IL6 and TNF expression in vessels and surrounding tissues after embolization with ibuprofen-loaded beads confirms diffusion of ibuprofen

Ibuprofen from loaded embolization beads released in tissues and induced over-expression of IL6 beyond the vascular wall, in the surrounding tissues, which confirmed diffusion of the drug in a gradient of concentration. In the treatment of uterine fibroid embolization related pain, the use of emboli...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2011-04, Vol.42 (5), p.489-495
Hauptverfasser:	Verret, Valentin, Bevilacqua, Claudia, Schwartz-Cornil, Isabelle, Pelage, Jean-Pierre, Wassef, Michel, Namur, Julien, Bédouet, Laurent, Lewis, Andrew L., Martin, Patrice, Laurent, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	Agricultural sciences Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Delayed-Action Preparations Drug Delivery Systems - methods Drug-delivery Embolization Female Gene Expression - drug effects General pharmacology Ibuprofen Ibuprofen - administration & dosage Ibuprofen - pharmacokinetics Ibuprofen - therapeutic use IL6 Interleukin-6 - biosynthesis Interleukin-6 - genetics Lasers Leiomyoma - blood supply Leiomyoma - surgery Life Sciences Medical sciences Microdissection Microspheres Pain, Postoperative - prevention & control Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Quantitative-PCR Reverse Transcriptase Polymerase Chain Reaction Sheep Tissue Distribution Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Uterine Artery - drug effects Uterine Artery - immunology Uterine Artery - pathology Uterine Artery Embolization - methods Uterine Neoplasms - blood supply Uterine Neoplasms - surgery Uterus - drug effects Uterus - immunology Uterus - pathology
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