Self-assembling peptide-enriched electrospun polycaprolactone scaffolds promote the h -osteoblast adhesion and modulate differentiation-associated gene expression

Abstract Electrospun polycaprolactone (PCL) is able to support the adhesion and growth of h -osteoblasts and to delay their degradation rate to a greater extent with respect to other polyesters. The drawbacks linked to its employment in regenerative medicine arise from its hydrophobic nature and the...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2012-11, Vol.51 (5), p.851-859
Hauptverfasser:	Danesin, Roberta, Brun, Paola, Roso, Martina, Delaunay, Florian, Samouillan, Valérie, Brunelli, Katya, Iucci, Giovanna, Ghezzo, Francesca, Modesti, Michele, Castagliuolo, Ignazio, Dettin, Monica
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Biological and medical sciences Bone sialoprotein Calorimetry, Differential Scanning Cell adhesion Cell Adhesion - physiology Cell Differentiation - physiology Differentiation Electrospinning Engineering Sciences Extracellular matrix Fibers Fundamental and applied biological sciences. Psychology Gene expression h-osteoblasts Human health and pathology Hybrids Hydrophobicity Life Sciences Micro and nanotechnologies Microelectronics Microscopy, Electron, Scanning Oligopeptides - chemistry Orthopedics Osteoblasts - cytology Osteopontin Peptides - chemical synthesis Peptides - chemistry Polycaprolactone polyesters Polyesters - chemistry Regeneration RGD scaffolds Self-assembling peptides Spectroscopy, Fourier Transform Infrared Tissue Engineering Tissue Scaffolds - chemistry Vertebrates: anatomy and physiology, studies on body, several organs or systems
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