Analysis of 18F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin’s lymphoma: a reflection of disease infiltration or just inflammation?
Purpose 18 F-FDG PET has been successfully evaluated in the management of Hodgkin’s lymphoma (HL) and the most recent international guidelines recommended 18 F-FDG PET for initial staging and final therapeutic assessment. However, 18 F-FDG PET diffuse bone marrow uptake (BMU) and splenic uptake (SU)...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2009-11, Vol.36 (11), p.1813-1821 |
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| container_title | European journal of nuclear medicine and molecular imaging |
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| creator | Salaun, Pierre Y. Gastinne, Thomas Bodet-Milin, Caroline Campion, Loïc Cambefort, Pierre Moreau, Anne Le Gouill, Steven Berthou, Christian Moreau, Philippe Kraeber-Bodéré, Françoise |
| description | Purpose
18
F-FDG PET has been successfully evaluated in the management of Hodgkin’s lymphoma (HL) and the most recent international guidelines recommended
18
F-FDG PET for initial staging and final therapeutic assessment. However,
18
F-FDG PET diffuse bone marrow uptake (BMU) and splenic uptake (SU) are frequently observed at the initial imaging and remain difficult to analyse. The aim of this retrospective study was to evaluate the significance of
18
F-FDG diffuse BMU and SU in initial staging of HL.
Methods
A total of 106 patients (median age: 31 years, range: 9–81, 51 female, 55 male) underwent
18
F-FDG PET/CT for initial staging of HL. BMU level was assessed visually according to liver uptake (1 = below liver uptake, 2 = corresponding to liver uptake, 3 = above liver uptake) and semi-quantitatively using the maximum standardized uptake value (SUV
max
) measured in the sacral area. SU was assessed visually according to liver uptake (1 = below liver uptake, 2 = corresponding to liver uptake, 3 = above liver uptake). These data were compared with the patient’s characteristics including sex, age, Ann Arbor staging, bulky disease (tumour burden > 10 cm), presence of B symptoms, bone foci on PET (
n
= 106), bone marrow involvement (BMI) on biopsy (
n
= 75), leukocyte count (
n
= 74), lactic dehydrogenase (LDH) (
n
= 87), C-reactive protein (CRP) (
n
= 83) and fibrinogen (
n
= 60). Univariate and multivariate analyses were performed.
Results
Multivariate analysis found an independent correlation between BMU visual grading and CRP level (
p
= 0.007). For semi-quantitative BMU evaluation, multivariate analysis found an independent correlation between sacral SUVs and CRP level (
p
= 0.032) and Ann Arbor stage (
p
= 0.005). No BMI was found in patients who presented with SUV
max
below 3.4. For splenic evaluation, multivariate analysis found an independent correlation between SU and splenic foci (
p
= 0.034). No statistical link was found between SU and inflammatory markers.
Conclusion
Our study demonstrates that diffuse BMU at initial staging of HL could be due to bone marrow involvement but more likely to bone marrow inflammatory change and that diffuse SU in contrast is probably more associated with disease involvement than with inflammatory change. |
| doi_str_mv | 10.1007/s00259-009-1183-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_00927531v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733519090</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3150-ac560e952a5c38eed864098b54f182881c4b2c6b389791dbc8d9eed22ccd814a3</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhiMEoqXwAFyQxQVxCNhOnNhcqlXpdpFWgkM5W47jbL117OBJQHvjNbjzZDwJMVlaCYmTrd_f_OOZP8ueE_yGYFy_BYwpEznGIieEFzl-kJ2Sioi8xlw8vLvX-CR7ArDHmHDKxePshIhSCErEafZz5ZU7gAUUOkT4Ol-_v0KfLq9Ra7tuAoOa4A3qVYzhG5qGUd0apHyLYHDGW_1Xsh7BqHbW75LPJrS7W-t_ff8ByB364Sb06h1SKJrOGT3a4BPVWjAKUm1n3RjVoke0n2BMolN9_0c8f5o96pQD8-x4nmWf15fXF5t8-_Hqw8Vqm-uCMJwrzSpsBKOK6YIb0_KqxII3rOzS4JzosqG6agouakHaRvNWzBSlWreclKo4y14vvjfKySHaeeyDDMrKzWorkzZvmtasIF_JzL5a2CGGL5OBUfYWtHFOeRMmkHVRMCKwwDP58h9yH6Y4rx0kJWXFSs6SHVkgHQPAvKi7_gTLFLZcwk5fkClsmYxfHI2npjftfcUx3RmgCwDzk9-ZeN_5_66_Aaq3tbE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214654851</pqid></control><display><type>article</type><title>Analysis of 18F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin’s lymphoma: a reflection of disease infiltration or just inflammation?</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Salaun, Pierre Y. ; Gastinne, Thomas ; Bodet-Milin, Caroline ; Campion, Loïc ; Cambefort, Pierre ; Moreau, Anne ; Le Gouill, Steven ; Berthou, Christian ; Moreau, Philippe ; Kraeber-Bodéré, Françoise</creator><creatorcontrib>Salaun, Pierre Y. ; Gastinne, Thomas ; Bodet-Milin, Caroline ; Campion, Loïc ; Cambefort, Pierre ; Moreau, Anne ; Le Gouill, Steven ; Berthou, Christian ; Moreau, Philippe ; Kraeber-Bodéré, Françoise</creatorcontrib><description>Purpose
18
F-FDG PET has been successfully evaluated in the management of Hodgkin’s lymphoma (HL) and the most recent international guidelines recommended
18
F-FDG PET for initial staging and final therapeutic assessment. However,
18
F-FDG PET diffuse bone marrow uptake (BMU) and splenic uptake (SU) are frequently observed at the initial imaging and remain difficult to analyse. The aim of this retrospective study was to evaluate the significance of
18
F-FDG diffuse BMU and SU in initial staging of HL.
Methods
A total of 106 patients (median age: 31 years, range: 9–81, 51 female, 55 male) underwent
18
F-FDG PET/CT for initial staging of HL. BMU level was assessed visually according to liver uptake (1 = below liver uptake, 2 = corresponding to liver uptake, 3 = above liver uptake) and semi-quantitatively using the maximum standardized uptake value (SUV
max
) measured in the sacral area. SU was assessed visually according to liver uptake (1 = below liver uptake, 2 = corresponding to liver uptake, 3 = above liver uptake). These data were compared with the patient’s characteristics including sex, age, Ann Arbor staging, bulky disease (tumour burden > 10 cm), presence of B symptoms, bone foci on PET (
n
= 106), bone marrow involvement (BMI) on biopsy (
n
= 75), leukocyte count (
n
= 74), lactic dehydrogenase (LDH) (
n
= 87), C-reactive protein (CRP) (
n
= 83) and fibrinogen (
n
= 60). Univariate and multivariate analyses were performed.
Results
Multivariate analysis found an independent correlation between BMU visual grading and CRP level (
p
= 0.007). For semi-quantitative BMU evaluation, multivariate analysis found an independent correlation between sacral SUVs and CRP level (
p
= 0.032) and Ann Arbor stage (
p
= 0.005). No BMI was found in patients who presented with SUV
max
below 3.4. For splenic evaluation, multivariate analysis found an independent correlation between SU and splenic foci (
p
= 0.034). No statistical link was found between SU and inflammatory markers.
Conclusion
Our study demonstrates that diffuse BMU at initial staging of HL could be due to bone marrow involvement but more likely to bone marrow inflammatory change and that diffuse SU in contrast is probably more associated with disease involvement than with inflammatory change.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-009-1183-0</identifier><identifier>PMID: 19499219</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bone Marrow ; Bone Marrow - metabolism ; Cardiology ; Child ; Diffusion ; Female ; Fluorodeoxyglucose F18 ; Fluorodeoxyglucose F18 - metabolism ; Hodgkin Disease ; Hodgkin Disease - diagnostic imaging ; Hodgkin Disease - metabolism ; Hodgkin Disease - pathology ; Humans ; Imaging ; Inflammation ; Inflammation - complications ; Inflammation - metabolism ; Life Sciences ; Lymphoma ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Staging ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; Positron-Emission Tomography ; Radiology ; Retrospective Studies ; Spleen ; Spleen - metabolism ; Tomography ; Tomography, X-Ray Computed ; Young Adult</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2009-11, Vol.36 (11), p.1813-1821</ispartof><rights>Springer-Verlag 2009</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3150-ac560e952a5c38eed864098b54f182881c4b2c6b389791dbc8d9eed22ccd814a3</citedby><cites>FETCH-LOGICAL-c3150-ac560e952a5c38eed864098b54f182881c4b2c6b389791dbc8d9eed22ccd814a3</cites><orcidid>0000-0001-9840-2128 ; 0000-0003-4903-0908 ; 0000-0002-8219-3592 ; 0000-0003-1780-8746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-009-1183-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-009-1183-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,315,781,785,886,27928,27929,41492,42561,51323</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19499219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-brest.fr/hal-00927531$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Salaun, Pierre Y.</creatorcontrib><creatorcontrib>Gastinne, Thomas</creatorcontrib><creatorcontrib>Bodet-Milin, Caroline</creatorcontrib><creatorcontrib>Campion, Loïc</creatorcontrib><creatorcontrib>Cambefort, Pierre</creatorcontrib><creatorcontrib>Moreau, Anne</creatorcontrib><creatorcontrib>Le Gouill, Steven</creatorcontrib><creatorcontrib>Berthou, Christian</creatorcontrib><creatorcontrib>Moreau, Philippe</creatorcontrib><creatorcontrib>Kraeber-Bodéré, Françoise</creatorcontrib><title>Analysis of 18F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin’s lymphoma: a reflection of disease infiltration or just inflammation?</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
18
F-FDG PET has been successfully evaluated in the management of Hodgkin’s lymphoma (HL) and the most recent international guidelines recommended
18
F-FDG PET for initial staging and final therapeutic assessment. However,
18
F-FDG PET diffuse bone marrow uptake (BMU) and splenic uptake (SU) are frequently observed at the initial imaging and remain difficult to analyse. The aim of this retrospective study was to evaluate the significance of
18
F-FDG diffuse BMU and SU in initial staging of HL.
Methods
A total of 106 patients (median age: 31 years, range: 9–81, 51 female, 55 male) underwent
18
F-FDG PET/CT for initial staging of HL. BMU level was assessed visually according to liver uptake (1 = below liver uptake, 2 = corresponding to liver uptake, 3 = above liver uptake) and semi-quantitatively using the maximum standardized uptake value (SUV
max
) measured in the sacral area. SU was assessed visually according to liver uptake (1 = below liver uptake, 2 = corresponding to liver uptake, 3 = above liver uptake). These data were compared with the patient’s characteristics including sex, age, Ann Arbor staging, bulky disease (tumour burden > 10 cm), presence of B symptoms, bone foci on PET (
n
= 106), bone marrow involvement (BMI) on biopsy (
n
= 75), leukocyte count (
n
= 74), lactic dehydrogenase (LDH) (
n
= 87), C-reactive protein (CRP) (
n
= 83) and fibrinogen (
n
= 60). Univariate and multivariate analyses were performed.
Results
Multivariate analysis found an independent correlation between BMU visual grading and CRP level (
p
= 0.007). For semi-quantitative BMU evaluation, multivariate analysis found an independent correlation between sacral SUVs and CRP level (
p
= 0.032) and Ann Arbor stage (
p
= 0.005). No BMI was found in patients who presented with SUV
max
below 3.4. For splenic evaluation, multivariate analysis found an independent correlation between SU and splenic foci (
p
= 0.034). No statistical link was found between SU and inflammatory markers.
Conclusion
Our study demonstrates that diffuse BMU at initial staging of HL could be due to bone marrow involvement but more likely to bone marrow inflammatory change and that diffuse SU in contrast is probably more associated with disease involvement than with inflammatory change.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Marrow</subject><subject>Bone Marrow - metabolism</subject><subject>Cardiology</subject><subject>Child</subject><subject>Diffusion</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Fluorodeoxyglucose F18 - metabolism</subject><subject>Hodgkin Disease</subject><subject>Hodgkin Disease - diagnostic imaging</subject><subject>Hodgkin Disease - metabolism</subject><subject>Hodgkin Disease - pathology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Inflammation</subject><subject>Inflammation - complications</subject><subject>Inflammation - metabolism</subject><subject>Life Sciences</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Positron-Emission Tomography</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Spleen</subject><subject>Spleen - metabolism</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><subject>Young Adult</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kcFu1DAQhiMEoqXwAFyQxQVxCNhOnNhcqlXpdpFWgkM5W47jbL117OBJQHvjNbjzZDwJMVlaCYmTrd_f_OOZP8ueE_yGYFy_BYwpEznGIieEFzl-kJ2Sioi8xlw8vLvX-CR7ArDHmHDKxePshIhSCErEafZz5ZU7gAUUOkT4Ol-_v0KfLq9Ra7tuAoOa4A3qVYzhG5qGUd0apHyLYHDGW_1Xsh7BqHbW75LPJrS7W-t_ff8ByB364Sb06h1SKJrOGT3a4BPVWjAKUm1n3RjVoke0n2BMolN9_0c8f5o96pQD8-x4nmWf15fXF5t8-_Hqw8Vqm-uCMJwrzSpsBKOK6YIb0_KqxII3rOzS4JzosqG6agouakHaRvNWzBSlWreclKo4y14vvjfKySHaeeyDDMrKzWorkzZvmtasIF_JzL5a2CGGL5OBUfYWtHFOeRMmkHVRMCKwwDP58h9yH6Y4rx0kJWXFSs6SHVkgHQPAvKi7_gTLFLZcwk5fkClsmYxfHI2npjftfcUx3RmgCwDzk9-ZeN_5_66_Aaq3tbE</recordid><startdate>200911</startdate><enddate>200911</enddate><creator>Salaun, Pierre Y.</creator><creator>Gastinne, Thomas</creator><creator>Bodet-Milin, Caroline</creator><creator>Campion, Loïc</creator><creator>Cambefort, Pierre</creator><creator>Moreau, Anne</creator><creator>Le Gouill, Steven</creator><creator>Berthou, Christian</creator><creator>Moreau, Philippe</creator><creator>Kraeber-Bodéré, Françoise</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><general>Springer Verlag (Germany) [1976-....]</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-9840-2128</orcidid><orcidid>https://orcid.org/0000-0003-4903-0908</orcidid><orcidid>https://orcid.org/0000-0002-8219-3592</orcidid><orcidid>https://orcid.org/0000-0003-1780-8746</orcidid></search><sort><creationdate>200911</creationdate><title>Analysis of 18F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin’s lymphoma: a reflection of disease infiltration or just inflammation?</title><author>Salaun, Pierre Y. ; Gastinne, Thomas ; Bodet-Milin, Caroline ; Campion, Loïc ; Cambefort, Pierre ; Moreau, Anne ; Le Gouill, Steven ; Berthou, Christian ; Moreau, Philippe ; Kraeber-Bodéré, Françoise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3150-ac560e952a5c38eed864098b54f182881c4b2c6b389791dbc8d9eed22ccd814a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Marrow</topic><topic>Bone Marrow - metabolism</topic><topic>Cardiology</topic><topic>Child</topic><topic>Diffusion</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Fluorodeoxyglucose F18 - metabolism</topic><topic>Hodgkin Disease</topic><topic>Hodgkin Disease - diagnostic imaging</topic><topic>Hodgkin Disease - metabolism</topic><topic>Hodgkin Disease - pathology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Inflammation</topic><topic>Inflammation - complications</topic><topic>Inflammation - metabolism</topic><topic>Life Sciences</topic><topic>Lymphoma</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Positron-Emission Tomography</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Spleen</topic><topic>Spleen - metabolism</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salaun, Pierre Y.</creatorcontrib><creatorcontrib>Gastinne, Thomas</creatorcontrib><creatorcontrib>Bodet-Milin, Caroline</creatorcontrib><creatorcontrib>Campion, Loïc</creatorcontrib><creatorcontrib>Cambefort, Pierre</creatorcontrib><creatorcontrib>Moreau, Anne</creatorcontrib><creatorcontrib>Le Gouill, Steven</creatorcontrib><creatorcontrib>Berthou, Christian</creatorcontrib><creatorcontrib>Moreau, Philippe</creatorcontrib><creatorcontrib>Kraeber-Bodéré, Françoise</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salaun, Pierre Y.</au><au>Gastinne, Thomas</au><au>Bodet-Milin, Caroline</au><au>Campion, Loïc</au><au>Cambefort, Pierre</au><au>Moreau, Anne</au><au>Le Gouill, Steven</au><au>Berthou, Christian</au><au>Moreau, Philippe</au><au>Kraeber-Bodéré, Françoise</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of 18F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin’s lymphoma: a reflection of disease infiltration or just inflammation?</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2009-11</date><risdate>2009</risdate><volume>36</volume><issue>11</issue><spage>1813</spage><epage>1821</epage><pages>1813-1821</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
18
F-FDG PET has been successfully evaluated in the management of Hodgkin’s lymphoma (HL) and the most recent international guidelines recommended
18
F-FDG PET for initial staging and final therapeutic assessment. However,
18
F-FDG PET diffuse bone marrow uptake (BMU) and splenic uptake (SU) are frequently observed at the initial imaging and remain difficult to analyse. The aim of this retrospective study was to evaluate the significance of
18
F-FDG diffuse BMU and SU in initial staging of HL.
Methods
A total of 106 patients (median age: 31 years, range: 9–81, 51 female, 55 male) underwent
18
F-FDG PET/CT for initial staging of HL. BMU level was assessed visually according to liver uptake (1 = below liver uptake, 2 = corresponding to liver uptake, 3 = above liver uptake) and semi-quantitatively using the maximum standardized uptake value (SUV
max
) measured in the sacral area. SU was assessed visually according to liver uptake (1 = below liver uptake, 2 = corresponding to liver uptake, 3 = above liver uptake). These data were compared with the patient’s characteristics including sex, age, Ann Arbor staging, bulky disease (tumour burden > 10 cm), presence of B symptoms, bone foci on PET (
n
= 106), bone marrow involvement (BMI) on biopsy (
n
= 75), leukocyte count (
n
= 74), lactic dehydrogenase (LDH) (
n
= 87), C-reactive protein (CRP) (
n
= 83) and fibrinogen (
n
= 60). Univariate and multivariate analyses were performed.
Results
Multivariate analysis found an independent correlation between BMU visual grading and CRP level (
p
= 0.007). For semi-quantitative BMU evaluation, multivariate analysis found an independent correlation between sacral SUVs and CRP level (
p
= 0.032) and Ann Arbor stage (
p
= 0.005). No BMI was found in patients who presented with SUV
max
below 3.4. For splenic evaluation, multivariate analysis found an independent correlation between SU and splenic foci (
p
= 0.034). No statistical link was found between SU and inflammatory markers.
Conclusion
Our study demonstrates that diffuse BMU at initial staging of HL could be due to bone marrow involvement but more likely to bone marrow inflammatory change and that diffuse SU in contrast is probably more associated with disease involvement than with inflammatory change.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19499219</pmid><doi>10.1007/s00259-009-1183-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9840-2128</orcidid><orcidid>https://orcid.org/0000-0003-4903-0908</orcidid><orcidid>https://orcid.org/0000-0002-8219-3592</orcidid><orcidid>https://orcid.org/0000-0003-1780-8746</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2009-11, Vol.36 (11), p.1813-1821 |
| issn | 1619-7070 1619-7089 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_00927531v1 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Bone Marrow Bone Marrow - metabolism Cardiology Child Diffusion Female Fluorodeoxyglucose F18 Fluorodeoxyglucose F18 - metabolism Hodgkin Disease Hodgkin Disease - diagnostic imaging Hodgkin Disease - metabolism Hodgkin Disease - pathology Humans Imaging Inflammation Inflammation - complications Inflammation - metabolism Life Sciences Lymphoma Male Medicine Medicine & Public Health Middle Aged Neoplasm Staging Nuclear Medicine Oncology Original Article Orthopedics Positron-Emission Tomography Radiology Retrospective Studies Spleen Spleen - metabolism Tomography Tomography, X-Ray Computed Young Adult |
| title | Analysis of 18F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin’s lymphoma: a reflection of disease infiltration or just inflammation? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T01%3A21%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%2018F-FDG%20PET%20diffuse%20bone%20marrow%20uptake%20and%20splenic%20uptake%20in%20staging%20of%20Hodgkin%E2%80%99s%20lymphoma:%20a%20reflection%20of%20disease%20infiltration%20or%20just%20inflammation?&rft.jtitle=European%20journal%20of%20nuclear%20medicine%20and%20molecular%20imaging&rft.au=Salaun,%20Pierre%20Y.&rft.date=2009-11&rft.volume=36&rft.issue=11&rft.spage=1813&rft.epage=1821&rft.pages=1813-1821&rft.issn=1619-7070&rft.eissn=1619-7089&rft_id=info:doi/10.1007/s00259-009-1183-0&rft_dat=%3Cproquest_hal_p%3E733519090%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=214654851&rft_id=info:pmid/19499219&rfr_iscdi=true |