Genetic and functional evaluation of MITF as a candidate gene for cutaneous melanoma predisposition in pigs

Cutaneous melanoma arises from transformed melanocytes and is caused mainly by environmental effects such as ultraviolet radiation and to a lesser extent by predisposing genetic variants. Only a few susceptibility genes for cutaneous melanoma have been identified so far in human; therefore, animal m...

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Veröffentlicht in:	Mammalian genome 2011-10, Vol.22 (9-10), p.602-612
Hauptverfasser:	Bourneuf, Emmanuelle, Du, Zhi-Qiang, Estellé, Jordi, Gilbert, Hélène, Créchet, Françoise, Piton, Guillaume, Milan, Denis, Geffrotin, Claudine, Lathrop, Mark, Demenais, Florence, Rogel-Gaillard, Claire, Vincent-Naulleau, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Agricultural sciences Animal Genetics and Genomics animal models Animals Biomedical and Life Sciences Cell Biology Female Gene Expression Regulation genes Genetic Linkage Genetic Predisposition to Disease Human Genetics humans Life Sciences loci Male melanocytes melanoma Melanoma - genetics Melanoma - metabolism Microphthalmia-Associated Transcription Factor - genetics Microphthalmia-Associated Transcription Factor - metabolism microsatellite repeats Molecular Sequence Data Polymorphism, Single Nucleotide Quantitative Trait Loci RNA, Messenger single nucleotide polymorphism Skin Neoplasms - genetics Skin Neoplasms - metabolism Sus scrofa swine transcription (genetics) transcription factors ultraviolet radiation
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