sciences Lipids Medicine Medicine & Public Health Membrane fluidity Membrane Fluidity - genetics Membrane proteins Membrane Proteins - genetics Membranes Mesenchyme Metastases Metastasis Motility Neoplasms - pathology Oncology Oncology, Experimental original-article Plasma Properties Proteins Sphingolipids Sphingosine N-Acyltransferase - genetics Studies Tumor cell lines
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