N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines

Nine new 17-(piperazin-1-yl)pyridin-5-yl)steroids as abiraterone analogues were synthesized. Compounds 5d and 5g showed selective activities against 17α-hydroxylase/C17,20-lyase (CYP17A1) and aromatase (CYP19), respectively. IC50 values of 5d were 5.09 and >50 μm, whereas these values for 5g wer...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical biology & drug design 2013, Vol.82 (5), p.620-629
Hauptverfasser:	Brossard, Dominique, Zhang, Ying, Haider, Shozeb, Sgobba, Miriam, Khalid, Mohamed, Legay, Rémi, Duterque-Coquillaud, Martine, Galera, Philippe, Rault, Sylvain, Dallemagne, Patrick, Moslemi, Safa, El Kihel, Laïla
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Medicinal Chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!