overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions
The characterization of the mechanisms underlying skeletal muscle atrophy under different conditions has been a constant focus of research. Among anti-atrophic therapies, amino acid supplementation, particularly with leucine, has received a lot of attention. Supplementation has been shown to have re...
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| Veröffentlicht in: | Amino acids 2011-02, Vol.40 (2), p.287-300 |
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| creator | Nicastro, Humberto Artioli, Guilherme Giannini dos Santos Costa, André Solis, Marina Yazigi da Luz, Claudia Ribeiro Blachier, François Lancha, Antonio Herbert Jr |
| description | The characterization of the mechanisms underlying skeletal muscle atrophy under different conditions has been a constant focus of research. Among anti-atrophic therapies, amino acid supplementation, particularly with leucine, has received a lot of attention. Supplementation has been shown to have remarkable effects on muscle remodeling through protein turnover modulation. This may then impact physiological parameters related to muscle function, and even quality of life. In light of this, leucine supplementation could be a useful therapy for mitigating the atrophic effects of catabolic conditions. The purpose of this review is to present the major results of human studies evaluating the effects of leucine supplementation on structure and function of skeletal muscle in atrophic conditions such as muscle disuse, sarcopenia, and cancer. |
| doi_str_mv | 10.1007/s00726-010-0636-x |
| format | Article |
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Among anti-atrophic therapies, amino acid supplementation, particularly with leucine, has received a lot of attention. Supplementation has been shown to have remarkable effects on muscle remodeling through protein turnover modulation. This may then impact physiological parameters related to muscle function, and even quality of life. In light of this, leucine supplementation could be a useful therapy for mitigating the atrophic effects of catabolic conditions. 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Among anti-atrophic therapies, amino acid supplementation, particularly with leucine, has received a lot of attention. Supplementation has been shown to have remarkable effects on muscle remodeling through protein turnover modulation. This may then impact physiological parameters related to muscle function, and even quality of life. In light of this, leucine supplementation could be a useful therapy for mitigating the atrophic effects of catabolic conditions. 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| subjects | Agricultural sciences Analytical Chemistry atrophy Biochemical Engineering Biochemistry Biomedical and Life Sciences Branched-chain amino acids Clinical Trials as Topic Dietary Supplements - utilization Disuse Humans leucine Leucine - adverse effects Leucine - therapeutic use Life Sciences Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Muscular Atrophy - drug therapy Muscular Diseases - drug therapy Muscular Diseases - pathology Neoplasms - drug therapy Neurobiology Proteomics Review Article skeletal muscle |
| title | overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions |
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