Synthesis of BC Ring-Systems of Taxol by Ring-Closing Metathesis

Highly functionalized BC ring-systems of Taxol® having the required chemistry for the C1, C2 and C8 centers have been synthesized using a ring- closing metathesis (RCM) reaction as the key step. Silylene 26 and acetonide 27 were obtained in excellent yields with Schrock's and our recently repor...

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Veröffentlicht in:Synthesis (Stuttgart) 2000, Vol.2000 (6), p.869-882
Hauptverfasser: Bourgeois, Damien, Mahuteau, Jacqueline, Pancrazi, Ange, Nolan, Steven P., Prunet, Joëlle
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Sprache:eng
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