Streptococcus bovis/Streptococcus equinus complex fecal carriage, colorectal carcinoma, and infective endocarditis: a new appraisal of a complex connection
The proportion of group D streptococcal infective endocarditis (IE) (predominantly due to Streptococcus gallolyticus ) and the incidence of colorectal cancer are higher in France than in most European countries. We assumed that this could be explained by a high group D streptococci (GDS) fecal carri...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2013-09, Vol.32 (9), p.1171-1176 |
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| creator | Chirouze, C. Patry, I. Duval, X. Baty, V. Tattevin, P. Aparicio, T. Pagenault, M. Carbonnel, F. Couetdic, G. Hoen, B. |
| description | The proportion of group D streptococcal infective endocarditis (IE) (predominantly due to
Streptococcus gallolyticus
) and the incidence of colorectal cancer are higher in France than in most European countries. We assumed that this could be explained by a high group D streptococci (GDS) fecal carriage rate. The aims of this study were to re-assess the GDS fecal carriage rate in France and its relationship with colorectal cancer. Consecutive adult subjects who were to undergo a complete colonoscopy were invited to participate. GDS were searched in subjects’ stools before their colonoscopy using biomolecular techniques. Colonoscopic findings were sorted into four subgroups: normal colonoscopy, non-tumoral lesions, benign tumors, and premalignant/malignant tumors. GDS fecal carriages were calculated overall and in each subgroup and compared. The data from 259 subjects were analyzed. GDS were identified in the feces of 12 subjects, with the following distribution:
S. lutetiensis
(
n
= 9),
S. pasteurianus
(
n
= 2), and
S. gallolyticus
(
n
= 1). This accounted for an overall GDS fecal carriage rate of 4.6 %. The GDS fecal carriage rate was 6 % in case of normal colonoscopy, 1.3 % in case of non-tumoral lesions, 3.2 % in case of benign tumors, and 11 % in case of premalignant/malignant tumors. These four percentages were not statistically different. The GDS fecal carriage rate was lower than expected, which did not confirm our working hypothesis. Most strains belonged to
S. bovis
biotype II, while
S. gallolyticus
was found only once. These findings suggest that different GDS play different roles in the etiopathogenesis of IE and colorectal cancer. |
| doi_str_mv | 10.1007/s10096-013-1863-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_00935825v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1426010114</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-32225c53a9641710f1f5579aaed1b40ec4c57b501ebb88dcfb10517db1a72a183</originalsourceid><addsrcrecordid>eNqNkt2K1TAUhYMozvHoA3gjBRFGmDr5aZp27oZBHeGAF-p12E13xwxt0knaoz7LvKwpPTP-gOBNAmt_a2cnWYQ8Z_QNo1SdxrTWZU6ZyFlVilw8IBtWCJkXQomHZENrUeS14uKIPInxmiZPpdRjcsSFlJUo-YbcfpoCjpM33pg5Zo3f23j6p4Y3s3VpN34Ye_yedWigzwyEYOEKT5Le-4BmWkVjnR_gJAPXZtYldrJ7zNC1PhVbO9l4lkHm8FsG4xjAxmTzXZLu2hvv3OLy7il51EEf8dlh35Iv795-vrjMdx_ff7g43-WmKOspF5xzaaSAuiyYYrRjnZSqBsCWNQVFUxipGkkZNk1VtaZrGJVMtQ0DxYFVYkter32_Qq_HYAcIP7QHqy_Pd3rR0isLWXG5Z4k9Xtkx-JsZ46QHGw32PTj0c9Tp-WsuqkKK_0B5SRllybIlL_9Cr_0cXLr0QglaSkqXOdlKmeBjDNjdD8uoXgKh10DoFAi9BEIvQ7w4dJ6bAdt7x10CEvDqAEBM_9oFcMbGX5wqFS3T_beEr1xMJXeF4bcR_3n6TyD3zmM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1423065008</pqid></control><display><type>article</type><title>Streptococcus bovis/Streptococcus equinus complex fecal carriage, colorectal carcinoma, and infective endocarditis: a new appraisal of a complex connection</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Chirouze, C. ; Patry, I. ; Duval, X. ; Baty, V. ; Tattevin, P. ; Aparicio, T. ; Pagenault, M. ; Carbonnel, F. ; Couetdic, G. ; Hoen, B.</creator><creatorcontrib>Chirouze, C. ; Patry, I. ; Duval, X. ; Baty, V. ; Tattevin, P. ; Aparicio, T. ; Pagenault, M. ; Carbonnel, F. ; Couetdic, G. ; Hoen, B.</creatorcontrib><description>The proportion of group D streptococcal infective endocarditis (IE) (predominantly due to
Streptococcus gallolyticus
) and the incidence of colorectal cancer are higher in France than in most European countries. We assumed that this could be explained by a high group D streptococci (GDS) fecal carriage rate. The aims of this study were to re-assess the GDS fecal carriage rate in France and its relationship with colorectal cancer. Consecutive adult subjects who were to undergo a complete colonoscopy were invited to participate. GDS were searched in subjects’ stools before their colonoscopy using biomolecular techniques. Colonoscopic findings were sorted into four subgroups: normal colonoscopy, non-tumoral lesions, benign tumors, and premalignant/malignant tumors. GDS fecal carriages were calculated overall and in each subgroup and compared. The data from 259 subjects were analyzed. GDS were identified in the feces of 12 subjects, with the following distribution:
S. lutetiensis
(
n
= 9),
S. pasteurianus
(
n
= 2), and
S. gallolyticus
(
n
= 1). This accounted for an overall GDS fecal carriage rate of 4.6 %. The GDS fecal carriage rate was 6 % in case of normal colonoscopy, 1.3 % in case of non-tumoral lesions, 3.2 % in case of benign tumors, and 11 % in case of premalignant/malignant tumors. These four percentages were not statistically different. The GDS fecal carriage rate was lower than expected, which did not confirm our working hypothesis. Most strains belonged to
S. bovis
biotype II, while
S. gallolyticus
was found only once. These findings suggest that different GDS play different roles in the etiopathogenesis of IE and colorectal cancer.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-013-1863-3</identifier><identifier>PMID: 23558362</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cardiology. Vascular system ; Carrier State ; Colonoscopy ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - microbiology ; Disease ; Endocardial and cardiac valvular diseases ; Endocarditis ; Endocarditis, Bacterial - epidemiology ; Endocarditis, Bacterial - microbiology ; Feces ; Feces - microbiology ; Female ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Heart ; Hospitals ; Human health and pathology ; Humans ; Hypotheses ; Infectious diseases ; Internal Medicine ; Lesions ; Life Sciences ; Male ; Medical Microbiology ; Medical sciences ; Middle Aged ; Prospective Studies ; RNA, Ribosomal, 16S - genetics ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Streptococcal Infections - epidemiology ; Streptococcal Infections - microbiology ; Streptococcus ; Streptococcus bovis ; Streptococcus bovis - isolation & purification ; Streptococcus equi - isolation & purification ; Streptococcus equinus ; Streptococcus gallolyticus ; Tumors ; Young Adult</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2013-09, Vol.32 (9), p.1171-1176</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>2014 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-32225c53a9641710f1f5579aaed1b40ec4c57b501ebb88dcfb10517db1a72a183</citedby><cites>FETCH-LOGICAL-c469t-32225c53a9641710f1f5579aaed1b40ec4c57b501ebb88dcfb10517db1a72a183</cites><orcidid>0000-0002-4779-5168 ; 0000-0002-6150-2376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-013-1863-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-013-1863-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27670609$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23558362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00935825$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Chirouze, C.</creatorcontrib><creatorcontrib>Patry, I.</creatorcontrib><creatorcontrib>Duval, X.</creatorcontrib><creatorcontrib>Baty, V.</creatorcontrib><creatorcontrib>Tattevin, P.</creatorcontrib><creatorcontrib>Aparicio, T.</creatorcontrib><creatorcontrib>Pagenault, M.</creatorcontrib><creatorcontrib>Carbonnel, F.</creatorcontrib><creatorcontrib>Couetdic, G.</creatorcontrib><creatorcontrib>Hoen, B.</creatorcontrib><title>Streptococcus bovis/Streptococcus equinus complex fecal carriage, colorectal carcinoma, and infective endocarditis: a new appraisal of a complex connection</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>The proportion of group D streptococcal infective endocarditis (IE) (predominantly due to
Streptococcus gallolyticus
) and the incidence of colorectal cancer are higher in France than in most European countries. We assumed that this could be explained by a high group D streptococci (GDS) fecal carriage rate. The aims of this study were to re-assess the GDS fecal carriage rate in France and its relationship with colorectal cancer. Consecutive adult subjects who were to undergo a complete colonoscopy were invited to participate. GDS were searched in subjects’ stools before their colonoscopy using biomolecular techniques. Colonoscopic findings were sorted into four subgroups: normal colonoscopy, non-tumoral lesions, benign tumors, and premalignant/malignant tumors. GDS fecal carriages were calculated overall and in each subgroup and compared. The data from 259 subjects were analyzed. GDS were identified in the feces of 12 subjects, with the following distribution:
S. lutetiensis
(
n
= 9),
S. pasteurianus
(
n
= 2), and
S. gallolyticus
(
n
= 1). This accounted for an overall GDS fecal carriage rate of 4.6 %. The GDS fecal carriage rate was 6 % in case of normal colonoscopy, 1.3 % in case of non-tumoral lesions, 3.2 % in case of benign tumors, and 11 % in case of premalignant/malignant tumors. These four percentages were not statistically different. The GDS fecal carriage rate was lower than expected, which did not confirm our working hypothesis. Most strains belonged to
S. bovis
biotype II, while
S. gallolyticus
was found only once. These findings suggest that different GDS play different roles in the etiopathogenesis of IE and colorectal cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiology. Vascular system</subject><subject>Carrier State</subject><subject>Colonoscopy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Colorectal Neoplasms - microbiology</subject><subject>Disease</subject><subject>Endocardial and cardiac valvular diseases</subject><subject>Endocarditis</subject><subject>Endocarditis, Bacterial - epidemiology</subject><subject>Endocarditis, Bacterial - microbiology</subject><subject>Feces</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Heart</subject><subject>Hospitals</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Lesions</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Streptococcal Infections - epidemiology</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcus</subject><subject>Streptococcus bovis</subject><subject>Streptococcus bovis - isolation & purification</subject><subject>Streptococcus equi - isolation & purification</subject><subject>Streptococcus equinus</subject><subject>Streptococcus gallolyticus</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkt2K1TAUhYMozvHoA3gjBRFGmDr5aZp27oZBHeGAF-p12E13xwxt0knaoz7LvKwpPTP-gOBNAmt_a2cnWYQ8Z_QNo1SdxrTWZU6ZyFlVilw8IBtWCJkXQomHZENrUeS14uKIPInxmiZPpdRjcsSFlJUo-YbcfpoCjpM33pg5Zo3f23j6p4Y3s3VpN34Ye_yedWigzwyEYOEKT5Le-4BmWkVjnR_gJAPXZtYldrJ7zNC1PhVbO9l4lkHm8FsG4xjAxmTzXZLu2hvv3OLy7il51EEf8dlh35Iv795-vrjMdx_ff7g43-WmKOspF5xzaaSAuiyYYrRjnZSqBsCWNQVFUxipGkkZNk1VtaZrGJVMtQ0DxYFVYkter32_Qq_HYAcIP7QHqy_Pd3rR0isLWXG5Z4k9Xtkx-JsZ46QHGw32PTj0c9Tp-WsuqkKK_0B5SRllybIlL_9Cr_0cXLr0QglaSkqXOdlKmeBjDNjdD8uoXgKh10DoFAi9BEIvQ7w4dJ6bAdt7x10CEvDqAEBM_9oFcMbGX5wqFS3T_beEr1xMJXeF4bcR_3n6TyD3zmM</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Chirouze, C.</creator><creator>Patry, I.</creator><creator>Duval, X.</creator><creator>Baty, V.</creator><creator>Tattevin, P.</creator><creator>Aparicio, T.</creator><creator>Pagenault, M.</creator><creator>Carbonnel, F.</creator><creator>Couetdic, G.</creator><creator>Hoen, B.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-4779-5168</orcidid><orcidid>https://orcid.org/0000-0002-6150-2376</orcidid></search><sort><creationdate>20130901</creationdate><title>Streptococcus bovis/Streptococcus equinus complex fecal carriage, colorectal carcinoma, and infective endocarditis: a new appraisal of a complex connection</title><author>Chirouze, C. ; Patry, I. ; Duval, X. ; Baty, V. ; Tattevin, P. ; Aparicio, T. ; Pagenault, M. ; Carbonnel, F. ; Couetdic, G. ; Hoen, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-32225c53a9641710f1f5579aaed1b40ec4c57b501ebb88dcfb10517db1a72a183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiology. Vascular system</topic><topic>Carrier State</topic><topic>Colonoscopy</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Colorectal Neoplasms - microbiology</topic><topic>Disease</topic><topic>Endocardial and cardiac valvular diseases</topic><topic>Endocarditis</topic><topic>Endocarditis, Bacterial - epidemiology</topic><topic>Endocarditis, Bacterial - microbiology</topic><topic>Feces</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Heart</topic><topic>Hospitals</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Infectious diseases</topic><topic>Internal Medicine</topic><topic>Lesions</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Streptococcal Infections - epidemiology</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcus</topic><topic>Streptococcus bovis</topic><topic>Streptococcus bovis - isolation & purification</topic><topic>Streptococcus equi - isolation & purification</topic><topic>Streptococcus equinus</topic><topic>Streptococcus gallolyticus</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chirouze, C.</creatorcontrib><creatorcontrib>Patry, I.</creatorcontrib><creatorcontrib>Duval, X.</creatorcontrib><creatorcontrib>Baty, V.</creatorcontrib><creatorcontrib>Tattevin, P.</creatorcontrib><creatorcontrib>Aparicio, T.</creatorcontrib><creatorcontrib>Pagenault, M.</creatorcontrib><creatorcontrib>Carbonnel, F.</creatorcontrib><creatorcontrib>Couetdic, G.</creatorcontrib><creatorcontrib>Hoen, B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chirouze, C.</au><au>Patry, I.</au><au>Duval, X.</au><au>Baty, V.</au><au>Tattevin, P.</au><au>Aparicio, T.</au><au>Pagenault, M.</au><au>Carbonnel, F.</au><au>Couetdic, G.</au><au>Hoen, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Streptococcus bovis/Streptococcus equinus complex fecal carriage, colorectal carcinoma, and infective endocarditis: a new appraisal of a complex connection</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>32</volume><issue>9</issue><spage>1171</spage><epage>1176</epage><pages>1171-1176</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>The proportion of group D streptococcal infective endocarditis (IE) (predominantly due to
Streptococcus gallolyticus
) and the incidence of colorectal cancer are higher in France than in most European countries. We assumed that this could be explained by a high group D streptococci (GDS) fecal carriage rate. The aims of this study were to re-assess the GDS fecal carriage rate in France and its relationship with colorectal cancer. Consecutive adult subjects who were to undergo a complete colonoscopy were invited to participate. GDS were searched in subjects’ stools before their colonoscopy using biomolecular techniques. Colonoscopic findings were sorted into four subgroups: normal colonoscopy, non-tumoral lesions, benign tumors, and premalignant/malignant tumors. GDS fecal carriages were calculated overall and in each subgroup and compared. The data from 259 subjects were analyzed. GDS were identified in the feces of 12 subjects, with the following distribution:
S. lutetiensis
(
n
= 9),
S. pasteurianus
(
n
= 2), and
S. gallolyticus
(
n
= 1). This accounted for an overall GDS fecal carriage rate of 4.6 %. The GDS fecal carriage rate was 6 % in case of normal colonoscopy, 1.3 % in case of non-tumoral lesions, 3.2 % in case of benign tumors, and 11 % in case of premalignant/malignant tumors. These four percentages were not statistically different. The GDS fecal carriage rate was lower than expected, which did not confirm our working hypothesis. Most strains belonged to
S. bovis
biotype II, while
S. gallolyticus
was found only once. These findings suggest that different GDS play different roles in the etiopathogenesis of IE and colorectal cancer.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23558362</pmid><doi>10.1007/s10096-013-1863-3</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4779-5168</orcidid><orcidid>https://orcid.org/0000-0002-6150-2376</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2013-09, Vol.32 (9), p.1171-1176 |
| issn | 0934-9723 1435-4373 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_00935825v1 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomedical and Life Sciences Biomedicine Cardiology. Vascular system Carrier State Colonoscopy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - epidemiology Colorectal Neoplasms - microbiology Disease Endocardial and cardiac valvular diseases Endocarditis Endocarditis, Bacterial - epidemiology Endocarditis, Bacterial - microbiology Feces Feces - microbiology Female Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Heart Hospitals Human health and pathology Humans Hypotheses Infectious diseases Internal Medicine Lesions Life Sciences Male Medical Microbiology Medical sciences Middle Aged Prospective Studies RNA, Ribosomal, 16S - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Streptococcal Infections - epidemiology Streptococcal Infections - microbiology Streptococcus Streptococcus bovis Streptococcus bovis - isolation & purification Streptococcus equi - isolation & purification Streptococcus equinus Streptococcus gallolyticus Tumors Young Adult |
| title | Streptococcus bovis/Streptococcus equinus complex fecal carriage, colorectal carcinoma, and infective endocarditis: a new appraisal of a complex connection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T10%3A15%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Streptococcus%20bovis/Streptococcus%20equinus%20complex%20fecal%20carriage,%20colorectal%20carcinoma,%20and%20infective%20endocarditis:%20a%20new%20appraisal%20of%20a%20complex%20connection&rft.jtitle=European%20journal%20of%20clinical%20microbiology%20&%20infectious%20diseases&rft.au=Chirouze,%20C.&rft.date=2013-09-01&rft.volume=32&rft.issue=9&rft.spage=1171&rft.epage=1176&rft.pages=1171-1176&rft.issn=0934-9723&rft.eissn=1435-4373&rft_id=info:doi/10.1007/s10096-013-1863-3&rft_dat=%3Cproquest_hal_p%3E1426010114%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1423065008&rft_id=info:pmid/23558362&rfr_iscdi=true |