Classification of axial SpA based on positive imaging (radiographs and/or MRI of the sacroiliac joints) by local rheumatologists or radiologists versus central trained readers in the DESIR cohort

ObjectiveInvestigating changes in patient classification (ASAS (Assessment of SpondyloArthritis international Society) axSpA criteria) based on evaluation of images of the sacro-iliac joints (MRI-SI and X-SI) by local and central readers.MethodsThe DESIR cohort included patients with inflammatory ba...

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Veröffentlicht in:Annals of the rheumatic diseases 2015-11, Vol.74 (11), p.2016-2021
Hauptverfasser: van den Berg, Rosaline, Lenczner, Grégory, Thévenin, Fabrice, Claudepierre, Pascal, Feydy, Antoine, Reijnierse, Monique, Saraux, Alain, Rahmouni, Alain, Dougados, Maxime, van der Heijde, Désirée
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container_end_page 2021
container_issue 11
container_start_page 2016
container_title Annals of the rheumatic diseases
container_volume 74
creator van den Berg, Rosaline
Lenczner, Grégory
Thévenin, Fabrice
Claudepierre, Pascal
Feydy, Antoine
Reijnierse, Monique
Saraux, Alain
Rahmouni, Alain
Dougados, Maxime
van der Heijde, Désirée
description ObjectiveInvestigating changes in patient classification (ASAS (Assessment of SpondyloArthritis international Society) axSpA criteria) based on evaluation of images of the sacro-iliac joints (MRI-SI and X-SI) by local and central readers.MethodsThe DESIR cohort included patients with inflammatory back pain (IBP; ≥3 months, but
doi_str_mv 10.1136/annrheumdis-2014-205432
format Article
fullrecord <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01030844v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808617707</sourcerecordid><originalsourceid>FETCH-LOGICAL-b451t-f5bd85647af8b3895aa6883a37c9a264742d92357bcd191c1a9490a881396f333</originalsourceid><addsrcrecordid>eNqNksFu1DAQhiMEokvhFcASl_YQasdO7BxXS6ErLUJq4RxNEmfjVWIvtrOiz8eLMbtpK8QFLmPN-JvfY_tPkneMfmCMF1dgre_1NLYmpBllAkMuePYsWTBRKMwK-jxZUEp5KspCniWvQthhShVTL5OzDIuZkmyR_FoNEILpTAPROEtcR-CngYHc7ZekhqBbgtW9CyaagyZmhK2xW3LhoTVu62HfBwK2vXKefLldH9tjr0mAxjszGGjIzhkbwyWp78ngGhQ-zQ3RDW5rQgwEO09ij_lB-zAF0mgbPeIYjMUpvIYWd4ixpxM-Xt-tb0njeufj6-RFB0PQbx7W8-T7p-tvq5t08_XzerXcpLXIWUy7vG5VXggJnaq5KnOAQikOXDYlZFgXWVtmPJd107KSNQxKUVJQivGy6Djn58nlrNvDUO09voW_rxyY6ma5qY41yiinSogDQ_ZiZvfe_Zh0iNVoQqOHAax2U6iYoqpgUlL5b1RmjItCZAWi7_9Cd27yFi-NlJRKoGiJlJwp_IQQvO6ehmW0Otqn-sM-1dE-1Wwf7Hz7oD_Vo26f-h79gkA2A_W4-2_V3xES1Wc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1777840869</pqid></control><display><type>article</type><title>Classification of axial SpA based on positive imaging (radiographs and/or MRI of the sacroiliac joints) by local rheumatologists or radiologists versus central trained readers in the DESIR cohort</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>van den Berg, Rosaline ; Lenczner, Grégory ; Thévenin, Fabrice ; Claudepierre, Pascal ; Feydy, Antoine ; Reijnierse, Monique ; Saraux, Alain ; Rahmouni, Alain ; Dougados, Maxime ; van der Heijde, Désirée</creator><creatorcontrib>van den Berg, Rosaline ; Lenczner, Grégory ; Thévenin, Fabrice ; Claudepierre, Pascal ; Feydy, Antoine ; Reijnierse, Monique ; Saraux, Alain ; Rahmouni, Alain ; Dougados, Maxime ; van der Heijde, Désirée</creatorcontrib><description>ObjectiveInvestigating changes in patient classification (ASAS (Assessment of SpondyloArthritis international Society) axSpA criteria) based on evaluation of images of the sacro-iliac joints (MRI-SI and X-SI) by local and central readers.MethodsThe DESIR cohort included patients with inflammatory back pain (IBP; ≥3 months, but &lt;3 years), suggestive of axSpA. Local radiologists/rheumatologists (local-reading) and two central readers (central-reading) evaluated baseline images. Agreement regarding positive MRI (pos-MRI) between central readers and between local-reading and central-reading was calculated (κs). Number of patients classified differently (ASAS criteria) by using local-reading instead of central-reading was calculated.ResultsInter-reader agreement between the two central readers and between local-reading and central-reading was substantial (κ=0.73 and κ=0.70, respectively). In 89/663 MRI-SIs (13.4%) local-reading and central-reading disagreed; 38/223 patients (17.0%) with pos-MRI (local-reading) were negative by central-reading; 51/440 patients (11.6%) with neg-MRI (local-reading) were positive by central-reading.In 163/582 patients eligible for applying ASAS criteria (28.0%), local-reading and central-reading disagreed on positive imaging (MRI-SI and/or X-SI; κ=0.68). In 46/582 patients (7.9%) a different evaluation resulted in a different classification; 18/582 patients (3.1%) classified no-SpA (central-reading) were axSpA by local-reading; 28/582 patients (4.8%) classified axSpA (central-reading) were no-SpA by local-reading. Among axSpA patients (central-reading), 16/419 patients (3.8%) fulfilling imaging-arm by central-reading fulfilled clinical-arm by local-reading; 29/419 patients (6.9%) fulfilling clinical-arm by central-reading fulfilled also imaging-arm by local-reading.ConclusionsIn patients with recent onset IBP, trained readers and local rheumatologists/radiologists agree well on recognising a pos-MRI. While disagreeing in 28% of the patients on positive imaging (MRI-SI and/or X-SI), classification of only 7.9% of the patients changed based on a different evaluation of images, showing the ASAS axSpA criteria's robustness.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2014-205432</identifier><identifier>PMID: 24962871</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>England: Elsevier Limited</publisher><subject>Adolescent ; Adult ; Agreements ; Back pain ; Back Pain - etiology ; Back Pain - pathology ; Classification ; Clinical medicine ; Clinical trials ; Cohort Studies ; Edema ; Female ; Humans ; Laboratories ; Life Sciences ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Observer Variation ; Patients ; Prospective Studies ; Radiology - standards ; Reading ; Rheumatology - standards ; Sacroiliac Joint - pathology ; Sacroiliitis - complications ; Sacroiliitis - pathology ; Severity of Illness Index ; Spondylarthropathies - complications ; Spondylarthropathies - pathology ; Spondylitis, Ankylosing - complications ; Spondylitis, Ankylosing - pathology ; Young Adult</subject><ispartof>Annals of the rheumatic diseases, 2015-11, Vol.74 (11), p.2016-2021</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b451t-f5bd85647af8b3895aa6883a37c9a264742d92357bcd191c1a9490a881396f333</citedby><cites>FETCH-LOGICAL-b451t-f5bd85647af8b3895aa6883a37c9a264742d92357bcd191c1a9490a881396f333</cites><orcidid>0000-0002-8454-7067 ; 0000-0002-5781-158X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/74/11/2016.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/74/11/2016.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,776,780,881,3183,23550,27901,27902,77342,77373</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24962871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-brest.fr/hal-01030844$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>van den Berg, Rosaline</creatorcontrib><creatorcontrib>Lenczner, Grégory</creatorcontrib><creatorcontrib>Thévenin, Fabrice</creatorcontrib><creatorcontrib>Claudepierre, Pascal</creatorcontrib><creatorcontrib>Feydy, Antoine</creatorcontrib><creatorcontrib>Reijnierse, Monique</creatorcontrib><creatorcontrib>Saraux, Alain</creatorcontrib><creatorcontrib>Rahmouni, Alain</creatorcontrib><creatorcontrib>Dougados, Maxime</creatorcontrib><creatorcontrib>van der Heijde, Désirée</creatorcontrib><title>Classification of axial SpA based on positive imaging (radiographs and/or MRI of the sacroiliac joints) by local rheumatologists or radiologists versus central trained readers in the DESIR cohort</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>ObjectiveInvestigating changes in patient classification (ASAS (Assessment of SpondyloArthritis international Society) axSpA criteria) based on evaluation of images of the sacro-iliac joints (MRI-SI and X-SI) by local and central readers.MethodsThe DESIR cohort included patients with inflammatory back pain (IBP; ≥3 months, but &lt;3 years), suggestive of axSpA. Local radiologists/rheumatologists (local-reading) and two central readers (central-reading) evaluated baseline images. Agreement regarding positive MRI (pos-MRI) between central readers and between local-reading and central-reading was calculated (κs). Number of patients classified differently (ASAS criteria) by using local-reading instead of central-reading was calculated.ResultsInter-reader agreement between the two central readers and between local-reading and central-reading was substantial (κ=0.73 and κ=0.70, respectively). In 89/663 MRI-SIs (13.4%) local-reading and central-reading disagreed; 38/223 patients (17.0%) with pos-MRI (local-reading) were negative by central-reading; 51/440 patients (11.6%) with neg-MRI (local-reading) were positive by central-reading.In 163/582 patients eligible for applying ASAS criteria (28.0%), local-reading and central-reading disagreed on positive imaging (MRI-SI and/or X-SI; κ=0.68). In 46/582 patients (7.9%) a different evaluation resulted in a different classification; 18/582 patients (3.1%) classified no-SpA (central-reading) were axSpA by local-reading; 28/582 patients (4.8%) classified axSpA (central-reading) were no-SpA by local-reading. Among axSpA patients (central-reading), 16/419 patients (3.8%) fulfilling imaging-arm by central-reading fulfilled clinical-arm by local-reading; 29/419 patients (6.9%) fulfilling clinical-arm by central-reading fulfilled also imaging-arm by local-reading.ConclusionsIn patients with recent onset IBP, trained readers and local rheumatologists/radiologists agree well on recognising a pos-MRI. While disagreeing in 28% of the patients on positive imaging (MRI-SI and/or X-SI), classification of only 7.9% of the patients changed based on a different evaluation of images, showing the ASAS axSpA criteria's robustness.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Agreements</subject><subject>Back pain</subject><subject>Back Pain - etiology</subject><subject>Back Pain - pathology</subject><subject>Classification</subject><subject>Clinical medicine</subject><subject>Clinical trials</subject><subject>Cohort Studies</subject><subject>Edema</subject><subject>Female</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Radiology - standards</subject><subject>Reading</subject><subject>Rheumatology - standards</subject><subject>Sacroiliac Joint - pathology</subject><subject>Sacroiliitis - complications</subject><subject>Sacroiliitis - pathology</subject><subject>Severity of Illness Index</subject><subject>Spondylarthropathies - complications</subject><subject>Spondylarthropathies - pathology</subject><subject>Spondylitis, Ankylosing - complications</subject><subject>Spondylitis, Ankylosing - pathology</subject><subject>Young Adult</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNksFu1DAQhiMEokvhFcASl_YQasdO7BxXS6ErLUJq4RxNEmfjVWIvtrOiz8eLMbtpK8QFLmPN-JvfY_tPkneMfmCMF1dgre_1NLYmpBllAkMuePYsWTBRKMwK-jxZUEp5KspCniWvQthhShVTL5OzDIuZkmyR_FoNEILpTAPROEtcR-CngYHc7ZekhqBbgtW9CyaagyZmhK2xW3LhoTVu62HfBwK2vXKefLldH9tjr0mAxjszGGjIzhkbwyWp78ngGhQ-zQ3RDW5rQgwEO09ij_lB-zAF0mgbPeIYjMUpvIYWd4ixpxM-Xt-tb0njeufj6-RFB0PQbx7W8-T7p-tvq5t08_XzerXcpLXIWUy7vG5VXggJnaq5KnOAQikOXDYlZFgXWVtmPJd107KSNQxKUVJQivGy6Djn58nlrNvDUO09voW_rxyY6ma5qY41yiinSogDQ_ZiZvfe_Zh0iNVoQqOHAax2U6iYoqpgUlL5b1RmjItCZAWi7_9Cd27yFi-NlJRKoGiJlJwp_IQQvO6ehmW0Otqn-sM-1dE-1Wwf7Hz7oD_Vo26f-h79gkA2A_W4-2_V3xES1Wc</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>van den Berg, Rosaline</creator><creator>Lenczner, Grégory</creator><creator>Thévenin, Fabrice</creator><creator>Claudepierre, Pascal</creator><creator>Feydy, Antoine</creator><creator>Reijnierse, Monique</creator><creator>Saraux, Alain</creator><creator>Rahmouni, Alain</creator><creator>Dougados, Maxime</creator><creator>van der Heijde, Désirée</creator><general>Elsevier Limited</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>7TS</scope><scope>H94</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-8454-7067</orcidid><orcidid>https://orcid.org/0000-0002-5781-158X</orcidid></search><sort><creationdate>20151101</creationdate><title>Classification of axial SpA based on positive imaging (radiographs and/or MRI of the sacroiliac joints) by local rheumatologists or radiologists versus central trained readers in the DESIR cohort</title><author>van den Berg, Rosaline ; Lenczner, Grégory ; Thévenin, Fabrice ; Claudepierre, Pascal ; Feydy, Antoine ; Reijnierse, Monique ; Saraux, Alain ; Rahmouni, Alain ; Dougados, Maxime ; van der Heijde, Désirée</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b451t-f5bd85647af8b3895aa6883a37c9a264742d92357bcd191c1a9490a881396f333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Agreements</topic><topic>Back pain</topic><topic>Back Pain - etiology</topic><topic>Back Pain - pathology</topic><topic>Classification</topic><topic>Clinical medicine</topic><topic>Clinical trials</topic><topic>Cohort Studies</topic><topic>Edema</topic><topic>Female</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Life Sciences</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observer Variation</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Radiology - standards</topic><topic>Reading</topic><topic>Rheumatology - standards</topic><topic>Sacroiliac Joint - pathology</topic><topic>Sacroiliitis - complications</topic><topic>Sacroiliitis - pathology</topic><topic>Severity of Illness Index</topic><topic>Spondylarthropathies - complications</topic><topic>Spondylarthropathies - pathology</topic><topic>Spondylitis, Ankylosing - complications</topic><topic>Spondylitis, Ankylosing - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van den Berg, Rosaline</creatorcontrib><creatorcontrib>Lenczner, Grégory</creatorcontrib><creatorcontrib>Thévenin, Fabrice</creatorcontrib><creatorcontrib>Claudepierre, Pascal</creatorcontrib><creatorcontrib>Feydy, Antoine</creatorcontrib><creatorcontrib>Reijnierse, Monique</creatorcontrib><creatorcontrib>Saraux, Alain</creatorcontrib><creatorcontrib>Rahmouni, Alain</creatorcontrib><creatorcontrib>Dougados, Maxime</creatorcontrib><creatorcontrib>van der Heijde, Désirée</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; 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≥3 months, but &lt;3 years), suggestive of axSpA. Local radiologists/rheumatologists (local-reading) and two central readers (central-reading) evaluated baseline images. Agreement regarding positive MRI (pos-MRI) between central readers and between local-reading and central-reading was calculated (κs). Number of patients classified differently (ASAS criteria) by using local-reading instead of central-reading was calculated.ResultsInter-reader agreement between the two central readers and between local-reading and central-reading was substantial (κ=0.73 and κ=0.70, respectively). In 89/663 MRI-SIs (13.4%) local-reading and central-reading disagreed; 38/223 patients (17.0%) with pos-MRI (local-reading) were negative by central-reading; 51/440 patients (11.6%) with neg-MRI (local-reading) were positive by central-reading.In 163/582 patients eligible for applying ASAS criteria (28.0%), local-reading and central-reading disagreed on positive imaging (MRI-SI and/or X-SI; κ=0.68). In 46/582 patients (7.9%) a different evaluation resulted in a different classification; 18/582 patients (3.1%) classified no-SpA (central-reading) were axSpA by local-reading; 28/582 patients (4.8%) classified axSpA (central-reading) were no-SpA by local-reading. Among axSpA patients (central-reading), 16/419 patients (3.8%) fulfilling imaging-arm by central-reading fulfilled clinical-arm by local-reading; 29/419 patients (6.9%) fulfilling clinical-arm by central-reading fulfilled also imaging-arm by local-reading.ConclusionsIn patients with recent onset IBP, trained readers and local rheumatologists/radiologists agree well on recognising a pos-MRI. While disagreeing in 28% of the patients on positive imaging (MRI-SI and/or X-SI), classification of only 7.9% of the patients changed based on a different evaluation of images, showing the ASAS axSpA criteria's robustness.</abstract><cop>England</cop><pub>Elsevier Limited</pub><pmid>24962871</pmid><doi>10.1136/annrheumdis-2014-205432</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8454-7067</orcidid><orcidid>https://orcid.org/0000-0002-5781-158X</orcidid></addata></record>
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source MEDLINE; BMJ Journals - NESLi2
subjects Adolescent
Adult
Agreements
Back pain
Back Pain - etiology
Back Pain - pathology
Classification
Clinical medicine
Clinical trials
Cohort Studies
Edema
Female
Humans
Laboratories
Life Sciences
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Observer Variation
Patients
Prospective Studies
Radiology - standards
Reading
Rheumatology - standards
Sacroiliac Joint - pathology
Sacroiliitis - complications
Sacroiliitis - pathology
Severity of Illness Index
Spondylarthropathies - complications
Spondylarthropathies - pathology
Spondylitis, Ankylosing - complications
Spondylitis, Ankylosing - pathology
Young Adult
title Classification of axial SpA based on positive imaging (radiographs and/or MRI of the sacroiliac joints) by local rheumatologists or radiologists versus central trained readers in the DESIR cohort
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